Summary
Alan Boobis received a Bachelor's degree in pharmacology in 1971 from the University of Glasgow (UK). In 1974 he received a PhD degree in pharmacology from the University of Glasgow (UK) working in the area of drug metabolism. His doctoral work involved studies of the influence of changes in hemodynamics in the liver on drug disposition and the effects of lipid peroxidation on P450 integrity. Professor Boobis then worked as a Fogarty Visiting Fellow for two years with Dr Dan Nebert at the National Institutes of Health (Bethesda, MD). During this time he studied the effects of modulating factors on benzo[a[pyrene DNA adduction, and was also involved in an investigation of genetic and developmental factors on P450 expression and activity. In 1976 he joined the department of Clinical Pharmacology at what was then the Royal Postgraduate Medical School (London, UK), as an MRC research training fellow. He was then appointed to a tenured lectureship and subsequently promoted to Professor of Biochemical Pharmacology, his current position (at what is now Imperial College London). He is now also Director of the Toxicology Unit (funded by PHE & DH) in the Faculty of Medicine at Imperial College London. His current research interests include mechanistic toxicology, drug metabolism, biomarker discovery in toxicology, using protein-based approaches and the application of this knowledge in risk assessment. He has published over 220 original research papers and is former Editor-in-Chief, now emeritus editor, of Food and Chemical Toxicology. He is a current or past member of a number of national and international grant review and advisory committees. Previously, he was deputy chair of the U.K. Advisory Committee on Pesticides (1999-2002) and is a former member of the UK Committees on Carcinogenicity and on Toxicity (deputy chair), the HPA Board Sub-Committee for Radiation, Chemical and Environmental Hazards and the EFSA Panel on Plant Protection Products and their Residues (vice-chair) and the EFSA Panel on Contaminants in Food and Feed. He is currently a member of several IPCS working groups, JECFA (chair), JMPR (alternating chair), and the Committee on the Adverse Effects of Air Pollution. He is a member and former chair of the Board of Trustees and the Executive Committee of ILSI HESI, vice-president of ILSI Europe and a member of the Board of Trustees of ILSI. He is involved in several HESI and ILSI Europe projects. He received an OBE for his work on the risk assessment of pesticides in 2003. He is an Honorary Member of EUROTOX, recipient of the EUROTOX Merit Award, The British Toxicology Society John Barnes Prize Lecture and the Royal Society of Chemistry Toxicology Award. He is also a Fellow of the British Toxicology Society and a Fellow of the Society of Biology.
Selected Publications
Journal Articles
Boobis A, Budinsky R, Collie S, et al., 2011, Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessment., Crit Rev Toxicol., Vol:41, Pages:369-383
Boobis AR, Cohen SM, Dellarco V, et al., 2006, IPCS framework for analyzing the relevance of a cancer mode of action for humans, Critical Reviews in Toxicology, Vol:36, ISSN:1040-8444, Pages:781-792
Boobis AR, Doe JE, Heinrich-Hirsch B, et al., 2008, IPCS framework for analyzing the relevance of a noncancer mode of action for humans, Critical Reviews in Toxicology, Vol:38, ISSN:1040-8444, Pages:87-96
Edwards RJ, Adams DA, Watts PS, et al., 1998, Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans, Biochemical Pharmacology, Vol:56, ISSN:0006-2952, Pages:377-387
BOOBIS AR, LYNCH AM, MURRAY S, et al., 1994, CYP1A2-CATALYZED CONVERSION OF DIETARY HETEROCYCLIC AMINES TO THEIR PROXIMATE CARCINOGENS IS THEIR MAJOR ROUTE OF METABOLISM IN HUMANS, Cancer Research, Vol:54, ISSN:0008-5472, Pages:89-94
SESARDIC D, BOOBIS AR, MURRAY BP, et al., 1990, FURAFYLLINE IS A POTENT AND SELECTIVE INHIBITOR OF CYTOCHROME-P450IA2 IN MAN, British Journal of Clinical Pharmacology, Vol:29, ISSN:0306-5251, Pages:651-663
TEE LBG, BOOBIS AR, HUGGETT AC, et al., 1986, REVERSAL OF ACETAMINOPHEN TOXICITY IN ISOLATED HAMSTER HEPATOCYTES BY DITHIOTHREITOL, Toxicology and Applied Pharmacology, Vol:83, ISSN:0041-008X, Pages:294-314
TEE LGB, BOOBIS AR, DAVIES DS, 1986, N-ACETYLCYSTEINE FOR PARACETAMOL OVERDOSE, The Lancet, Vol:1, ISSN:0140-6736, Pages:331-332