Professor Angela Brueggemann

Faculty of Medicine, Department of Medicine

Visiting Professor

Contact

Location

Commonwealth BuildingHammersmith Campus

Summary

The main research focus of the Brueggemann group is Streptococcus pneumoniae (the ‘pneumococcus’), a bacterium that is a major cause of diseases such as pneumonia and meningitis worldwide. Current research involves using high-throughput genotyping and whole genome sequencing techniques and unique collections of isolates to understand pneumococcal evolution, especially evolutionary changes related to antimicrobial and vaccine selective pressures. Molecular epidemiology and population biology provide the foundation for all aspects of the group’s research.

Our work has particular relevance to: i) understanding how antimicrobial resistance determinants evolve and spread; ii) long-term effectiveness of the existing pneumococcal conjugate vaccines; iii) the design of future vaccines; and iv) the development of novel antimicrobials.

Our work takes place at the University of Oxford: https://www.ndph.ox.ac.uk/team/angela-brueggemann

Publications

Journals

Quirk SJ, Haraldsson G, Hjálmarsdóttir MÁ, et al.Quirk SJ, Haraldsson G, Hjálmarsdóttir MÁ, van Tonder AJ, Hrafnkelsson B, Bentley SD, Haraldsson Á, Erlendsdóttir H, Brueggemann AB, Kristinsson KG close, 2019, Vaccination of Icelandic children with the 10-valent pneumococcal vaccine leads to a significant herd effect among adults in Iceland, Journal of Clinical Microbiology, Vol:57, ISSN:0095-1137

van Tonder AJ, Bray JE, Jolley KA, et al.van Tonder AJ, Bray JE, Jolley KA, van Rensburg MJ, Quirk SJ, Haraldsson G, Maidens MCJ, Bentley SD, Haraldsson A, Erlendsdottir H, Kristinsson KG, Brueggemann AB close, 2019, Genomic analyses of >3,100 nasopharyngeal pneumococci revealed significant differences between pneumococci recovered in four different geographical regions, Frontiers in Microbiology, Vol:10, ISSN:1664-302X

Quirk SJ, Haraldsson G, Erlendsdottir H, et al.Quirk SJ, Haraldsson G, Erlendsdottir H, Hjalmarsdottir MA, van Tonder AJ, Hrafnkelsson B, Sigurdsson S, Bentley SD, Haraldsson A, Brueggemann AB, Kristinsson KG close, 2018, Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland, Journal of Clinical Microbiology, Vol:56, ISSN:0095-1137

Javan RR, van Tonder AJ, King JP, et al.Javan RR, van Tonder AJ, King JP, Harrold CL, Brueggemann AB close, 2018, Genome Sequencing Reveals a Large and Diverse Repertoire of Antimicrobial Peptides, Frontiers in Microbiology, Vol:9, ISSN:1664-302X

Kurioka A, van Wilgenburg B, Javan RR, et al.Kurioka A, van Wilgenburg B, Javan RR, Hoyle R, van Tonder AJ, Harrold CL, Leng T, Howson LJ, Shepherd D, Cerundolo V, Brueggemann AB, Klenerman P close, 2018, Diverse Streptococcus pneumoniae strains drive a MAIT cell response through MR1-dependent and cytokine-driven pathways, Journal of Infectious Diseases, Vol:217, ISSN:0022-1899, Pages:988-999

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