Imperial College London
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ProfessorAndrewBush

Faculty of Medicine, National Heart & Lung Institute

Professor of Paediatric Respirology
 
 
 
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Contact

 

+44 (0)20 7352 8121 ext 2255a.bush

 
 
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Location

 

Chelsea WingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jolliffe:2020:10.1164/rccm.201909-1867OC,
author = {Jolliffe, DA and Stefanidis, C and Wang, Z and Kermani, NZ and Dimitrov, V and White, JH and McDonough, JE and Janssens, W and Pfeffer, P and Griffiths, CJ and Bush, A and Guo, Y and Christenson, S and Adcock, IM and Chung, KF and Thummel, KE and Martineau, AR},
doi = {10.1164/rccm.201909-1867OC},
journal = {American Journal of Respiratory and Critical Care Medicine},
pages = {371--382},
title = {Vitamin D metabolism is dysregulated in asthma and chronic obstructive pulmonary disease.},
url = {http://dx.doi.org/10.1164/rccm.201909-1867OC},
volume = {202},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - RATIONALE: Vitamin D deficiency is common in patients with asthma and COPD. Low 25-hydroxyvitamin D (25[OH]D) levels may represent a cause or a consequence of these conditions. OBJECTIVE: To determine whether vitamin D metabolism is altered in asthma or COPD. METHODS: We conducted a longitudinal study in 186 adults to determine whether the 25(OH)D response to six oral doses of 3 mg vitamin D3, administered over one year, differed between those with asthma or COPD vs. controls. Serum concentrations of vitamin D3, 25(OH)D3 and 1α,25-dihydroxyvitamin D3 (1α,25[OH]2D3) were determined pre- and post-supplementation in 93 adults with asthma, COPD or neither condition, and metabolite-to-parent compound molar ratios were compared between groups to estimate hydroxylase activity. Additionally, we analyzed fourteen datasets to compare expression of 1α,25[OH]2D3-inducible gene expression signatures in clinical samples taken from adults with asthma or COPD vs. controls. MEASUREMENTS AND MAIN RESULTS: The mean post-supplementation 25(OH)D increase in participants with asthma (20.9 nmol/L) and COPD (21.5 nmol/L) was lower than in controls (39.8 nmol/L; P=0.001). Compared with controls, patients with asthma and COPD had lower molar ratios of 25(OH)D3-to-vitamin D3 and higher molar ratios of 1α,25(OH)2D3-to-25(OH)D3 both pre- and post-supplementation (P≤0.005). Inter-group differences in 1α,25[OH]2D3-inducible gene expression signatures were modest and variable where statistically significant. CONCLUSIONS: Attenuation of the 25(OH)D response to vitamin D supplementation in asthma and COPD associated with reduced molar ratios of 25(OH)D3-to-vitamin D3 and increased molar ratios of 1α,25(OH)2D3-to-25(OH)D3 in serum, suggesting that vitamin D metabolism is dysregulated in these conditions.
AU  - Jolliffe,DA
AU  - Stefanidis,C
AU  - Wang,Z
AU  - Kermani,NZ
AU  - Dimitrov,V
AU  - White,JH
AU  - McDonough,JE
AU  - Janssens,W
AU  - Pfeffer,P
AU  - Griffiths,CJ
AU  - Bush,A
AU  - Guo,Y
AU  - Christenson,S
AU  - Adcock,IM
AU  - Chung,KF
AU  - Thummel,KE
AU  - Martineau,AR
DO  - 10.1164/rccm.201909-1867OC
EP  - 382
PY  - 2020///
SN  - 1073-449X
SP  - 371
TI  - Vitamin D metabolism is dysregulated in asthma and chronic obstructive pulmonary disease.
T2  - American Journal of Respiratory and Critical Care Medicine
UR  - http://dx.doi.org/10.1164/rccm.201909-1867OC
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32186892
UR  - https://www.atsjournals.org/doi/10.1164/rccm.201909-1867OC
UR  - http://hdl.handle.net/10044/1/84755
VL  - 202
ER  -
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