Summary
After obtaining his degree in Biochemistry and Applied Clinical Biochemistry from UMIST in 2001, Andrew completed a PhD in Molecular Parasitology from the University of Manchester, studying the folate biosynthetic pathway of the malaria parasite Plasmodium falciparum. In 2006 he joined the Sinden lab at Imperial College, London, to study the sexual stages of Plasmodium, with an emphasis on developing transmission-blocking interventions (TBIs) to target the parasite within the mosquito host, inhibiting or preventing the onward transmission of malaria. He is currently a Principal Investigator in the DoLS, and his main interests focus on the identification of novel anti-malarial transmission blocking vaccine targets, vaccine delivery, the development of assays to examine TBI efficacy, and assessing the practical impact of introducing TBIs on populations of mosquitoes and vertebrate in both the laboratory and the field.
Publications
Journals
Sirignano C, Hammami S, El Mokni R, et al., 2021, Polyoxygenated germacranes from Daucus carota and their antimalarial transmission blocking activity, Phytochemistry: the International Journal of Plant Chemistry, Plant Biochemistry and Molecular Biology, Vol:183, ISSN:0031-9422
Miguel-Blanco C, Murithi JM, Benavente ED, et al., 2021, The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957, Scientific Reports, Vol:11, ISSN:2045-2322
Haltalli MLR, Watcham S, Wilson NK, et al., 2020, Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection, Nature Cell Biology, Vol:22, ISSN:1465-7392, Pages:1399-1410
Ukegbu CV, Giorgalli M, Tapanelli S, et al., 2020, PIMMS43 is required for malaria parasite immune evasion and sporogonic development in the mosquito vector, Proceedings of the National Academy of Sciences of Usa, Vol:117, ISSN:0027-8424, Pages:7363-7373
Muthui MK, Kamau A, Bousema T, et al., 2020, Corrigendum: immune responses to gametocyte antigens in a malaria endemic population-The African falciparum context: a systematic review and meta-analysis (vol 10, 2480, 2019), Frontiers in Immunology, Vol:11, ISSN:1664-3224, Pages:1-4