Imperial College London

Professor Alan Boobis OBE

Faculty of MedicineNational Heart & Lung Institute

Emeritus Professor of Toxicology
 
 
 
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Contact

 

a.boobis Website

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

596 results found

Löwik MR, Astrup A, Boobis AR, Calder PC, Daniel H, Rietjens IM, Sievenpiper JL, Verhagen Het al., 2024, Risk assessment of nutrients: There must be a threshold for their effects., Regul Toxicol Pharmacol, Vol: 146

Nutrients serve physiological functions in a dose-dependent manner and that needs to be recognized in risk assessment. An example of the consequences of not properly considering this can be seen in a recent assessment by the European Food Safety Authority (EFSA). EFSA concluded in 2022 that the intake of added and free sugars should be "as low as possible in the context of a nutritionally adequate diet". That conclusion of EFSA is based on the effects on two surrogate endpoints for an adverse effect found in randomized controlled trials with high sugars intake levels: fasting glucose and fasting triglycerides. The lowest intake levels in these trials were around 10 energy% and at this intake level there were no adverse effects on the two outcomes. This indicates that the adverse effects of sugars have an observable threshold value for these two endpoints. The most appropriate interpretation from the vast amount of data is that currently no definitive conclusion can be drawn on the tolerable upper intake level for dietary sugars. Therefore, EFSA's own guidance would lead to the conclusion that the available data do not allow the setting of an upper limit for added sugars and hence, that more robust data are required to identify the threshold value for intake of sugars.

Journal article

Dyson E, Helbig R, Avermaete T, Halliwell K, Calder PC, Brown LR, Ingram J, Popping B, Verhagen H, Boobis AR, Guelinckx I, Dye L, Boyle Net al., 2023, Impacts of the Ukraine-Russia Conflict on the Global Food Supply Chain and Building Future ResilienceDie Auswirkungen des Ukraine-Russland-Konflikts auf die globale Lebensmittelwarenkette und der Aufbau von kunftiger Resilienz, EUROCHOICES, Vol: 22, Pages: 14-19, ISSN: 1478-0917

Journal article

Escher SE, Felter SP, Hollnagel H, Boobis AR, Yang C, Rathman J, Cronin MTD, Batke Met al., 2023, Workshop Report on the Evaluation of the Updated and Expanded Carcinogen Database to Support Derivation of Threshold of Toxicological Concern Values for DNA-Reactive Carcinogens, ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, Vol: 40, Pages: 341-349, ISSN: 1868-596X

Journal article

Hollnagel HM, Bellion P, Buist H, Gadhia S, Lovell DP, Melching-Kollmuss S, Worth A, Boobis ARet al., 2022, Introduction to TTC - concept, databases, excluded substances and sources of uncertainty, 16th International Congress of Toxicology (ICT) - Uniting in Toxicology, Publisher: ELSEVIER IRELAND LTD, Pages: S8-S8, ISSN: 0378-4274

Conference paper

Boobis A, 2022, Synthesis and integration of epidemiological and toxicological evidence, 16th International Congress of Toxicology (ICT) - Uniting in Toxicology, Publisher: ELSEVIER IRELAND LTD, Pages: S47-S47, ISSN: 0378-4274

Conference paper

Doe JE, Boobis AR, Cohen SM, Dellarco VL, Fenner-Crisp PA, Moretto A, Pastoor TP, Schoeny RS, Seed JG, Wolf DCet al., 2022, A new approach to the classification of carcinogenicity, ARCHIVES OF TOXICOLOGY, Vol: 96, Pages: 2419-2428, ISSN: 0340-5761

Journal article

Knowles ME, Anelich LE, Boobis AR, Popping Bet al., 2022, Preface, Present Knowledge in Food Safety: A Risk-Based Approach through the Food Chain, Pages: xxxi-xxxi

Journal article

Knowles ME, Anelich LE, Boobis AR, Popping Bet al., 2022, Present Knowledge in Food Safety: A Risk-Based Approach Through the Food Chain, ISBN: 9780128231548

Present Knowledge in Food Safety: A Risk-Based Approach Through the Food Chain presents approaches for exposure-led risk assessment and the management of changes in the chemical, pathogenic microbiological and physical (radioactivity) contamination of ’food’ at all key stages of production, from farm to consumption. This single volume resource introduces scientific advances at all stages of the production to improve reliability, predictability and relevance of food safety assessments for the protection of public health. This book is aimed at a diverse audience, including graduate and post-graduate students in food science, toxicology, microbiology, medicine, public health, and related fields. The book's reach also includes government agencies, industrial scientists, and policymakers involved in food risk analysis.

Book

Tan Y-M, Barton HA, Boobis A, Brunner R, Clewell H, Cope R, Dawson J, Domoradzki J, Egeghy P, Gulati P, Ingle B, Kleinstreuer N, Lowe K, Lowit A, Mendez E, Miller D, Minucci J, Nguyen J, Paini A, Perron M, Phillips K, Qian H, Ramanarayanan T, Sewell F, Villanueva P, Wambaugh J, Embry Met al., 2021, Opportunities and challenges related to saturation of toxicokinetic processes: Implications for risk assessment, REGULATORY TOXICOLOGY AND PHARMACOLOGY, Vol: 127, ISSN: 0273-2300

Journal article

Doe JE, Boobis AR, Cohen SM, Dellarco VL, Fenner-Crisp PA, Moretto A, Pastoor TP, Schoeny RS, Seed JG, Wolf DCet al., 2021, The codification of hazard and its impact on the hazard versus risk controversy, ARCHIVES OF TOXICOLOGY, Vol: 95, Pages: 3611-3621, ISSN: 0340-5761

Journal article

Barile FA, Berry C, Blaauboer B, Boobis A, Bolt HM, Borgert C, Dekant W, Dietrich D, Domingo JL, Galli CL, Gori GB, Greim H, Hengstler JG, Heslop-Harrison P, Kacew S, Marquardt H, Mally A, Pelkonen O, Savolainen K, Testai E, Tsatsakis A, Vermeulen NPet al., 2021, The EU chemicals strategy for sustainability: in support of the BfR position, ARCHIVES OF TOXICOLOGY, Vol: 95, Pages: 3133-3136, ISSN: 0340-5761

Journal article

Doerr B, Boobis A, 2021, The UK Committee on Toxicity (COT) and on Carcinogenicity (COC) of Chemicals in Food, Consumer Products and the Environment: Guidance for synthesising and integration of epidemiological and toxicological evidence, 56th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology of the Next Generation, Publisher: ELSEVIER IRELAND LTD, Pages: S220-S220, ISSN: 0378-4274

Conference paper

Boobis AR, Pettit SD, 2021, Individualized toxicity is the future of risk assessment, 56th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology of the Next Generation, Publisher: ELSEVIER IRELAND LTD, Pages: S11-S11, ISSN: 0378-4274

Conference paper

Boobis AR, 2021, Current challenges in a paradigm shift for cancer risk assessment, 56th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology of the Next Generation, Publisher: ELSEVIER IRELAND LTD, Pages: S40-S40, ISSN: 0378-4274

Conference paper

Nyakutsikwa B, Britton J, Bogdanovica I, Boobis A, Langley Tet al., 2021, Characterising vaping products in the United Kingdom: an analysis of Tobacco Products Directive notification data, ADDICTION, Vol: 116, Pages: 2521-2528, ISSN: 0965-2140

Journal article

Barile FA, Berry SC, Blaauboer B, Boobis A, Bolt H, Borgert CJ, Dekant W, Dietrich D, Domingo JL, Gori GB, Greim H, Hengstler J, Kacew S, Marquardt H, Pelkonen O, Savolainen K, Heslop-Harrison P, Tsatsakis A, Vermeulen NPet al., 2021, Critique of the "Comment" etitled "Pyrethroid exposure: not so harmless after all" by Demeneix et al. (2020) published in the lancet diabetes endocrinology" (vol 340, pg 1, 2021), TOXICOLOGY LETTERS, Vol: 346, Pages: 57-57, ISSN: 0378-4274

Journal article

Barile FA, Berry SC, Blaauboer B, Boobis A, Bolt H, Borgert CJ, Dekant W, Dietrich D, Domingo JL, Gori GB, Greim H, Hengstler J, Kacew S, Marquardt H, Pelkonen O, Savolainen K, Heslop-Harrison P, Tsatsakis A, Vermeulen NPet al., 2021, Critique of the "Comment" etitled "<i>Pyrethroid exposure</i>: Not so harmless after all" by Demeneix et al. (2020) published in the lancet diabetes endocrinology, TOXICOLOGY LETTERS, Vol: 340, Pages: 1-3, ISSN: 0378-4274

Journal article

Fenton SE, Ducatman A, Boobis A, DeWitt JC, Lau C, Ng C, Smith JS, Roberts SMet al., 2021, Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research, ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, Vol: 40, Pages: 606-630, ISSN: 0730-7268

Journal article

Firman JW, Punt A, Cronin MTD, Boobis AR, Wilks MF, Hepburn PA, Thiel A, Fussell KCet al., 2021, Exploring the Potential of ToxCast Data in Supporting Read-Across for Evaluation of Food Chemical Safety, CHEMICAL RESEARCH IN TOXICOLOGY, Vol: 34, Pages: 300-312, ISSN: 0893-228X

Journal article

Autrup H, Barile FA, Berry SC, Blaauboer BJ, Boobis A, Bolt H, Borgert CJ, Dekant W, Dietrich D, Domingo JL, Gori GB, Greim H, Hengstler J, Kacew S, Marquardt H, Pelkonen O, Savolainen K, Heslop-Harrison P, Vermeulen NPet al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, TOXICOLOGY LETTERS, Vol: 331, Pages: 259-264, ISSN: 0378-4274

Journal article

Sewell F, Kimber I, Boobis AR, 2020, Use of the kinetically-derived maximum dose: Opportunities for delivering 3Rs benefits, REGULATORY TOXICOLOGY AND PHARMACOLOGY, Vol: 116, ISSN: 0273-2300

Journal article

Whaley P, Aiassa E, Beausoleil C, Beronius A, Bilotta G, Boobis A, de Vries R, Hanberg A, Hoffmann S, Hunt N, Halsall C, Kwiatkowski CF, Lam J, Lipworth S, Martin O, Randall N, Rhomberg L, Rooney AA, Schunemann HJ, Wikoff D, Wolffe T, Halsall Cet al., 2020, Recommendations for the conduct of systematic reviews in toxicology and environmental health research (COSTER), ENVIRONMENT INTERNATIONAL, Vol: 143, ISSN: 0160-4120

Journal article

Kumar V, Boobis AR, Moretto A, 2020, Test and Risk Assessment Strategies for combined exposure to multiple chemicals, FOOD AND CHEMICAL TOXICOLOGY, Vol: 144, ISSN: 0278-6915

Journal article

Autrup H, Barile FA, Berry SC, Blaauboer BJ, Boobis A, Bolt H, Borgert CJ, Dekant W, Dietrich D, Domingo JL, Gori GB, Greim H, Hengstler J, Kacew S, Marquardt H, Pelkonen O, Savolainen K, Heslop-Harrison P, Vermeulen NPet al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, TOXICOLOGY IN VITRO, Vol: 67, ISSN: 0887-2333

Journal article

Autrup H, Barile FA, Berry SC, Blaauboer BJ, Boobis A, Bolt H, Borgert CJ, Dekant W, Dietrich D, Domingo JL, Gori GB, Greim H, Hengstler J, Kacew S, Marquardt H, Pelkonen O, Savolainen K, Heslop-Harrison P, Vermeulen NPet al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, CHEMICO-BIOLOGICAL INTERACTIONS, Vol: 326, ISSN: 0009-2797

Journal article

Autrup H, Barile FA, Berry SC, Blaauboer BJ, Boobis A, Bolt H, Hengstler J, Borgert CJ, Dekant W, Dietrich D, Domingo JL, Gori GB, Greim H, Kacew S, Marquardt H, Pelkonen O, Savolainen K, Heslop-Harrison P, Vermeulen NPet al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, FOOD AND CHEMICAL TOXICOLOGY, Vol: 142, ISSN: 0278-6915

Journal article

Autrup H, Barile FA, Berry SC, Blaauboer BJ, Boobis A, Bolt H, Borgert CJ, Dekant W, Dietrich D, Domingo JL, Gori GB, Greim H, Hengstler J, Kacew S, Marquardt H, Pelkonen O, Savolainen K, Heslop-Harrison P, Vermeulen NPet al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, Vol: 78, ISSN: 1382-6689

Journal article

Autrup H, Barile FA, Berry SC, Blaauboer BJ, Boobis A, Bolt H, Borgert CJ, Dekant W, Dietrich D, Domingo JL, Gori GB, Greim H, Hengstler J, Kacew S, Marquardt H, Pelkonen O, Savolainen K, Heslop-Harrison P, Vermeulen NPet al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, Vol: 83, Pages: 485-494, ISSN: 1528-7394

Journal article

Mahony C, Ashton RS, Birk B, Boobis AR, Cull T, Daston GP, Ewart L, Knudsen TB, Manou I, Maurer-Stroh S, Margiotta-Casaluci L, Muller BP, Nordlund P, Roberts RA, Steger-Hartmann T, Vandenbossche E, Viant MR, Vinken M, Whelan M, Zvonimir Z, Cronin MTDet al., 2020, New ideas for non-animal approaches to predict repeated-dose systemic toxicity: Report from an EPAA Blue Sky Workshop, REGULATORY TOXICOLOGY AND PHARMACOLOGY, Vol: 114, ISSN: 0273-2300

Journal article

Autrup H, Barile FA, Berry SC, Blaauboer BJ, Boobis A, Bolt H, Borgert CJ, Dekant W, Dietrich D, Domingo JL, Gori GB, Greim H, Hengstler J, Kacew S, Marquardt H, Pelkonen O, Savolainen K, Heslop-Harrison P, Vermeulen NPet al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to evaluate the risk of the S-EDCs?, ARCHIVES OF TOXICOLOGY, Vol: 94, Pages: 2549-2557, ISSN: 0340-5761

Journal article

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