Imperial College London

Professor Alan Boobis OBE

Faculty of MedicineNational Heart & Lung Institute

Emeritus Professor of Toxicology
 
 
 
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Contact

 

a.boobis Website

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

579 results found

Barile FA, Berry SC, Blaauboer B, Boobis A, Bolt H, Borgert CJ, Dekant W, Dietrich D, Domingo JL, Gori GB, Greim H, Hengstler J, Kacew S, Marquardt H, Pelkonen O, Savolainen K, Heslop-Harrison P, Tsatsakis A, Vermeulen NPet al., 2021, Critique of the "Comment" etitled "Pyrethroid exposure: not so harmless after all" by Demeneix et al. (2020) published in the lancet diabetes endocrinology" (vol 340, pg 1, 2021), TOXICOLOGY LETTERS, Vol: 346, Pages: 57-57, ISSN: 0378-4274

Journal article

Barile FA, Berry SC, Blaauboer B, Boobis A, Bolt H, Borgert CJ, Dekant W, Dietrich D, Domingo JL, Gori GB, Greim H, Hengstler J, Kacew S, Marquardt H, Pelkonen O, Savolainen K, Heslop-Harrison P, Tsatsakis A, Vermeulen NPet al., 2021, Critique of the "Comment" etitled "Pyrethroid exposure: Not so harmless after all" by Demeneix et al. (2020) published in the lancet diabetes endocrinology, TOXICOLOGY LETTERS, Vol: 340, Pages: 1-3, ISSN: 0378-4274

Journal article

Nyakutsikwa B, Britton J, Bogdanovica I, Boobis A, Langley Tet al., 2021, Characterising vaping products in the United Kingdom: an analysis of Tobacco Products Directive notification data, ADDICTION, Vol: 116, Pages: 2521-2528, ISSN: 0965-2140

Journal article

Firman JW, Punt A, Cronin MTD, Boobis AR, Wilks MF, Hepburn PA, Thiel A, Fussell KCet al., 2021, Exploring the Potential of ToxCast Data in Supporting Read-Across for Evaluation of Food Chemical Safety, CHEMICAL RESEARCH IN TOXICOLOGY, Vol: 34, Pages: 300-312, ISSN: 0893-228X

Journal article

Fenton SE, Ducatman A, Boobis A, DeWitt JC, Lau C, Ng C, Smith JS, Roberts SMet al., 2020, Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research, ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, Vol: 40, Pages: 606-630, ISSN: 0730-7268

Journal article

Kumar V, Boobis AR, Moretto A, 2020, Test and Risk Assessment Strategies for combined exposure to multiple chemicals, FOOD AND CHEMICAL TOXICOLOGY, Vol: 144, ISSN: 0278-6915

Journal article

Sewell F, Kimber I, Boobis AR, 2020, Use of the kinetically-derived maximum dose: Opportunities for delivering 3Rs benefits, REGULATORY TOXICOLOGY AND PHARMACOLOGY, Vol: 116, ISSN: 0273-2300

Journal article

Whaley P, Aiassa E, Beausoleil C, Beronius A, Bilotta G, Boobis A, de Vries R, Hanberg A, Hoffmann S, Hunt N, Halsall C, Kwiatkowski CF, Lam J, Lipworth S, Martin O, Randall N, Rhomberg L, Rooney AA, Schunemann HJ, Wikoff D, Wolffe T, Halsall Cet al., 2020, Recommendations for the conduct of systematic reviews in toxicology and environmental health research (COSTER), ENVIRONMENT INTERNATIONAL, Vol: 143, ISSN: 0160-4120

Journal article

Autrup H, Barile FA, Berry SC, Blaauboer BJ, Boobis A, Bolt H, Borgert CJ, Dekant W, Dietrich D, Domingo JL, Gori GB, Greim H, Hengstler J, Kacew S, Marquardt H, Pelkonen O, Savolainen K, Heslop-Harrison P, Vermeulen NPet al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, TOXICOLOGY LETTERS, Vol: 331, Pages: 259-264, ISSN: 0378-4274

Journal article

Autrup H, Barile FA, Berry SC, Blaauboer BJ, Boobis A, Bolt H, Borgert CJ, Dekant W, Dietrich D, Domingo JL, Gori GB, Greim H, Hengstler J, Kacew S, Marquardt H, Pelkonen O, Savolainen K, Heslop-Harrison P, Vermeulen NPet al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, TOXICOLOGY IN VITRO, Vol: 67, ISSN: 0887-2333

Journal article

Autrup H, Barile FA, Berry SC, Blaauboer BJ, Boobis A, Bolt H, Borgert CJ, Dekant W, Dietrich D, Domingo JL, Gori GB, Greim H, Hengstler J, Kacew S, Marquardt H, Pelkonen O, Savolainen K, Heslop-Harrison P, Vermeulen NPet al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, Vol: 78, ISSN: 1382-6689

Journal article

Autrup H, Barile FA, Berry SC, Blaauboer BJ, Boobis A, Bolt H, Hengstler J, Borgert CJ, Dekant W, Dietrich D, Domingo JL, Gori GB, Greim H, Kacew S, Marquardt H, Pelkonen O, Savolainen K, Heslop-Harrison P, Vermeulen NPet al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, FOOD AND CHEMICAL TOXICOLOGY, Vol: 142, ISSN: 0278-6915

Journal article

Autrup H, Barile FA, Berry SC, Blaauboer BJ, Boobis A, Bolt H, Borgert CJ, Dekant W, Dietrich D, Domingo JL, Gori GB, Greim H, Hengstler J, Kacew S, Marquardt H, Pelkonen O, Savolainen K, Heslop-Harrison P, Vermeulen NPet al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, CHEMICO-BIOLOGICAL INTERACTIONS, Vol: 326, ISSN: 0009-2797

Journal article

Autrup H, Barile FA, Berry SC, Blaauboer BJ, Boobis A, Bolt H, Borgert CJ, Dekant W, Dietrich D, Domingo JL, Gori GB, Greim H, Hengstler J, Kacew S, Marquardt H, Pelkonen O, Savolainen K, Heslop-Harrison P, Vermeulen NPet al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, Vol: 83, Pages: 485-494, ISSN: 1528-7394

Journal article

Mahony C, Ashton RS, Birk B, Boobis AR, Cull T, Daston GP, Ewart L, Knudsen TB, Manou I, Maurer-Stroh S, Margiotta-Casaluci L, Muller BP, Nordlund P, Roberts RA, Steger-Hartmann T, Vandenbossche E, Viant MR, Vinken M, Whelan M, Zvonimir Z, Cronin MTDet al., 2020, New ideas for non-animal approaches to predict repeated-dose systemic toxicity: Report from an EPAA Blue Sky Workshop, REGULATORY TOXICOLOGY AND PHARMACOLOGY, Vol: 114, ISSN: 0273-2300

Journal article

Autrup H, Barile FA, Berry SC, Blaauboer BJ, Boobis A, Bolt H, Borgert CJ, Dekant W, Dietrich D, Domingo JL, Gori GB, Greim H, Hengstler J, Kacew S, Marquardt H, Pelkonen O, Savolainen K, Heslop-Harrison P, Vermeulen NPet al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to evaluate the risk of the S-EDCs?, ARCHIVES OF TOXICOLOGY, Vol: 94, Pages: 2549-2557, ISSN: 0340-5761

Journal article

Autrup H, Barile FA, Colin Berry S, Blaauboer BJ, Boobis A, Bolt H, Borgert CJ, Dekant W, Dietrich D, Domingo JL, Batta Gori G, Greim H, Hengstler J, Kacew S, Marquardt H, Pelkonen O, Savolainen K, Heslop-Harrison P, Vermeulen NPet al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, Computational Toxicology, Vol: 14, ISSN: 2468-1113

Theoretically, both synthetic endocrine disrupting chemicals (S-EDCs) and natural (exogenous and endogenous) endocrine disrupting chemicals (N-EDCs) can interact with endocrine receptors and disturb hormonal balance. However, compared to endogenous hormones, S-EDCs are only weak partial agonists with receptor affinities several orders of magnitude lower than S-EDCs. Thus, to elicit observable effects, S-EDCs require considerably higher concentrations to attain sufficient receptor occupancy or to displace natural hormones and other endogenous ligands. Significant exposures to exogenous N-EDCs may result from ingestion of foods such as soy-based diets, green tea and sweet mustard. While their potencies are lower as compared to natural endogenous hormones, they usually are considerably more potent than S-EDCs. Effects of exogenous N-EDCs on the endocrine system were observed at high dietary intakes. A causal relation between their mechanism of action and these effects is established and biologically plausible. In contrast, the assumption that the much lower human exposures to S-EDCs may induce observable endocrine effects is not plausible. Hence, it is not surprising that epidemiological studies searching for an association between S-EDC exposure and health effects have failed. Regarding testing for potential endocrine effects, a scientifically justified screen should use in vitro tests to compare potencies of S-EDCs with those of reference N-EDCs. When the potency of the S-EDC is similar or smaller than that of the N-EDC, further testing in laboratory animals and regulatory consequences are not warranted.

Journal article

Punt A, Firman J, Boobis A, Cronin M, Gosling JP, Wilks MF, Hepburn PA, Thiel A, Fussell KCet al., 2020, Potential of ToxCast Data in the Safety Assessment of Food Chemicals, TOXICOLOGICAL SCIENCES, Vol: 174, Pages: 326-340, ISSN: 1096-6080

Journal article

Parish ST, Aschner M, Casey W, Corvaro M, Embry MR, Fitzpatrick S, Kidd D, Kleinstreuer NC, Lima BS, Settivari RS, Wolf DC, Yamazaki D, Boobis Aet al., 2020, An evaluation framework for new approach methodologies (NAMs) for human health safety assessment, REGULATORY TOXICOLOGY AND PHARMACOLOGY, Vol: 112, ISSN: 0273-2300

Journal article

Felter SP, Boobis AR, Botham PA, Brousse A, Greim H, Hollnagel HM, Sauer UGet al., 2020, Hazard identification, classification, and risk assessment of carcinogens: too much or too little? - Report of an ECETOC workshop, CRITICAL REVIEWS IN TOXICOLOGY, Vol: 50, Pages: 72-95, ISSN: 1040-8444

Journal article

Vinken M, Kramer N, Allen TEH, Hoffmans Y, Thatcher N, Levorato S, Traussnig H, Schulte S, Boobis A, Thiel A, Rietjens IMCMet al., 2020, The use of adverse outcome pathways in the safety evaluation of food additives, ARCHIVES OF TOXICOLOGY, Vol: 94, Pages: 959-966, ISSN: 0340-5761

Journal article

Punt A, Boobis A, Cronin MT, Etter S, Firman J, Forsberg K, Gosling JP, Hepburn PA, Thiel A, Traussnig H, Wilks MF, Fussell Ket al., 2019, High throughput screening in the risk and benefit assessment of food ingredients, 55th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology - Science Providing Solutions, Publisher: ELSEVIER IRELAND LTD, Pages: S30-S30, ISSN: 0378-4274

Conference paper

Schilter B, Burnett K, Eskes C, Geurts L, Jacquet M, Kirchnawy C, Oldring P, Pieper G, Pinter E, Tacker M, Traussnig H, Van Herwijnen P, Boobis Aet al., 2019, Value and limitation of in vitro bioassays to support the application of the threshold of toxicological concern to prioritise unidentified chemicals in food contact materials, FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, Vol: 36, Pages: 1903-1936, ISSN: 1944-0049

Journal article

Desprez B, Birk B, Blaauboer B, Boobis A, Carmichael P, Cronin MTD, Curie R, Daston G, Hubesch B, Jennings P, Klaric M, Kroese D, Mahony C, Ouedraogo G, Piersma A, Richarz A-N, Schwarz M, van Benthem J, van de Waters B, Vinken Met al., 2019, A mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity, TOXICOLOGY IN VITRO, Vol: 59, Pages: 44-50, ISSN: 0887-2333

Journal article

Kramer NI, Hoffmans Y, Wu S, Thiel A, Thatcher N, Allen TEH, Levorato S, Traussnig H, Schulte S, Boobis A, Rietjens IMCM, Vinken Met al., 2019, Characterizing the coverage of critical effects relevant in the safety evaluation of food additives by AOPs, ARCHIVES OF TOXICOLOGY, Vol: 93, Pages: 2115-2125, ISSN: 0340-5761

There is considerable interest in adverse outcome pathways (AOPs) as a means of organizing biological and toxicological information to assist in data interpretation and method development. While several chemical sectors have shown considerable progress in applying this approach, this has not been the case in the food sector. In the present study, safety evaluation reports of food additives listed in Annex II of Regulation (EC) No 1333/2008 of the European Union were screened to qualitatively and quantitatively characterize toxicity induced in laboratory animals. The resulting database was used to identify the critical adverse effects used for risk assessment and to investigate whether food additives share common AOPs. Analysis of the database revealed that often such scrutiny of AOPs was not possible or necessary. For 69% of the food additives, the report did not document any adverse effects in studies based on which the safety evaluation was performed. For the remaining 31% of the 326 investigated food additives, critical adverse effects and related points of departure for establishing health-based guidance values could be identified. These mainly involved effects on the liver, kidney, cardiovascular system, lymphatic system, central nervous system and reproductive system. AOPs are available for many of these apical endpoints, albeit to different degrees of maturity. For other adverse outcomes pertinent to food additives, including gastrointestinal irritation and corrosion, AOPs are lacking. Efforts should focus on developing AOPs for these particular endpoints.

Journal article

Doe JE, Boobis AR, Dellarco V, Fenner-Crisp PA, Moretto A, Pastoor TP, Schoeny RS, Seed JG, Wolf DCet al., 2019, Chemical carcinogenicity revisited 2: Current knowledge of carcinogenesis shows that categorization as a carcinogen or non-carcinogen is not scientifically credible, REGULATORY TOXICOLOGY AND PHARMACOLOGY, Vol: 103, Pages: 124-129, ISSN: 0273-2300

Journal article

Wolf DC, Cohen SM, Boobis AR, Dellarco VL, Fenner-Crisp PA, Moretto A, Pastoor TP, Schoeny RS, Seed JG, Doe JEet al., 2019, Chemical carcinogenicity revisited 1: A unified theory of carcinogenicity based on contemporary knowledge, REGULATORY TOXICOLOGY AND PHARMACOLOGY, Vol: 103, Pages: 86-92, ISSN: 0273-2300

Journal article

Cohen SM, Boobis AR, Dellarco VL, Doe JE, Fenner-Crisp PA, Moretto A, Pastoor TP, Schoeny RS, Seed JG, Wolf DCet al., 2019, Chemical carcinogenicity revisited 3: Risk assessment of carcinogenic potential based on the current state of knowledge of carcinogenesis in humans, REGULATORY TOXICOLOGY AND PHARMACOLOGY, Vol: 103, Pages: 100-105, ISSN: 0273-2300

Journal article

Arcella D, Boobis A, Cressey P, Erdely H, Fattori V, Leblanc J-C, Lipp M, Reuss R, Scheid S, Tritscher A, Van der Velde-Koerts T, Verger Pet al., 2019, Harmonized methodology to assess chronic dietary exposure to residues from compounds used as pesticide and veterinary drug, CRITICAL REVIEWS IN TOXICOLOGY, Vol: 49, Pages: 1-10, ISSN: 1040-8444

Journal article

Pires SM, Boue G, Boobis A, Eneroth H, Hoekstra J, Membre J-M, Persson IM, Poulsen M, Ruzante J, van Klaveren J, Thomsen ST, Nauta MJet al., 2019, Risk Benefit Assessment of foods: Key findings from an international workshop, FOOD RESEARCH INTERNATIONAL, Vol: 116, Pages: 859-869, ISSN: 0963-9969

Journal article

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