Publications
597 results found
Verger PJP, Boobis AR, 2013, Reevaluate Pesticides for Food Security and Safety, SCIENCE, Vol: 341, Pages: 717-718, ISSN: 0036-8075
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- Citations: 106
Boobis A, Flari V, Gosling JP, et al., 2013, Interpretation of the margin of exposure for genotoxic carcinogens - Elicitation of expert knowledge about the form of the dose response curve at human relevant exposures, FOOD AND CHEMICAL TOXICOLOGY, Vol: 57, Pages: 106-118, ISSN: 0278-6915
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- Citations: 7
Boobis A, Chiodini A, Hoekstra J, et al., 2013, Critical appraisal of the assessment of benefits and risks for foods, 'BRAFO Consensus Working Group', FOOD AND CHEMICAL TOXICOLOGY, Vol: 55, Pages: 659-675, ISSN: 0278-6915
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- Citations: 30
Verbeke K, Bernalier A, Boobis A, et al., 2013, HOW TO ASSESS GASTROINTESTINAL HEALTH BENEFITS OF PREBIOTICS: FOCUSING ON 'MICROBIAL FERMENTATION AND METABOLISM', ANNALS OF NUTRITION AND METABOLISM, Vol: 63, Pages: 1580-1581, ISSN: 0250-6807
Alexander J, Benford D, Boobis A, et al., 2012, Risk assessment of contaminants in food and feed, EFSA Journal, Vol: 10
The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) carries out risk assessment on contaminants in food and feed. The presence of hazardous chemical contaminants or undesirable substances in food and feed is often unavoidable as these substances may occur ubiquitously or are of natural origin. Therefore, human and animal exposure to such substances is also unavoidable. The task of the CONTAM Panel is to assess whether or not exposure to a chemical contaminant in food is likely to be associated with adverse health effects in the European population. Similarly, the Panel assesses if the exposure to a contaminant in feed is likely to be associated with adverse health effects in farm animals, fish and pets in Europe, or to represent a risk to the consumer of foods of animal origin. In contrast to EFSA Panels dealing with regulated substances where inter alia applications are taken into account, the CONTAM Panel relies on scientific information that is in the public domain. EFSA often launches calls for data on occurrence of contaminants in food and feedstuffs where Member States and other interested stakeholders are invited to submit data. Whenever possible and required the CONTAM Panel establishes for a substance a health-based guidance value such as tolerable daily intake. For substances that are both genotoxic and carcinogenic, or for which the data are inadequate to establish a health-based guidance value, the margin of exposure approach is used. Recently the CONTAM Panel also used the threshold of toxicological concern approach. In addition, the CONTAM Panel considers inherent uncertainties in relation to objectives, exposure and hazard characterisation in its risk assessments. During 2003–2012, the CONTAM Panel published 107 scientific outputs (55 on food, 43 on feed, 9 on food and feed).
Boobis A, 2012, Does read across give enough certainty to ensure human health, 48th Congress of the European-Societies-of-Toxicology (EUROTOX), Publisher: ELSEVIER IRELAND LTD, Pages: S15-S15, ISSN: 0378-4274
Boobis A, 2012, Application of the MOA/human relevance framework to pesticide risk assessment, 48th Congress of the European-Societies-of-Toxicology (EUROTOX), Publisher: ELSEVIER IRELAND LTD, Pages: S28-S28, ISSN: 0378-4274
Andreoletti O, Budka H, Buncic S, et al., 2012, Scientific Opinion on the public health hazards to be covered by inspection of meat (poultry), EFSA Journal, Vol: 10
A qualitative risk assessment identified Campylobacter spp., Salmonella spp. and ESBL/AmpC gene-carrying bacteria as the most relevant biological hazards in the context of meat inspection of poultry. As none of these are detected by traditional visual meat inspection, establishing an integrated food safety assurance system, achievable through improved food chain information (FCI) and risk-based interventions, was proposed. This includes setting targets at carcass level and, when appropriate, flock level indicating what should be achieved for a given hazard. Elements of the system would be risk categorisation of flocks based on FCI and classification of abattoirs according to their capability to reduce carcass faecal contamination. It is proposed that post-mortem visual inspection is replaced by setting targets for the main hazards on the carcass, and by verification of the food business operator's hygiene management, using Process Hygiene Criteria. Chemical substances that might occur in poultry were ranked into four categories of potential concern based on pre-defined criteria. Dioxins, dioxin-like polychlorinated biphenyls, chloramphenicol, nitrofurans and nitroimidazoles were ranked as being of high potential concern. Chemical substances in poultry, however, are unlikely to pose an immediate or acute health risk for consumers. Sampling for chemical residues and contaminants should be based on the available FCI. Moreover, control programmes should be better integrated with feed controls and regularly updated to include new and emerging substances. Meat inspection is recognised as a valuable tool for surveillance and monitoring of specific animal health and welfare conditions. If visual post-mortem inspection is removed, other approaches should be applied to compensate for the associated loss of information on the occurrence of animal disease and welfare conditions. Extended use of FCI has the potential to compensate for some, but not all, of the information on ani
Andreoletti O, Budka H, Buncic S, et al., 2011, Scientific Opinion on the public health hazards to be covered by inspection of meat (swine), EFSA Journal, Vol: 9
A qualitative risk assessment identified Salmonella spp., Yersinia enterocolitica, Toxoplasma gondii and Trichinella spp. as the most relevant biological hazards in the context of meat inspection of swine. A comprehensive pork carcass safety assurance is the only way to ensure their effective control. This requires setting targets to be achieved in/on chilled carcasses, which also informs what has to be achieved earlier in the food chain. Improved Food Chain Information (FCI) enables risk-differentiation of pig batches (hazard-related) and abattoirs (process hygiene-related). Risk reduction measures at abattoir level are focused on prevention of microbial contamination through technology- and process hygiene-based measures (GMP/GHP- and HACCP-based), including omitting palpation/incision during post-mortem inspection in routine slaughter, as well as hazard reduction/inactivation meat treatments if necessary. At farm level, risk reduction measures are based on herd health programmes, closed breeding pyramids and GHP/GFP. Chemical substances listed in Council Directive 96/23/EC were ranked into four categories. Dioxins, dioxin-like polychlorinated biphenyls and chloramphenicol were ranked as being of high potential concern. However, chemical substances in pork are unlikely to pose an immediate or short term health risk for consumers. Opportunities for risk-based inspection strategies by means of differentiated sampling plans taking into account FCI were identified. Regular update of sampling programmes and inclusion of inspection criteria for the identification of illicit use of substances were also recommended. Meat inspection is a key component of the overall surveillance system for pig health and welfare but information is currently under-utilised. The changes proposed to the pig meat inspection system will lead to some reduction in the detection probability of diseases and welfare conditions. The difference is likely to be minimal for diseases/conditions that affe
Boobis A, 2011, Integrating miRNAs within current safety assessment: Future perspectives, 47th Congress of the European-Societies-of-Toxicology, Publisher: ELSEVIER IRELAND LTD, Pages: S31-S32, ISSN: 0378-4274
Flari V, Gosling JP, Hart A, et al., 2011, Eliciting expert knowledge about the form of the dose-response curve for genotoxic carcinogens at low exposures and the implications for a level of concern, 47th Congress of the European-Societies-of-Toxicology, Publisher: ELSEVIER IRELAND LTD, Pages: S260-S260, ISSN: 0378-4274
Koster S, Boobis A, Carlander D, et al., 2011, The application of the TTC concept to unknown substances found in the analysis of foods, 47th Congress of the European-Societies-of-Toxicology, Publisher: ELSEVIER IRELAND LTD, Pages: S28-S28, ISSN: 0378-4274
Boobis A, 2011, Risk assessment needs 21st century rationality as well as 21st century science, 47th Congress of the European-Societies-of-Toxicology, Publisher: ELSEVIER IRELAND LTD, Pages: S1-S1, ISSN: 0378-4274
Dorne JL, Doerge D, Boobis A, 2011, Mechanistic basis for the harmonisation of ecological and human risk assessment, 47th Congress of the European-Societies-of-Toxicology, Publisher: ELSEVIER IRELAND LTD, Pages: S9-S9, ISSN: 0378-4274
Koster S, Boobis AR, Cubberley R, et al., 2011, Application of the TTC concept to unknown substances found in analysis of foods, FOOD AND CHEMICAL TOXICOLOGY, Vol: 49, Pages: 1643-1660, ISSN: 0278-6915
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- Citations: 44
Felter SP, Conolly RB, Bercu JP, et al., 2011, A proposed framework for assessing risk from less-than-lifetime exposures to carcinogens, CRITICAL REVIEWS IN TOXICOLOGY, Vol: 41, Pages: 507-544, ISSN: 1040-8444
Quantitative methods for estimation of cancer risk have been developed for daily, lifetime human exposures. There are a variety of studies or methodologies available to address less-than-lifetime exposures. However, a common framework for evaluating risk from less-than-lifetime exposures (including short-term and/or intermittent exposures) does not exist, which could result in inconsistencies in risk assessment practice. To address this risk assessment need, a committee of the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute conducted a multisector workshop in late 2009 to discuss available literature, different methodologies, and a proposed framework. The proposed framework provides a decision tree and guidance for cancer risk assessments for less-than-lifetime exposures based on current knowledge of mode of action and dose-response. Available data from rodent studies and epidemiological studies involving less-than-lifetime exposures are considered, in addition to statistical approaches described in the literature for evaluating the impact of changing the dose rate and exposure duration for exposure to carcinogens. The decision tree also provides for scenarios in which an assumption of potential carcinogenicity is appropriate (e.g., based on structural alerts or genotoxicity data), but bioassay or other data are lacking from which a chemical-specific cancer potency can be determined. This paper presents an overview of the rationale for the workshop, reviews historical background, describes the proposed framework for assessing less-than-lifetime exposures to potential human carcinogens, and suggests next steps.
Felter SP, Conolly RB, Bercu JP, et al., 2011, A proposed framework for assessing risk from less-than-lifetime exposures to carcinogens., Crit Rev Toxicol, Vol: 41, Pages: 507-544
Quantitative methods for estimation of cancer risk have been developed for daily, lifetime human exposures. There are a variety of studies or methodologies available to address less-than-lifetime exposures. However, a common framework for evaluating risk from less-than-lifetime exposures (including short-term and/or intermittent exposures) does not exist, which could result in inconsistencies in risk assessment practice. To address this risk assessment need, a committee of the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute conducted a multisector workshop in late 2009 to discuss available literature, different methodologies, and a proposed framework. The proposed framework provides a decision tree and guidance for cancer risk assessments for less-than-lifetime exposures based on current knowledge of mode of action and dose-response. Available data from rodent studies and epidemiological studies involving less-than-lifetime exposures are considered, in addition to statistical approaches described in the literature for evaluating the impact of changing the dose rate and exposure duration for exposure to carcinogens. The decision tree also provides for scenarios in which an assumption of potential carcinogenicity is appropriate (e.g., based on structural alerts or genotoxicity data), but bioassay or other data are lacking from which a chemical-specific cancer potency can be determined. This paper presents an overview of the rationale for the workshop, reviews historical background, describes the proposed framework for assessing less-than-lifetime exposures to potential human carcinogens, and suggests next steps.
Adler S, Basketter D, Creton S, et al., 2011, Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010, ARCHIVES OF TOXICOLOGY, Vol: 85, Pages: 367-485, ISSN: 0340-5761
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- Citations: 388
Boobis A, Budinsky R, Collie S, et al., 2011, Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessment., Crit Rev Toxicol., Vol: 41, Pages: 369-383
Meek ME, Boobis AR, Crofton KM, et al., 2011, Risk assessment of combined exposure to multiple chemicals: A WHO/IPCS framework., Regul Toxicol Pharmacol
This paper describes a framework for the risk assessment of combined exposure to multiple chemicals based on and developed subsequent to the World Health Organization/International Programme on Chemical Safety Workshop on Aggregate/Cumulative Risk Assessment (Combined Exposures to Multiple Chemicals) held in 2007. The framework is designed to aid risk assessors in identifying priorities for risk management for a wide range of applications where co-exposures to multiple chemicals are expected. It is based on a hierarchical (phased) approach that involves integrated and iterative consideration of exposure and hazard at all phases, with each tier being more refined (i.e., less cautious and more certain) than the previous one, but more labor and data intensive. It includes reference to predictive and probabilistic methodology in various tiers in addition to tiered consideration of uncertainty. The paper also annexes two case studies that have been developed to test and refine the framework.
Park BK, Boobis A, Clarke S, et al., 2011, Managing the challenge of chemically reactive metabolites in drug development, NATURE REVIEWS DRUG DISCOVERY, Vol: 10, Pages: 292-306, ISSN: 1474-1776
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- Citations: 341
Carmichael N, Bausen M, Boobis AR, et al., 2011, Using mode of action information to improve regulatory decision-making: An ECETOC/ILSI RF/HESI workshop overview, CRITICAL REVIEWS IN TOXICOLOGY, Vol: 41, Pages: 175-186, ISSN: 1040-8444
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- Citations: 42
Dorne J-LCM, Kass GEN, Bordajandi LR, et al., 2011, Human Risk Assessment of Heavy Metals: Principles and Applications, METAL IONS IN TOXICOLOGY: EFFECTS, INTERACTIONS, INTERDEPENDENCIES, Vol: 8, Pages: 27-60, ISSN: 1559-0836
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- Citations: 81
McGregor D, Boobis A, Binaglia M, et al., 2010, Guidance for the classification of carcinogens under the globally harmonised system of classification and labelling of chemicals (GHS) (vol 40, pg 245, 2010), CRITICAL REVIEWS IN TOXICOLOGY, Vol: 40, Pages: 758-758, ISSN: 1040-8444
Boobis A, 2010, Exploration of the use of the threshold of toxicological concern and consideration of synergy for combined exposures (SY28-4), TOXICOLOGY LETTERS, Vol: 196, Pages: S35-S35, ISSN: 0378-4274
Hoekstra J, Hart A, Boobis A, et al., 2010, BRAFO tiered approach for benefit-risk assessment of foods., Food Chem Toxicol
Boobis AR, 2010, Food and Chemical Toxicology publishes papers that further scientific understanding of issues of public concern., Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol: 48
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- Citations: 1
McGregor D, Boobis A, Binaglia M, et al., 2010, Guidance for the classification of carcinogens under the Globally Harmonised System of Classification and Labelling of Chemicals (GHS), Crit Rev Toxicol, Vol: 40, Pages: 245-285
Boobis AR, 2010, Proceedings of the Final Congress of COST Action B25: Physiologically Based Pharmaco-Toxicokinetics and Dynamics, held in Athens, 26-27 May 2009, BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, Vol: 106, Pages: 145-145, ISSN: 1742-7835
Boobis AR, 2010, Mode of Action Considerations in the Quantitative Assessment of Tumour Responses in the Liver, BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, Vol: 106, Pages: 173-179, ISSN: 1742-7835
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- Citations: 10
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