Overview
Grant support from the following agencies:
EPSRC, BBSRC, MRC, DTI-Smart, Wellcome Trust, Leverhulme Trust, CRUK
Collaborative support from the following companies:
AstraZeneca, GlaxoSmithKline, Novartis, Roche, Sanofi-Aventis, Pfizer, Syngenta, Bayer Cropscience, GE Healthcare, Avecia
- Total synthesis of bioactive natural products: anti-tumour Amaryllidaceae alkaloids, anti-HIV Celastraceae sesquiterpenoids and anti-asthma macrolides
- Development of asymmetric nucleophilic organocatalysts for acylation of alcohols and amines
- Development of organogermanium chemistry for use in novel parallel synthesis linkers
- Novel methods for supported-synthesis of isotopically labeled compounds for e.g. Positron Emission Tomography (PET)
- Development of antagonists to protein-protein interactions - IgE/high affinity receptor
- The interactions of thiols with nitric oxide - S-nitrosothiol and sulfenic acid chemistry
- Development of nuclear receptor protein regulators as potential anti-cancer therapeutic leads
Collaborators
Prof Brian Sutton, Kings College London, Randall Institute, Structural Biology of IgE
Prof Simak Ali, Surgery and Cancer, Imperial College London, Nuclear Receptor Biology
Prof Eric Aboagye, Surgery and Cancer, Imperial College London, PET Imaging
Dr Andrew Beavil, King's College London, Randall Institute, Structural Biology of IgE
Prof Robin Leatherbarrow, Chemistry, Imperial College London, Peptide and Protein Chemistry
Dr Nathan Davies, Institute of Hepatology, UCL, Oxidative Stress in Hepatic Disorders
Dr Greg Qunilan, The Brompton Hospital, IC, Oxidative Stress in Respiratory Critical Care
Research Staff
CARROLL,LAURENCE
PISANESCHI,FEDERICA
Research Student Supervision
ABAS,HOSSAY
EVANS,HELEN
GEORGE,GUILLAUME
HECKENAST,ZSOFIA
HOWELL,SUPINYA
JOURDAIN,ROXANE
MUELLER,MELANIE
MURRAY,JAMES
NIEH,LING-FU