Imperial College London
Alternate

Professor Alan Boobis OBE

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor of Toxicology
 
 
 
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Contact

 

a.boobis Website

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kramer:2019:10.1007/s00204-019-02501-x,
author = {Kramer, NI and Hoffmans, Y and Wu, S and Thiel, A and Thatcher, N and Allen, TEH and Levorato, S and Traussnig, H and Schulte, S and Boobis, A and Rietjens, IMCM and Vinken, M},
doi = {10.1007/s00204-019-02501-x},
journal = {ARCHIVES OF TOXICOLOGY},
pages = {2115--2125},
title = {Characterizing the coverage of critical effects relevant in the safety evaluation of food additives by AOPs},
url = {http://dx.doi.org/10.1007/s00204-019-02501-x},
volume = {93},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - There is considerable interest in adverse outcome pathways (AOPs) as a means of organizing biological and toxicological information to assist in data interpretation and method development. While several chemical sectors have shown considerable progress in applying this approach, this has not been the case in the food sector. In the present study, safety evaluation reports of food additives listed in Annex II of Regulation (EC) No 1333/2008 of the European Union were screened to qualitatively and quantitatively characterize toxicity induced in laboratory animals. The resulting database was used to identify the critical adverse effects used for risk assessment and to investigate whether food additives share common AOPs. Analysis of the database revealed that often such scrutiny of AOPs was not possible or necessary. For 69% of the food additives, the report did not document any adverse effects in studies based on which the safety evaluation was performed. For the remaining 31% of the 326 investigated food additives, critical adverse effects and related points of departure for establishing health-based guidance values could be identified. These mainly involved effects on the liver, kidney, cardiovascular system, lymphatic system, central nervous system and reproductive system. AOPs are available for many of these apical endpoints, albeit to different degrees of maturity. For other adverse outcomes pertinent to food additives, including gastrointestinal irritation and corrosion, AOPs are lacking. Efforts should focus on developing AOPs for these particular endpoints.
AU  - Kramer,NI
AU  - Hoffmans,Y
AU  - Wu,S
AU  - Thiel,A
AU  - Thatcher,N
AU  - Allen,TEH
AU  - Levorato,S
AU  - Traussnig,H
AU  - Schulte,S
AU  - Boobis,A
AU  - Rietjens,IMCM
AU  - Vinken,M
DO  - 10.1007/s00204-019-02501-x
EP  - 2125
PY  - 2019///
SN  - 0340-5761
SP  - 2115
TI  - Characterizing the coverage of critical effects relevant in the safety evaluation of food additives by AOPs
T2  - ARCHIVES OF TOXICOLOGY
UR  - http://dx.doi.org/10.1007/s00204-019-02501-x
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000483690200002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://link.springer.com/article/10.1007%2Fs00204-019-02501-x
UR  - http://hdl.handle.net/10044/1/73767
VL  - 93
ER  -
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