Imperial College London
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DrAnneBurke-Gaffney

Faculty of Medicine, National Heart & Lung Institute

Lecturer
 
 
 
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Contact

 

a.burke-gaffney

 
 
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Location

 

GSB 311Royal BromptonRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mohiaddin:2018:10.1007/s40119-018-0121-2,
author = {Mohiaddin, H and Wong, TDFK and Burke-Gaffney, A and Bogle, RG},
doi = {10.1007/s40119-018-0121-2},
journal = {Cardiology and Therapy},
pages = {127--149},
title = {Drug-coated balloon-only percutaneous coronary intervention for the treatment of De novo coronary artery disease: a systematic review},
url = {http://dx.doi.org/10.1007/s40119-018-0121-2},
volume = {7},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Percutaneous coronary intervention (PCI) with a drug coated balloon (DCB) is a novel treatment which seeks to acutely dilate a coronary stenosis and deliver an anti-proliferative drug to the vessel wall (reducing the risk of re-stenosis), without implanting a drug eluting stent (DES). In this study, we performed a systematic review of stentless DCB-only angioplasty in de novo coronary artery disease. We identified 41 studies examining the effects of DCB-only PCI in a variety of clinical scenarios including small vessels, bifurcations, calcified lesions, and primary PCI. DCB-only PCI appears to be associated with comparable clinical outcomes to DESs and superior angiographic outcomes to plain-old balloon angioplasty. Although current data are promising, there is still a need for further long-term randomized control trial data comparing a DCB-only approach specifically against a second- or third-generation DES. A 4-week period of dual antiplatelet therapy provides a real advantage for the DCB-only PCI approach, which is not possible with most DESs. Since rates of adverse clinical outcomes are very low for all PCI procedures attention should be turned to the development of robust endpoints with which to compare DCB-only PCI approaches to the standard treatment with a DES.
AU  - Mohiaddin,H
AU  - Wong,TDFK
AU  - Burke-Gaffney,A
AU  - Bogle,RG
DO  - 10.1007/s40119-018-0121-2
EP  - 149
PY  - 2018///
SN  - 2193-6544
SP  - 127
TI  - Drug-coated balloon-only percutaneous coronary intervention for the treatment of De novo coronary artery disease: a systematic review
T2  - Cardiology and Therapy
UR  - http://dx.doi.org/10.1007/s40119-018-0121-2
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30368735
UR  - http://hdl.handle.net/10044/1/64271
VL  - 7
ER  -
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