Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Lecturer in Chronic Lung Disease







369Sir Alexander Fleming BuildingSouth Kensington Campus





I completed my undergraduate studies in Chemistry at University College Dublin in 2001 and subsequently undertook a PhD in medicinal chemistry within the group of Dr. John Walsh at the School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin in 2002. After a period in industry, I carried out postdoctoral work at Northwestern University, Chicago; this work focused on immune pathways involved in asthma, allergy and anaphylaxis. 

In 2011, I joined the laboratories of Prof. Irina Udalova at the University of Oxford and Prof. Clare Lloyd at Imperial College London, in a collaborative project funded by the American Asthma Society entitled “Does IRF5 control allergic airways disease?”. I was appointed as a Lecturer in Chronic Lung Disease at the Inflammation, Repair & Development Section, NHLI in 2016 and was awarded an Asthma UK senior fellowship in 2017. My work focuses on the role of alveolar macrophages in asthma and idiopathic pulmonary fibrosis. 



Velez TE, Byrne AJ, Wechsler JB, et al., 2019, Histamine-driven responses are sustained via a bioactive metabolite., J Allergy Clin Immunol

Saglani S, Gregory LG, Manghera AK, et al., 2018, Inception of early-life allergen-induced airway hyperresponsiveness is reliant on IL-13(+)CD4(+) T cells, Science Immunology, Vol:3, ISSN:2470-9468

Byrne AJ, Weiss M, Mathie SA, et al., 2017, A critical role for IRF5 in regulating allergic airway inflammation, Mucosal Immunology, Vol:10, ISSN:1933-0219, Pages:716-726

Byrne AJ, Maher TM, Lloyd CM, 2016, Pulmonary Macrophages: A New Therapeutic Pathway in Fibrosing Lung Disease?, Trends in Molecular Medicine, Vol:22, ISSN:1471-4914, Pages:303-316


Cook J, Martin-Alonso A, Sanghani N, et al., 2018, Children with Pre-School Wheeze Have Neutrophilic Airway Inflammation Associated with Bacteria and Viruses During Periods of Clinical Stability, International Conference of the American-Thoracic-Society, AMER THORACIC SOC, ISSN:1073-449X

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