Imperial College London
Alternate

Professor Alan Boobis OBE

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor of Toxicology
 
 
 
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Contact

 

a.boobis Website

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Autrup:2020:10.1016/j.comtox.2020.100124,
author = {Autrup, H and Barile, FA and Colin, Berry S and Blaauboer, BJ and Boobis, A and Bolt, H and Borgert, CJ and Dekant, W and Dietrich, D and Domingo, JL and Batta, Gori G and Greim, H and Hengstler, J and Kacew, S and Marquardt, H and Pelkonen, O and Savolainen, K and Heslop-Harrison, P and Vermeulen, NP},
doi = {10.1016/j.comtox.2020.100124},
journal = {Computational Toxicology},
title = {Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?},
url = {http://dx.doi.org/10.1016/j.comtox.2020.100124},
volume = {14},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Theoretically, both synthetic endocrine disrupting chemicals (S-EDCs) and natural (exogenous and endogenous) endocrine disrupting chemicals (N-EDCs) can interact with endocrine receptors and disturb hormonal balance. However, compared to endogenous hormones, S-EDCs are only weak partial agonists with receptor affinities several orders of magnitude lower than S-EDCs. Thus, to elicit observable effects, S-EDCs require considerably higher concentrations to attain sufficient receptor occupancy or to displace natural hormones and other endogenous ligands. Significant exposures to exogenous N-EDCs may result from ingestion of foods such as soy-based diets, green tea and sweet mustard. While their potencies are lower as compared to natural endogenous hormones, they usually are considerably more potent than S-EDCs. Effects of exogenous N-EDCs on the endocrine system were observed at high dietary intakes. A causal relation between their mechanism of action and these effects is established and biologically plausible. In contrast, the assumption that the much lower human exposures to S-EDCs may induce observable endocrine effects is not plausible. Hence, it is not surprising that epidemiological studies searching for an association between S-EDC exposure and health effects have failed. Regarding testing for potential endocrine effects, a scientifically justified screen should use in vitro tests to compare potencies of S-EDCs with those of reference N-EDCs. When the potency of the S-EDC is similar or smaller than that of the N-EDC, further testing in laboratory animals and regulatory consequences are not warranted.
AU  - Autrup,H
AU  - Barile,FA
AU  - Colin,Berry S
AU  - Blaauboer,BJ
AU  - Boobis,A
AU  - Bolt,H
AU  - Borgert,CJ
AU  - Dekant,W
AU  - Dietrich,D
AU  - Domingo,JL
AU  - Batta,Gori G
AU  - Greim,H
AU  - Hengstler,J
AU  - Kacew,S
AU  - Marquardt,H
AU  - Pelkonen,O
AU  - Savolainen,K
AU  - Heslop-Harrison,P
AU  - Vermeulen,NP
DO  - 10.1016/j.comtox.2020.100124
PY  - 2020///
SN  - 2468-1113
TI  - Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?
T2  - Computational Toxicology
UR  - http://dx.doi.org/10.1016/j.comtox.2020.100124
VL  - 14
ER  -
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