Publications
590 results found
Dyson E, Helbig R, Avermaete T, et al., 2023, Impacts of the Ukraine-Russia Conflict on the Global Food Supply Chain and Building Future ResilienceDie Auswirkungen des Ukraine-Russland-Konflikts auf die globale Lebensmittelwarenkette und der Aufbau von kunftiger Resilienz, EUROCHOICES, ISSN: 1478-0917
Escher SE, Felter SP, Hollnagel H, et al., 2022, Workshop report on the evaluation of the updated and expanded carcinogen database to support derivation of threshold of toxicological concern values for DNA reactive carcinogens., ALTEX
Threshold of toxicological concern (TTC) values are frequently used for compounds occurring at low concentrations in feed and food or as impurities in drugs. This workshop report addresses the emerging alternatives for deriving TTC values for DNA reactive carcinogens and evaluating the acceptability of the Cramer Class TTC values to be adequately protective for non-DNA reactive carcinogens.
Boobis A, 2022, Synthesis and integration of epidemiological and toxicological evidence, 16th International Congress of Toxicology (ICT) - Uniting in Toxicology, Publisher: ELSEVIER IRELAND LTD, Pages: S47-S47, ISSN: 0378-4274
Hollnagel HM, Bellion P, Buist H, et al., 2022, Introduction to TTC - concept, databases, excluded substances and sources of uncertainty, 16th International Congress of Toxicology (ICT) - Uniting in Toxicology, Publisher: ELSEVIER IRELAND LTD, Pages: S8-S8, ISSN: 0378-4274
Doe JE, Boobis AR, Cohen SM, et al., 2022, A new approach to the classification of carcinogenicity, ARCHIVES OF TOXICOLOGY, Vol: 96, Pages: 2419-2428, ISSN: 0340-5761
Tan Y-M, Barton HA, Boobis A, et al., 2021, Opportunities and challenges related to saturation of toxicokinetic processes: Implications for risk assessment, REGULATORY TOXICOLOGY AND PHARMACOLOGY, Vol: 127, ISSN: 0273-2300
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- Citations: 7
Doe JE, Boobis AR, Cohen SM, et al., 2021, The codification of hazard and its impact on the hazard versus risk controversy, ARCHIVES OF TOXICOLOGY, Vol: 95, Pages: 3611-3621, ISSN: 0340-5761
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- Citations: 3
Doerr B, Boobis A, 2021, The UK Committee on Toxicity (COT) and on Carcinogenicity (COC) of Chemicals in Food, Consumer Products and the Environment: Guidance for synthesising and integration of epidemiological and toxicological evidence, 56th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology of the Next Generation, Publisher: ELSEVIER IRELAND LTD, Pages: S220-S220, ISSN: 0378-4274
Boobis AR, Pettit SD, 2021, Individualized toxicity is the future of risk assessment, 56th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology of the Next Generation, Publisher: ELSEVIER IRELAND LTD, Pages: S11-S11, ISSN: 0378-4274
Boobis AR, 2021, Current challenges in a paradigm shift for cancer risk assessment, 56th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology of the Next Generation, Publisher: ELSEVIER IRELAND LTD, Pages: S40-S40, ISSN: 0378-4274
Barile FA, Berry C, Blaauboer B, et al., 2021, The EU chemicals strategy for sustainability: in support of the BfR position, ARCHIVES OF TOXICOLOGY, Vol: 95, Pages: 3133-3136, ISSN: 0340-5761
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- Citations: 4
Barile FA, Berry SC, Blaauboer B, et al., 2021, Critique of the "Comment" etitled "Pyrethroid exposure: not so harmless after all" by Demeneix et al. (2020) published in the lancet diabetes endocrinology" (vol 340, pg 1, 2021), TOXICOLOGY LETTERS, Vol: 346, Pages: 57-57, ISSN: 0378-4274
Nyakutsikwa B, Britton J, Bogdanovica I, et al., 2021, Characterising vaping products in the United Kingdom: an analysis of Tobacco Products Directive notification data, ADDICTION, Vol: 116, Pages: 2521-2528, ISSN: 0965-2140
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- Citations: 3
Firman JW, Punt A, Cronin MTD, et al., 2021, Exploring the Potential of ToxCast Data in Supporting Read-Across for Evaluation of Food Chemical Safety, CHEMICAL RESEARCH IN TOXICOLOGY, Vol: 34, Pages: 300-312, ISSN: 0893-228X
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- Citations: 4
Barile FA, Berry SC, Blaauboer B, et al., 2021, Critique of the "Comment" etitled "Pyrethroid exposure: Not so harmless after all" by Demeneix et al. (2020) published in the lancet diabetes endocrinology, TOXICOLOGY LETTERS, Vol: 340, Pages: 1-3, ISSN: 0378-4274
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- Citations: 1
Fenton SE, Ducatman A, Boobis A, et al., 2020, Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research, ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, Vol: 40, Pages: 606-630, ISSN: 0730-7268
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- Citations: 242
Kumar V, Boobis AR, Moretto A, 2020, Test and Risk Assessment Strategies for combined exposure to multiple chemicals, FOOD AND CHEMICAL TOXICOLOGY, Vol: 144, ISSN: 0278-6915
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- Citations: 6
Sewell F, Kimber I, Boobis AR, 2020, Use of the kinetically-derived maximum dose: Opportunities for delivering 3Rs benefits, REGULATORY TOXICOLOGY AND PHARMACOLOGY, Vol: 116, ISSN: 0273-2300
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- Citations: 6
Whaley P, Aiassa E, Beausoleil C, et al., 2020, Recommendations for the conduct of systematic reviews in toxicology and environmental health research (COSTER), ENVIRONMENT INTERNATIONAL, Vol: 143, ISSN: 0160-4120
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- Citations: 39
Autrup H, Barile FA, Berry SC, et al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, TOXICOLOGY LETTERS, Vol: 331, Pages: 259-264, ISSN: 0378-4274
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- Citations: 12
Autrup H, Barile FA, Berry SC, et al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, TOXICOLOGY IN VITRO, Vol: 67, ISSN: 0887-2333
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- Citations: 12
Autrup H, Barile FA, Berry SC, et al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, Vol: 78, ISSN: 1382-6689
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- Citations: 12
Autrup H, Barile FA, Berry SC, et al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, FOOD AND CHEMICAL TOXICOLOGY, Vol: 142, ISSN: 0278-6915
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- Citations: 12
Autrup H, Barile FA, Berry SC, et al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, CHEMICO-BIOLOGICAL INTERACTIONS, Vol: 326, ISSN: 0009-2797
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- Citations: 1
Autrup H, Barile FA, Berry SC, et al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, Vol: 83, Pages: 485-494, ISSN: 1528-7394
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- Citations: 12
Mahony C, Ashton RS, Birk B, et al., 2020, New ideas for non-animal approaches to predict repeated-dose systemic toxicity: Report from an EPAA Blue Sky Workshop, REGULATORY TOXICOLOGY AND PHARMACOLOGY, Vol: 114, ISSN: 0273-2300
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- Citations: 17
Autrup H, Barile FA, Berry SC, et al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to evaluate the risk of the S-EDCs?, ARCHIVES OF TOXICOLOGY, Vol: 94, Pages: 2549-2557, ISSN: 0340-5761
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- Citations: 5
Autrup H, Barile FA, Colin Berry S, et al., 2020, Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, Computational Toxicology, Vol: 14, ISSN: 2468-1113
Theoretically, both synthetic endocrine disrupting chemicals (S-EDCs) and natural (exogenous and endogenous) endocrine disrupting chemicals (N-EDCs) can interact with endocrine receptors and disturb hormonal balance. However, compared to endogenous hormones, S-EDCs are only weak partial agonists with receptor affinities several orders of magnitude lower than S-EDCs. Thus, to elicit observable effects, S-EDCs require considerably higher concentrations to attain sufficient receptor occupancy or to displace natural hormones and other endogenous ligands. Significant exposures to exogenous N-EDCs may result from ingestion of foods such as soy-based diets, green tea and sweet mustard. While their potencies are lower as compared to natural endogenous hormones, they usually are considerably more potent than S-EDCs. Effects of exogenous N-EDCs on the endocrine system were observed at high dietary intakes. A causal relation between their mechanism of action and these effects is established and biologically plausible. In contrast, the assumption that the much lower human exposures to S-EDCs may induce observable endocrine effects is not plausible. Hence, it is not surprising that epidemiological studies searching for an association between S-EDC exposure and health effects have failed. Regarding testing for potential endocrine effects, a scientifically justified screen should use in vitro tests to compare potencies of S-EDCs with those of reference N-EDCs. When the potency of the S-EDC is similar or smaller than that of the N-EDC, further testing in laboratory animals and regulatory consequences are not warranted.
Punt A, Firman J, Boobis A, et al., 2020, Potential of ToxCast Data in the Safety Assessment of Food Chemicals, TOXICOLOGICAL SCIENCES, Vol: 174, Pages: 326-340, ISSN: 1096-6080
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- Citations: 10
Parish ST, Aschner M, Casey W, et al., 2020, An evaluation framework for new approach methodologies (NAMs) for human health safety assessment, REGULATORY TOXICOLOGY AND PHARMACOLOGY, Vol: 112, ISSN: 0273-2300
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- Citations: 53
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