Publications
1189 results found
Greco KV, Francis L, Huang H, et al., 2018, Is quercetin an alternative natural crosslinking agent to genipin for long-term dermal scaffolds implantation?, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol: 12, Pages: E1716-E1724, ISSN: 1932-6254
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- Citations: 13
Gritsch L, Lovell C, Goldmann WH, et al., 2018, Do bioresorbable polyesters have antimicrobial properties?, Journal of Materials Science: Materials in Medicine, Vol: 29, ISSN: 0957-4530
Biodegradable and bioresorbable polyesters (BBPEs) are a widespread class of aliphatic polymers with a plethora of applications in the medical field. Some reports speculate that these polymers have intrinsic antibacterial activity as a consequence of their acidic degradation by-products. The release of organic acids as a result of the hydrolytic degradation of BBPEs in vivo and the resulting pH drop could be an effective inhibitor of the growth of pathogens in the local environment adjacent to BBPE-based devices. However, there is no clear and conclusive evidence in the literature concerning the antibacterial activity of BBPE to support or refute this hypothesis. In this communication we address this point through an assessment of the antibacterial properties of six well-established commercially available BBPEs. Agar diffusion assays and optical density measurements at 600 nm were performed on all the polymer samples to characterize the growth of bacteria and any potential inhibition over an incubation period of 24 h. The results indicated that BBPEs do not possess an intrinsic and immediate antibacterial activity, which is consistent with the clear mismatch between the time-scales for bacterial growth and the rate of degradation of the polyesters.
Boccaccini AR, Willoughby A, 2017, The 35th anniversary of <i>Materials Letters</i>, MATERIALS LETTERS, Vol: 208, Pages: 1-2, ISSN: 0167-577X
Molin S, Sabato AG, Bindi M, et al., 2017, Microstructural and electrical characterization of Mn-Co spinel protective coatings for solid oxide cell interconnects, JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, Vol: 37, Pages: 4781-4791, ISSN: 0955-2219
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- Citations: 53
Singh R, Wieser A, Reakasame S, et al., 2017, Cell specificity of magnetic cell seeding approach to hydrogel colonization, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol: 105, Pages: 2948-2956, ISSN: 1549-3296
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- Citations: 8
Ege D, Duru I, Kamali AR, et al., 2017, Nitride, Zirconia, Alumina, and Carbide Coatings on Ti6Al4V Femoral Heads: Effect of Deposition Techniques on Mechanical and Tribological Properties, ADVANCED ENGINEERING MATERIALS, Vol: 19, ISSN: 1438-1656
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- Citations: 10
Zheng K, Boccaccini AR, 2017, Sol-gel processing of bioactive glass nanoparticles: A review, ADVANCES IN COLLOID AND INTERFACE SCIENCE, Vol: 249, Pages: 363-373, ISSN: 0001-8686
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- Citations: 204
Hochleitner G, Kessler M, Schmitz M, et al., 2017, Melt electrospinning writing of defined scaffolds using polylactide-poly (ethylene glycol) blends with 45S5 bioactive glass particles, MATERIALS LETTERS, Vol: 205, Pages: 257-260, ISSN: 0167-577X
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- Citations: 33
Wagener V, Boccaccini AR, Virtanen S, 2017, Protein-adsorption and Ca-phosphate formation on chitosan-bioactive glass composite coatings, APPLIED SURFACE SCIENCE, Vol: 416, Pages: 454-460, ISSN: 0169-4332
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- Citations: 23
Rehman MAU, Bastan FE, Haider B, et al., 2017, Electrophoretic deposition of PEEK/bioactive glass composite coatings for orthopedic implants: A design of experiments (DoE) study, MATERIALS & DESIGN, Vol: 130, Pages: 223-230, ISSN: 0264-1275
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- Citations: 61
Araujo M, Viveiros R, Philippart A, et al., 2017, Bioactivity, mechanical properties and drug delivery ability of bioactive glass-ceramic scaffolds coated with a natural-derived polymer, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Vol: 77, Pages: 342-351, ISSN: 0928-4931
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- Citations: 25
Ramos-Rivera L, Distaso M, Peukert W, et al., 2017, Electrophoretic deposition of anisotropic α-Fe<sub>2</sub>O<sub>3</sub>/PVP/chitosan nanocomposites for biomedical applications, MATERIALS LETTERS, Vol: 200, Pages: 83-86, ISSN: 0167-577X
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- Citations: 7
Karbowniczek J, Cordero-Arias L, Virtanen S, et al., 2017, Electrophoretic deposition of organic/inorganic composite coatings containing ZnO nanoparticles exhibiting antibacterial properties, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Vol: 77, Pages: 780-789, ISSN: 0928-4931
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- Citations: 46
Taveri G, Tousek J, Bernardo E, et al., 2017, Proving the role of boron in the structure of fly-ash/borosilicate glass based geopolymers, MATERIALS LETTERS, Vol: 200, Pages: 105-108, ISSN: 0167-577X
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- Citations: 21
Meincke T, Pacheco VM, Hoffmann D, et al., 2017, Engineering the surface functionality of 45S5 bioactive glass-based scaffolds by the heterogeneous nucleation and growth of silver particles, JOURNAL OF MATERIALS SCIENCE, Vol: 52, Pages: 9082-9090, ISSN: 0022-2461
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- Citations: 8
Boccaccini AR, Fenn M, Jones JR, et al., 2017, Guest editors' preface, JOURNAL OF MATERIALS SCIENCE, Vol: 52, Pages: 8691-8694, ISSN: 0022-2461
Balasubramanian P, Hupa L, Jokic B, et al., 2017, Angiogenic potential of boron-containing bioactive glasses: in vitro study, JOURNAL OF MATERIALS SCIENCE, Vol: 52, Pages: 8785-8792, ISSN: 0022-2461
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- Citations: 61
Rivadeneira J, Laura Di Virgilio A, Carina Audisio M, et al., 2017, 45S5 Bioglass® concentrations modulate the release of vancomycin hydrochloride from gelatin-starch films: evaluation of antibacterial and cytotoxic effects, JOURNAL OF MATERIALS SCIENCE, Vol: 52, Pages: 9091-9102, ISSN: 0022-2461
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- Citations: 11
Tansaz S, Liverani L, Vester L, et al., 2017, Soy protein meets bioactive glass: Electrospun composite fibers for tissue engineering applications, MATERIALS LETTERS, Vol: 199, Pages: 143-146, ISSN: 0167-577X
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- Citations: 22
Qazi TH, Hafeez S, Schmidt J, et al., 2017, Comparison of the effects of 45S5 and 1393 bioactive glass microparticles on hMSC behavior, Journal of Biomedical Materials Research Part A, Vol: 105, Pages: 2772-2782, ISSN: 1549-3296
Bioactive glasses (BAGs) are highly interesting materials for bone regeneration applications in orthopedic and dental defects. It is quite well known that ionic release from BAGs influences cell behavior and function. Mindful of the clinical scenario, we hypothesized that local cell populations might additionally physically interact with the implanted BAG particles and respond differently than to just the ionic stimuli. We therefore studied the biological effect of two BAG types (45S5 and 1393) applied to human mesenchymal stromal cells (hMSCs) in three distinct presentation modes: (a) direct contact; and to dissolution products in (b) 2D, and (c) 3D culture. We furthermore investigated how the dose-dependence of these BAG particles, in concentrations ranging from 0.1 to 2.5 w/v %, influenced hMSC metabolic activity, proliferation, and cell spreading. These cellular functions were significantly hampered when hMSCs were exposed to high concentrations of either glasses, but the effects were more pronounced in the 45S5 groups and when the cells were in direct contact with the BAGs. Furthermore the biological effect of 1393 BAG outperformed that of 45S5 BAG in all tested presentation modes. These outcomes highlight the importance of investigating cell–BAG interactions in experimental set-ups that recapitulate host cell interactions with BAG particles.
Haro Durand LA, Vargas GE, Vera-Mesones R, et al., 2017, In Vitro Human Umbilical Vein Endothelial Cells Response to Ionic Dissolution Products from Lithium-Containing 45S5 Bioactive Glass, Materials, Vol: 10, ISSN: 1996-1944
Since lithium (Li+) plays roles in angiogenesis, the localized and controlled release of Li+ ions from bioactive glasses (BGs) represents a promising alternative therapy for the regeneration and repair of tissues with a high degree of vascularization. Here, microparticles from a base 45S5 BG composition containing (wt %) 45% SiO2, 24.5% Na2O, 24.5% CaO, and 6% P2O5, in which Na2O was partially substituted by 5% Li2O (45S5.5Li), were obtained. The results demonstrate that human umbilical vein endothelial cells (HUVECs) have greater migratory and proliferative response and ability to form tubules in vitro after stimulation with the ionic dissolution products (IDPs) of the 45S5.5Li BG. The results also show the activation of the canonical Wnt/β-catenin pathway and the increase in expression of proangiogenic cytokines insulin like growth factor 1 (IGF1) and transforming growth factor beta (TGFβ). We conclude that the IDPs of 45S5.5Li BG would act as useful inorganic agents to improve tissue repair and regeneration, ultimately stimulating HUVECs behavior in the absence of exogenous growth factors.
Moura D, Souza MT, Liverani L, et al., 2017, Development of a bioactive glass-polymer composite for wound healing applications, MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Vol: 76, Pages: 224-232, ISSN: 0928-4931
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- Citations: 62
Bertolla L, Dlouhy I, Tatarko P, et al., 2017, Pressureless spark plasma-sintered Bioglass® 45S5 with enhanced mechanical properties and stress-induced new phase formation, JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, Vol: 37, Pages: 2727-2736, ISSN: 0955-2219
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- Citations: 15
Germaini M-M, Detsch R, Gruenewald A, et al., 2017, Osteoblast and osteoclast responses to A/B type carbonate-substituted hydroxyapatite ceramics for bone regeneration, BIOMEDICAL MATERIALS, Vol: 12, ISSN: 1748-6041
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- Citations: 50
Boccaccini AR, 2017, Editorial Note, MATERIALS LETTERS, Vol: 197, Pages: 249-249, ISSN: 0167-577X
Fiocco L, Elsayed H, Badocco D, et al., 2017, Direct ink writing of silica-bonded calcite scaffolds from preceramic polymers and fillers, BIOFABRICATION, Vol: 9, ISSN: 1758-5082
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- Citations: 27
Zehnder T, Boccaccini AR, Detsch R, 2017, Biofabrication of a co-culture system in an osteoid-like hydrogel matrix, BIOFABRICATION, Vol: 9, ISSN: 1758-5082
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- Citations: 29
Macias-Andres VI, Li W, Aguilar-Reyes EA, et al., 2017, Preparation and characterization of 45S5 bioactive glass-based scaffolds loaded with PHBV microspheres with daidzein release function, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol: 105, Pages: 1765-1774, ISSN: 1549-3296
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- Citations: 11
Demir M, Ramos-Rivera L, Silva R, et al., 2017, Zein-based composites in biomedical applications, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol: 105, Pages: 1656-1665, ISSN: 1549-3296
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- Citations: 56
Hoehlinger M, Heise S, Wagener V, et al., 2017, Developing surface pre-treatments for electrophoretic deposition of biofunctional chitosan-bioactive glass coatings on a WE43 magnesium alloy, APPLIED SURFACE SCIENCE, Vol: 405, Pages: 441-448, ISSN: 0169-4332
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- Citations: 31
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