Summary
The main research focus of the Brueggemann group is Streptococcus pneumoniae (the ‘pneumococcus’), a bacterium that is a major cause of diseases such as pneumonia and meningitis worldwide. Current research involves using high-throughput genotyping and whole genome sequencing techniques and unique collections of isolates to understand pneumococcal evolution, especially evolutionary changes related to antimicrobial and vaccine selective pressures. Molecular epidemiology and population biology provide the foundation for all aspects of the group’s research.
Our work has particular relevance to: i) understanding how antimicrobial resistance determinants evolve and spread; ii) long-term effectiveness of the existing pneumococcal conjugate vaccines; iii) the design of future vaccines; and iv) the development of novel antimicrobials.
Our work takes place at the University of Oxford: https://www.ndph.ox.ac.uk/team/angela-brueggemann
Publications
Journals
Brueggemann AB, Jansen van Rensburg MJ, Shaw D, et al.Brueggemann AB, Jansen van Rensburg MJ, Shaw D, McCarthy ND, Jolley KA, Maiden MCJ, van der Linden MPG, Amin-Chowdhury Z, Bennett DE, Borrow R, Brandileone M-CC, Broughton K, Campbell R, Cao B, Casanova C, Choi EH, Chu YW, Clark SA, Claus H, Coelho J, Corcoran M, Cottrell S, Cunney RJ, Dalby T, Davies H, de Gouveia L, Deghmane A-E, Demczuk W, Desmet S, Drew RJ, du Plessis M, Erlendsdottir H, Fry NK, Fuursted K, Gray SJ, Henriques-Normark B, Hale T, Hilty M, Hoffmann S, Humphreys H, Ip M, Jacobsson S, Johnston J, Kozakova J, Kristinsson KG, Krizova P, Kuch A, Ladhani SN, Lâm T-T, Lebedova V, Lindholm L, Litt DJ, Martin I, Martiny D, Mattheus W, McElligott M, Meehan M, Meiring S, Mölling P, Morfeldt E, Morgan J, Mulhall RM, Muñoz-Almagro C, Murdoch DR, Murphy J, Musilek M, Mzabi A, Perez-Argüello A, Perrin M, Perry M, Redin A, Roberts R, Roberts M, Rokney A, Ron M, Scott KJ, Sheppard CL, Siira L, Skoczyńska A, Sloan M, Slotved H-C, Smith AJ, Song JY, Taha M-K, Toropainen M, Tsang D, Vainio A, van Sorge NM, Varon E, Vlach J, Vogel U, Vohrnova S, von Gottberg A, Zanella RC, Zhou F close, 2021, Changes in the incidence of invasive disease due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and territories in the Invasive Respiratory Infection Surveillance Initiative: a prospective analysis of surveillance data, The Lancet Digital Health, Vol:3, ISSN:2589-7500, Pages:e360-e370
Diallo K, Feteh VF, Ibe L, et al.Diallo K, Feteh VF, Ibe L, Antonio M, Caugant DA, du Plessis M, Deghmane A-E, Feavers IM, Fernandez K, Fox LM, Rodrigues CMC, Ronveaux O, Taha M-K, Wang X, Brueggemann AB, Maiden MCJ, Harrison OB close, 2021, Molecular diagnostic assays for the detection of common bacterial meningitis pathogens: a narrative review, Ebiomedicine, Vol:65, ISSN:2352-3964
Rodgers E, Bentley SD, Borrow R, et al.Rodgers E, Bentley SD, Borrow R, Bratcher HB, Brisse S, Brueggemann AB, Caugant DA, Findlow J, Fox L, Glennie L, Harrison LH, Harrison OB, Heyderman RS, van Rensburg MJ, Jolley KA, Kwambana-Adams B, Ladhani S, LaForce M, Levin M, Lucidarme J, MacAlasdair N, Maclennan J, Maiden MCJ, Maynard-Smith L, Muzzi A, Oster P, Rodrigues CMC, Ronveaux O, Serino L, Smith V, van der Ende A, Vázquez J, Wang X, Yezli S, Stuart JM close, 2020, The global meningitis genome partnership., Journal of Infection, Vol:4, ISSN:0163-4453, Pages:510-520
Kwambana-Adams BA, Mulholland EK, Satzke C, et al.Kwambana-Adams BA, Mulholland EK, Satzke C, Smith-Vaughan H, Brueggemann A, Whitney C, Kirkham L-A, Sa-Leao R, Vidal J, Graham H, Murdoch D, Paranhos-Baccala G, Goldblatt D, Pomat WS, Best E, McIntyre P, McVernon J, Weinberger D, Dunne E, Scott JA, Cripps AW, Mackenzie G, Madhi S, Torzillo P, Graham S, Kartasasmita C, Awori JO, Smith A, Hilty M, Blyth C, Pilishvili T, Hammitt L, Andrews R, Crooks K, Hanage WP, Wijburg O, Morpeth S, French N, Cheng A, Trappetti C, Tuomanen E, Rosch J, Arora N, Rodgers G, Yoshida LM, Richmond P, Licciardi P, Ferreira DM close, 2020, State-of-the-art in the pneumococcal field: Proceedings of the 11(th) International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-11), Pneumonia, Vol:12, ISSN:2200-6133, Pages:1-14
Javan RR, Ramos-Sevillano E, Akter A, et al.Javan RR, Ramos-Sevillano E, Akter A, Brown J, Brueggemann AB close, 2019, Prophages and satellite prophages are widespread in Streptococcus and may play a role in pneumococcal pathogenesis, Nature Communications, Vol:10, ISSN:2041-1723
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