Publications

BibTex format

@article{Haider:2022:10.1164/rccm.202110-2418OC,
author = {Haider, S and Fontanella, S and Ullah, A and Turner, S and Simpson, A and Roberts, G and Murray, CS and Holloway, JW and Curtin, JA and Cullinan, P and Arshad, SH and Hurault, G and Granell, R and Custovic, A and STELARUNICORN11, investigators},
doi = {10.1164/rccm.202110-2418OC},
journal = {American Journal of Respiratory and Critical Care Medicine},
pages = {950--960},
title = {Evolution of eczema, wheeze and rhinitis from infancy to early adulthood: four birth cohort studies},
url = {http://dx.doi.org/10.1164/rccm.202110-2418OC},
volume = {206},
year = {2022}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: The relationship between eczema, wheeze/asthma and rhinitis is complex, and epidemiology and mechanisms of their comorbidities is unclear. OBJECTIVE: To investigate within-individual patterns of morbidity of eczema, wheeze and rhinitis from birth to adolescence/early adulthood. METHODS: We investigated onset/progression/resolution of eczema, wheeze and rhinitis using descriptive statistics, sequence mining and Latent Markov modelling (LMM) in four population-based birth cohorts. We used logistic regression to ascertain if early-life eczema or wheeze, or genetic factors (filaggrin mutations and 17q21 variants), increase the risk of multimorbidity. RESULTS: Single conditions, although the most prevalent, were observed significantly less frequently than by chance. There was considerable variation in the timing of onset/remission/persistence/intermittence. Multimorbidity of eczema+wheeze+rhinitis was rare, but significantly over-represented (3-6 times more often than by chance). Although infantile eczema was associated with subsequent multimorbidity, most children with eczema (75.4%) did not progress to any multimorbidity pattern. FLG mutations and rs7216389 were not associated with persistence of eczema/wheeze as single conditions, but both increased the risk of multimorbidity (FLG by 2-3-fold, rs7216389 risk variant by 1.4-1.7-fold). LMM revealed 5 latent states (No disease/low risk; Mainly eczema; Mainly Wheeze; Mainly rhinitis; Multimorbidity). The most likely transition to Multimorbidity was from Eczema state (0.21). However, although this was one of the highest transition probabilities, only 1/5 of those with eczema transitioned to multimorbidity. CONCLUSIONS: Atopic diseases fit a multimorbidity framework, with no evidence for sequential "atopic march" progression. The highest transition to multimorbidity was from eczema, but most children with eczema (>three quarters) had no comorbidities.
AU  - Haider,S
AU  - Fontanella,S
AU  - Ullah,A
AU  - Turner,S
AU  - Simpson,A
AU  - Roberts,G
AU  - Murray,CS
AU  - Holloway,JW
AU  - Curtin,JA
AU  - Cullinan,P
AU  - Arshad,SH
AU  - Hurault,G
AU  - Granell,R
AU  - Custovic,A
AU  - STELARUNICORN11,investigators
DO  - 10.1164/rccm.202110-2418OC
EP  - 960
PY  - 2022///
SN  - 1073-449X
SP  - 950
TI  - Evolution of eczema, wheeze and rhinitis from infancy to early adulthood: four birth cohort studies
T2  - American Journal of Respiratory and Critical Care Medicine
UR  - http://dx.doi.org/10.1164/rccm.202110-2418OC
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35679320
UR  - https://www.atsjournals.org/doi/10.1164/rccm.202110-2418OC
UR  - http://hdl.handle.net/10044/1/100041
VL  - 206
ER  -

Download

ProfessorAndrewBush

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)