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@article{Bousquet:2023:10.1111/all.15679,
author = {Bousquet, J and Melén, E and Haahtela, T and Koppelman, GH and Togias, A and Valenta, R and Akdis, CA and Czarlewski, W and Rothenberg, M and Valiulis, A and Wickman, M and Akdis, M and Aguilar, D and Bedbrook, A and Bindslev-Jensen, C and Bosnic-Anticevich, S and Boulet, LP and Brightling, CE and Brussino, L and Burte, E and Bustamante, M and Canonica, GW and Cecchi, L and Celedon, JC and Chaves, Loureiro C and Costa, E and Cruz, AA and Erhola, M and Gemicioglu, B and Fokkens, WJ and Garcia-Aymerich, J and Guerra, S and Heinrich, J and Ivancevich, JC and Keil, T and Klimek, L and Kuna, P and Kupczyk, M and Kvedariene, V and Larenas-Linnemann, DE and Lemonnier, N and Lodrup, Carlsen KC and Louis, R and Makela, M and Makris, M and Maurer, M and Momas, I and Morais-Almeida, M and Mullol, J and Naclerio, RN and Nadeau, K and Nadif, R and Niedoszytko, M and Okamoto, Y and Ollert, M and Papadopoulos, NG and Passalacqua, G and Patella, V and Pawankar, R and Pham-Thi, N and Pfaar, O and Regat},
doi = {10.1111/all.15679},
journal = {Allergy},
pages = {1169--1203},
title = {Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis},
url = {http://dx.doi.org/10.1111/all.15679},
volume = {78},
year = {2023}
}

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TY  - JOUR
AB  - Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the "Epithelial Barrier Hypothesis." This review determined that the "one-airway-one-disease" concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme "allergic" (asthma) phenotype combining asthma, rhinitis, and conjunctivitis. Rhinitis alone and rhinitis and asthma multimorbidity represent two distinct diseases with the following differences: (i) genomic and transcriptomic background (Toll-Like Receptors and IL-17 for rhinitis alone as a local disease; IL-33 and IL-5 for allergic and non-allergic multimorbidity as a systemic disease), (ii) allergen sensitization patterns (mono- or pauci-sensitization versus polysensitization), (iii) severity of symptoms, and (iv) treatment response. In conclusion, rhinitis alone (local disease) and rhinitis with asthma multimorbidity (systemic disease) should be considered as two distinct diseases, possibly modulated by the microbiome, and may be a model for understanding the epidemics of chronic and autoimmune diseases.
AU  - Bousquet,J
AU  - Melén,E
AU  - Haahtela,T
AU  - Koppelman,GH
AU  - Togias,A
AU  - Valenta,R
AU  - Akdis,CA
AU  - Czarlewski,W
AU  - Rothenberg,M
AU  - Valiulis,A
AU  - Wickman,M
AU  - Akdis,M
AU  - Aguilar,D
AU  - Bedbrook,A
AU  - Bindslev-Jensen,C
AU  - Bosnic-Anticevich,S
AU  - Boulet,LP
AU  - Brightling,CE
AU  - Brussino,L
AU  - Burte,E
AU  - Bustamante,M
AU  - Canonica,GW
AU  - Cecchi,L
AU  - Celedon,JC
AU  - Chaves,Loureiro C
AU  - Costa,E
AU  - Cruz,AA
AU  - Erhola,M
AU  - Gemicioglu,B
AU  - Fokkens,WJ
AU  - Garcia-Aymerich,J
AU  - Guerra,S
AU  - Heinrich,J
AU  - Ivancevich,JC
AU  - Keil,T
AU  - Klimek,L
AU  - Kuna,P
AU  - Kupczyk,M
AU  - Kvedariene,V
AU  - Larenas-Linnemann,DE
AU  - Lemonnier,N
AU  - Lodrup,Carlsen KC
AU  - Louis,R
AU  - Makela,M
AU  - Makris,M
AU  - Maurer,M
AU  - Momas,I
AU  - Morais-Almeida,M
AU  - Mullol,J
AU  - Naclerio,RN
AU  - Nadeau,K
AU  - Nadif,R
AU  - Niedoszytko,M
AU  - Okamoto,Y
AU  - Ollert,M
AU  - Papadopoulos,NG
AU  - Passalacqua,G
AU  - Patella,V
AU  - Pawankar,R
AU  - Pham-Thi,N
AU  - Pfaar,O
AU  - Regateiro,FS
AU  - Ring,J
AU  - Rouadi,PW
AU  - Samolinski,B
AU  - Sastre,J
AU  - Savouré,M
AU  - Scichilone,N
AU  - Shamji,MH
AU  - Sheikh,A
AU  - Siroux,V
AU  - Sousa-Pinto,B
AU  - Standl,M
AU  - Sunyer,J
AU  - Taborda-Barata,L
AU  - Toppila-Salmi,S
AU  - Torres,MJ
AU  - Tsiligianni,I
AU  - Valovirta,E
AU  - Vandenplas,O
AU  - Ventura,MT
AU  - Weiss,S
AU  - Yorgancioglu,A
AU  - Zhang,L
AU  - Abdul,Latiff AH
AU  - Aberer,W
AU  - Agache,I
AU  - Al-Ahmad,M
AU  - Alobid,I
AU  - Ansotegui,IJ
AU  - Arshad,SH
AU  - Asayag,E
AU  - Barbara,C
AU  - Baharudin,A
AU  - Battur,L
AU  - Bennoor,KS
AU  - Berghea,EC
AU  - Bergmann,KC
AU  - Bernstein,D
AU  - Bewick,M
AU  - Blain,H
AU  - Bonini,M
AU  - Braido,F
AU  - Buhl,R
AU  - Bumbacea,RS
AU  - Bush,A
AU  - Calderon,M
AU  - Calvo-Gil,M
AU  - Camargos,P
AU  - Caraballo,L
AU  - Cardona,V
AU  - Carr,W
AU  - Carreiro-Martins,P
AU  - Casale,T
AU  - Cepeda,Sarabia AM
AU  - Chandrasekharan,R
AU  - Charpin,D
AU  - Chen,YZ
AU  - Cherrez-Ojeda,I
AU  - Chivato,T
AU  - Chkhartishvili,E
AU  - Christoff,G
AU  - Chu,DK
AU  - Cingi,C
AU  - Correia,de Sousa J
AU  - Corrigan,C
AU  - Custovic,A
AU  - D'Amato,G
AU  - Del,Giacco S
AU  - De,Blay F
AU  - Devillier,P
AU  - Didier,A
AU  - do,Ceu Teixeira M
AU  - Dokic,D
AU  - Douagui,H
AU  - Doulaptsi,M
AU  - Durham,S
AU  - Dykewicz,M
AU  - Eiwegger,T
AU  - El-Sayed,ZA
AU  - Emuzyte,R
AU  - Fiocchi,A
AU  - Fyhrquist,N
AU  - Gomez,RM
AU  - Gotua,M
AU  - Guzman,MA
AU  - Hagemann,J
AU  - Hamamah,S
AU  - Halken,S
AU  - Halpin,DMG
AU  - Hofmann,M
AU  - Hossny,E
AU  - Hrubiko,M
AU  - Irani,C
AU  - Ispayeva,Z
AU  - Jares,E
AU  - Jartti,T
AU  - Jassem,E
AU  - Julge,K
AU  - Just,J
AU  - Jutel,M
AU  - Kaidashev,I
AU  - Kalayci,O
AU  - Kalyoncu,AF
AU  - Kardas,P
AU  - Kirenga,B
AU  - Kraxner,H
DO  - 10.1111/all.15679
EP  - 1203
PY  - 2023///
SN  - 0105-4538
SP  - 1169
TI  - Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis
T2  - Allergy
UR  - http://dx.doi.org/10.1111/all.15679
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36799120
UR  - https://onlinelibrary.wiley.com/doi/10.1111/all.15679
UR  - http://hdl.handle.net/10044/1/106126
VL  - 78
ER  -

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