Imperial College London
Alternate

ProfessorAdolfoBronstein

Faculty of Medicine, Department of Brain Sciences

Emeritus Clinical Professor Head of Neuro-otology Unit
 
 
 
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Contact

 

+44 (0)20 3313 5525a.bronstein

 
 
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Assistant

 

Miss Lorna Stevenson +44 (0)20 3313 5525

 
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Location

 

10 L15bLab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Anastasopoulos:2019:10.1152/jn.00343.2019,
author = {Anastasopoulos, D and Ziavra, N and Bronstein, A},
doi = {10.1152/jn.00343.2019},
journal = {Journal of Neurophysiology},
pages = {1928--1936},
title = {Large gaze shift generation whilst standing up - the role of the vestibular system},
url = {http://dx.doi.org/10.1152/jn.00343.2019},
volume = {122},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The functional significance of vestibular information for the generation of gaze shifts is controversial and less well established than the vestibular contribution to gaze stability. Here, we asked seven bilaterally avestibular patients to execute voluntary, whole-body pivot turns to visual targets up to 180° whilst standing. In these conditions not only the demands imposed on gaze transfer mechanisms are more challenging but also neck-proprioceptive input represents an inadequate source of head-in-space motion information. Patients' body segments motion was slower and jerky. In the absence of visual feedback, gaze advanced in small steps, closely resembling normal multiple-step gaze shift patterns but, as a consequence of the slow head motion, target acquisition was delayed. In approximately 25% of trials, however, patients moved faster but the velocity of prematurely emerging slow-phase compensatory eye movements remained lower than head-in-space velocity due to vestibulo-ocular failure. During these trials, therefore, gaze advanced towards the target without interruption but taking again longer than when normal controls use single-step gaze transfers. That is, even when patients attempted faster gaze shifts, exposing themselves to gaze instability they acquired distant targets significantly later than controls. Thus, whilst upright, loss of vestibular information not only disrupts gaze stability but also gaze transfers. The slow and ataxic head and trunk movements introduce significant foveation delays. These deficits explain patients' symptoms during upright activities and show, for the first time, the clinical significance of losing the so called "anti-compensatory" (gaze shifting) function of the vestibulo-ocular reflex.
AU  - Anastasopoulos,D
AU  - Ziavra,N
AU  - Bronstein,A
DO  - 10.1152/jn.00343.2019
EP  - 1936
PY  - 2019///
SN  - 0022-3077
SP  - 1928
TI  - Large gaze shift generation whilst standing up - the role of the vestibular system
T2  - Journal of Neurophysiology
UR  - http://dx.doi.org/10.1152/jn.00343.2019
UR  - http://hdl.handle.net/10044/1/73502
VL  - 122
ER  -
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