Imperial College London
Alternate

Dr Abigail Clements

Faculty of Natural Sciences, Department of Life Sciences

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 7681a.clements

 
 
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Location

 

1.42Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sanchez:2020:10.1111/cmi.13184,
author = {Sanchez, Garrido J and Slater, SL and Clements, A and Shenoy, A and Frankel, G},
doi = {10.1111/cmi.13184},
journal = {Cellular Microbiology},
pages = {1--19},
title = {Vying for the control of inflammasomes: the cytosolic frontier of enteric bacterial pathogen - host interactions},
url = {http://dx.doi.org/10.1111/cmi.13184},
volume = {22},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Enteric  pathogen-host  interactions occur  at multiple  interfaces,includingthe intestinal epitheliumand deeper organsof the immune system. Microbial ligands and  activities  are detected by  host  sensorsthat  elicit a  range  of  immune responses. Membrane-bound Toll-Like   Receptors   (TLRs) and   cytosolic inflammasomepathways are  key signal  transducers that trigger production of pro-inflammatory molecules such as cytokines and chemokinesand regulate cell deathin response to infection. In recent years, the inflammasomes have emerged as a key  frontier  in  the tusslebetween  bacterial  pathogens  and  the  host. Inflammasomes  are  complexes  that  activate  caspase-1and are regulated  by related caspases, such as caspase-11, -4, -5 and -8.Importantly, enteric bacterial pathogens can  actively  engage  or  evade inflammasome signalling  systems. Extracellular,   vacuolar   and   cytosolic   bacteria   have   developed   divergent strategies to subvert inflammasomes. While some pathogens take advantage of inflammasomeactivation(e.g. Listeria  monocytogenes, Helicobacter  pylori), others(e.g. E. coli, Salmonella, Shigella, Yersinia sp.) deploy a range of virulence factors, mainly type 3 secretion system (T3SS) effectors, that subvert or inhibit inflammasomes.  In  this  review  we focus  on inflammasomepathwaysand  their immune functions  and discuss how  enteric  bacterial  pathogens  interact  with them.These  studies  have  not  only  shed  light  on  the  inflammasome-mediated immunity, but also the exciting area of mammalian cytosolic immune
AU  - Sanchez,Garrido J
AU  - Slater,SL
AU  - Clements,A
AU  - Shenoy,A
AU  - Frankel,G
DO  - 10.1111/cmi.13184
EP  - 19
PY  - 2020///
SN  - 1462-5814
SP  - 1
TI  - Vying for the control of inflammasomes: the cytosolic frontier of enteric bacterial pathogen - host interactions
T2  - Cellular Microbiology
UR  - http://dx.doi.org/10.1111/cmi.13184
UR  - https://onlinelibrary.wiley.com/doi/full/10.1111/cmi.13184
UR  - http://hdl.handle.net/10044/1/77467
VL  - 22
ER  -
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