Imperial College London

Professor Alan C Spivey

Faculty of Natural SciencesDepartment of Chemistry

Professor of Synthetic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 5841a.c.spivey Website CV

 
 
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Assistant

 

Miss Andrea Rialas +44 (0)20 7594 5414

 
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Location

 

501CMolecular Sciences Research HubWhite City Campus

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Summary

 

Overview

Grant support from the following agencies:

EPSRC, BBSRC, MRC, DTI-Smart, Wellcome Trust, Leverhulme Trust, CRUK

Collaborative support from the following companies:

AstraZeneca, GlaxoSmithKline, Novartis, Roche, Sanofi-Aventis, Pfizer, Syngenta, Bayer Cropscience, GE Healthcare, Avecia

  • Total synthesis of bioactive natural products: anti-tumour Amaryllidaceae alkaloids, anti-HIV Celastraceae sesquiterpenoids and anti-asthma macrolides
  • Development of asymmetric nucleophilic organocatalysts for acylation of alcohols and amines
  • Development of organogermanium chemistry for use in novel parallel synthesis linkers
  • Novel methods for supported-synthesis of isotopically labeled compounds for e.g. Positron Emission Tomography (PET)
  • Development of antagonists to protein-protein interactions - IgE/high affinity receptor
  • The interactions of thiols with nitric oxide - S-nitrosothiol and sulfenic acid chemistry
  • Development of nuclear receptor protein regulators as potential anti-cancer therapeutic leads

Collaborators

Prof Brian Sutton, Kings College London, Randall Institute, Structural Biology of IgE

Prof Simak Ali, Surgery and Cancer, Imperial College London, Nuclear Receptor Biology

Prof Eric Aboagye, Surgery and Cancer, Imperial College London, PET Imaging

Dr Andrew Beavil, King's College London, Randall Institute, Structural Biology of IgE

Prof Robin Leatherbarrow, Chemistry, Imperial College London, Peptide and Protein Chemistry

Dr Nathan Davies, Institute of Hepatology, UCL, Oxidative Stress in Hepatic Disorders

Dr Greg Qunilan, The Brompton Hospital, IC, Oxidative Stress in Respiratory Critical Care

Research Staff

CARROLL,LAURENCE

PISANESCHI,FEDERICA

Research Student Supervision

ABAS,HOSSAY

EVANS,HELEN

GEORGE,GUILLAUME

HECKENAST,ZSOFIA

HOWELL,SUPINYA

JOURDAIN,ROXANE

MUELLER,MELANIE

MURRAY,JAMES

NIEH,LING-FU