I completed my undergraduate studies in Chemistry at University College Dublin and subsequently undertook a PhD in medicinal chemistry at the School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin. After a period in industry, I carried out postdoctoral work at Northwestern University, Chicago; this work focused on immune pathways involved in asthma, allergy and anaphylaxis.
In 2011, I joined the laboratories of Prof. Irina Udalova at the University of Oxford and Prof. Clare Lloyd at Imperial College London, in a collaborative project funded by the American Asthma Society entitled “Does IRF5 control allergic airways disease?”. I was appointed as a Lecturer in Chronic Lung Disease at the Inflammation, Repair & Development Section, NHLI in 2016 and was awarded a Joan Bending, Evelyn Bending, Mervyn Stephens Olive Stephens Memorial Fellowship fellowship in 2017. My work aims to understand the role of airway macrophages during chronic lung diseases such as asthma and idiopathic pulmonary fibrosis.
et al., 2021, DNA Methylome Alterations are Associated with Airway Macrophage Differentiation and Phenotype During Lung Fibrosis., Am J Respir Crit Care Med
et al., 2021, The respiratory microbiome in chronic hypersensitivity pneumonitis is distinct from that of idiopathic pulmonary fibrosis, American Journal of Respiratory and Critical Care Medicine, Vol:203, ISSN:1073-449X, Pages:339-347
et al., 2021, IRF5 regulates airway macrophage metabolic responses, Clinical and Experimental Immunology, Vol:204, ISSN:0009-9104, Pages:134-143
Ogger PP, Byrne AJ, 2020, Macrophage metabolic reprogramming during chronic lung disease, Mucosal Immunology, Vol:14, ISSN:1933-0219, Pages:282-295
et al., 2020, Itaconate controls the severity of pulmonary fibrosis, Science Immunology, Vol:5, ISSN:2470-9468, Pages:1-13