Imperial College London
Alternate

ProfessorAdolfoBronstein

Faculty of Medicine, Department of Brain Sciences

Emeritus Clinical Professor Head of Neuro-otology Unit
 
 
 
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Contact

 

+44 (0)20 3313 5525a.bronstein

 
 
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Assistant

 

Miss Lorna Stevenson +44 (0)20 3313 5525

 
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Location

 

10 L15bLab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ibitoye:2021:10.1016/j.clinph.2021.07.027,
author = {Ibitoye, RT and Desowska, A and Guven, O and Arshad, Q and Kaski, D and Bronstein, AM},
doi = {10.1016/j.clinph.2021.07.027},
journal = {Clinical Neurophysiology},
pages = {2751--2762},
title = {Small vessel disease disrupts EEG postural brain networks in ‘unexplained dizziness in the elderly’},
url = {http://dx.doi.org/10.1016/j.clinph.2021.07.027},
volume = {132},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectiveTo examine the hypothesis that small vessel disease disrupts postural networks in older adults with unexplained dizziness in the elderly (UDE).MethodsSimultaneous electroencephalography and postural sway measurements were undertaken in upright, eyes closed standing, and sitting postures (as baseline) in 19 younger adults, 33 older controls and 36 older patients with UDE. Older adults underwent magnetic resonance imaging to determine whole brain white matter hyperintensity volumes, a measure of small vessel disease. Linear regression was used to estimate the effect of instability on electroencephalographic power and connectivity.ResultsAgeing increased theta and alpha desynchronisation on standing. In older controls, delta and gamma power increased, and theta and alpha power reduced with instability. Dizzy older patients had higher white matter hyperintensity volumes and more theta desynchronisation during periods of instability. White matter hyperintensity volume and delta power during periods of instability were correlated, positively in controls but negatively in dizzy older patients. Delta power correlated with subjective dizziness and instability.ConclusionsNeural resource demands of postural control increase with age, particularly in patients with UDE, driven by small vessel disease.SignificanceEEG correlates of postural control saturate in older adults with UDE, offering a basis to this common syndrome.
AU  - Ibitoye,RT
AU  - Desowska,A
AU  - Guven,O
AU  - Arshad,Q
AU  - Kaski,D
AU  - Bronstein,AM
DO  - 10.1016/j.clinph.2021.07.027
EP  - 2762
PY  - 2021///
SN  - 1388-2457
SP  - 2751
TI  - Small vessel disease disrupts EEG postural brain networks in ‘unexplained dizziness in the elderly’
T2  - Clinical Neurophysiology
UR  - http://dx.doi.org/10.1016/j.clinph.2021.07.027
UR  - https://www.sciencedirect.com/science/article/pii/S1388245721007069?via%3Dihub
UR  - http://hdl.handle.net/10044/1/91640
VL  - 132
ER  -
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