Publications
118 results found
Jayasena CN, Comninos AN, Stefanopoulou E, et al., 2015, Neurokinin B Administration Induces Hot Flushes in Women, SCIENTIFIC REPORTS, Vol: 5, ISSN: 2045-2322
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- Citations: 70
Jayasena CN, Abbara A, Izzi-Engbeaya C, et al., 2014, Reduced Levels of Plasma Kisspeptin During the Antenatal Booking Visit Are Associated With Increased Risk of Miscarriage, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 99, Pages: E2652-E2660, ISSN: 0021-972X
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- Citations: 48
Jayasena CN, Comninos AN, Narayanaswamy S, et al., 2014, Acute and chronic effects of kisspeptin-54 administration on GH, prolactin and TSH secretion in healthy women, Clinical Endocrinology, Vol: 81, Pages: 891-898, ISSN: 1365-2265
Jayasena CN, Abbara A, Comninos AN, et al., 2014, Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization, Journal of Clinical Investigation, Vol: 124, Pages: 3667-3677, ISSN: 0021-9738
BACKGROUND. Patients with mutations that inactivate kisspeptin signaling are infertile. Kisspeptin-54, the major circulating isoform of kisspeptin in humans, potently stimulates reproductive hormone secretion in humans. Animal studies suggest that kisspeptin is involved in generation of the luteinizing hormone surge, which is required for ovulation; therefore, we hypothesized that kisspeptin-54 could be used to trigger egg maturation in women undergoing in vitro fertilization therapy.METHODS. Following superovulation with recombinant follicle-stimulating hormone and administration of gonadotropin-releasing hormone antagonist to prevent premature ovulation, 53 women were administered a single subcutaneous injection of kisspeptin-54 (1.6 nmol/kg, n = 2; 3.2 nmol/kg, n = 3; 6.4 nmol/kg, n = 24; 12.8 nmol/kg, n = 24) to induce a luteinizing hormone surge and egg maturation. Eggs were retrieved transvaginally 36 hours after kisspeptin injection, assessed for maturation (primary outcome), and fertilized by intracytoplasmic sperm injection with subsequent transfer of one or two embryos.RESULTS. Egg maturation was observed in response to each tested dose of kisspeptin-54, and the mean number of mature eggs per patient generally increased in a dose-dependent manner. Fertilization of eggs and transfer of embryos to the uterus occurred in 92% (49/53) of kisspeptin-54–treated patients. Biochemical and clinical pregnancy rates were 40% (21/53) and 23% (12/53), respectively.CONCLUSION. This study demonstrates that a single injection of kisspeptin-54 can induce egg maturation in women with subfertility undergoing in vitro fertilization therapy. Subsequent fertilization of eggs matured following kisspeptin-54 administration and transfer of resulting embryos can lead to successful human pregnancy.TRIAL REGISTRATION. ClinicalTrials.gov NCT01667406.FUNDING. Medical Research Council, Wellcome Trust, and National Institute for Health Research.
Abbara A, Jayasena CN, Comninos AN, et al., 2014, Kisspeptin - a novel physiological trigger for oocyte maturation in IVF treatment, 30th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 50-50, ISSN: 0268-1161
Comninos AN, Jayasena CN, Stefanopoulou E, et al., 2014, The hypothalamic hormone neurokinin B: a novel therapeutic target for menopausal hot flushes, 30th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 105-105, ISSN: 0268-1161
Jayasena CN, Abbara A, Veldhuis JD, et al., 2014, Increasing LH Pulsatility in Women With Hypothalamic Amenorrhoea Using Intravenous Infusion of Kisspeptin-54, Journal of Clinical Endocrinology and Metabolism, Vol: 99, Pages: E953-E961, ISSN: 0021-972X
Background:Hypothalamic amenorrhea (HA) is the one of the most common causes of period loss in women of reproductive age and is associated with deficient LH pulsatility. High-dose kisspeptin-54 acutely stimulates LH secretion in women with HA, but chronic administration causes desensitization. GnRH has paradoxical effects on reproductive activity; we therefore hypothesized that a dose-dependent therapeutic window exists within which kisspeptin treatment restores the GnRH/LH pulsatility in women with HA.Aim:The aim of the study was to determine whether constant iv infusion of kisspeptin-54 temporarily increases pulsatile LH secretion in women with HA.Methods:Five patients with HA each underwent six assessments of LH pulsatility. Single-blinded continuous iv infusion of vehicle or kisspeptin-54 (0.01, 0.03, 0.10, 0.30, or 1.00 nmol/kg/h) was administered. The LH pulses were detected using blinded deconvolution.Results:Kisspeptin increased LH pulsatility in all patients with HA, with peak responses observed at different doses in each patient. The mean peak number of pulses during infusion of kisspeptin-54 was 3-fold higher when compared with vehicle (number of LH pulses per 8 h: 1.6 ± 0.4, vehicle; 5.0 ± 0.5, kisspeptin-54, P < .01 vs vehicle). The mean peak LH pulse secretory mass during kisspeptin-54 was 6-fold higher when compared with vehicle (LH pulse secretory mass in international units per liter: 3.92 ± 2.31, vehicle; 23.44 ± 12.59, kisspeptin-54; P < .05 vs vehicle).Conclusions:Kisspeptin-54 infusion temporarily increases LH pulsatility in women with HA. Furthermore, we have determined the dose range within which kisspeptin-54 treatment increases basal and pulsatile LH secretion in women with HA. This work provides a basis for studying the potential of kisspeptin-based therapies to treat women with HA.
Comninos AN, Anastasovska J, Sahuri-Arisoylu M, et al., 2014, Kisspeptin Inhibits Neuronal Activity in the Amygdala of Male Mice, ENDOCRINE REVIEWS, Vol: 35, ISSN: 0163-769X
Abbara A, Jayasena CN, Izzi-Engbeaya C, et al., 2014, Plasma Kisspeptin Measurement during Early Pregnancy Is a Highly Predictive Marker of Subsequent Miscarriage, Publisher: ENDOCRINE SOC, ISSN: 0163-769X
Abbara A, Jayasena CN, Comninos AN, et al., 2014, Kisspeptin - a Novel Physiological Trigger for Oocyte Maturation in IVF Treatment, ENDOCRINE REVIEWS, Vol: 35, ISSN: 0163-769X
Jayasena CN, Abbara A, Comninos AN, et al., 2014, Comparing the Effects of Pituitary Versus Hypothalamic Stimulation of the Human Reproductive Axis Using Equimolar Intravenous Infusions of Kisspeptin-10, Kisspeptin-54 and Gonadotrophin Releasing Hormone (GnRH) in Healthy Men, ENDOCRINE REVIEWS, Vol: 35, ISSN: 0163-769X
Comninos AN, Jayasena CN, Stefanopoulou E, et al., 2014, Neurokinin B Administration Induces Menopausal-like Hot Flushes in Healthy Young Women, ENDOCRINE REVIEWS, Vol: 35, ISSN: 0163-769X
Abbara A, Jayasena C, Comninos A, et al., 2014, Kisspeptin: a novel physiological trigger for oocyte maturation in in-vitro fertilisation treatment, LANCET, Vol: 383, Pages: 17-17, ISSN: 0140-6736
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- Citations: 7
Comninos A, Jayasena C, Nijher G, et al., 2014, The effects of kisspeptin administration on the menstrual cycle in healthy women, LANCET, Vol: 383, Pages: 37-37, ISSN: 0140-6736
Jayasena CN, Comninos AN, De Silva A, et al., 2014, Effects of Neurokinin B Administration on Reproductive Hormone Secretion in Healthy Men and Women, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 99, Pages: E19-E27, ISSN: 0021-972X
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- Citations: 30
Jayasena CN, Comninos AN, Nijher GMK, et al., 2013, Twice-Daily Subcutaneous Injection of Kisspeptin-54 Does Not Abolish Menstrual Cyclicity in Healthy Female Volunteers, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 98, Pages: 4464-4474, ISSN: 0021-972X
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- Citations: 22
Jayasena CN, Comninos AN, Veldhuis JD, et al., 2013, A single injection of kisspeptin-54 temporarily increases luteinizing hormone pulsatility in healthy women, CLINICAL ENDOCRINOLOGY, Vol: 79, Pages: 558-563, ISSN: 0300-0664
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- Citations: 37
Comninos AN, Jayasena CN, Nijher GMK, et al., 2013, Chronic kisspeptin administration advances the menstrual cycle in healthy women, 29th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 334-335, ISSN: 0268-1161
Jayasena CN, Abbara A, Comninos AN, et al., 2013, Kisspeptin-54 administration stimulates pulsatile luteinising hormone secretion in women with hypothalamic amenorrhea, 29th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 110-110, ISSN: 0268-1161
Jayasena CN, Comninos AN, Januszewski A, et al., 2012, Plasma Kisspeptin: A Potential Biomarker of Tumor Metastasis in Patients with Ovarian Carcinoma, CLINICAL CHEMISTRY, Vol: 58, Pages: 1061-1063, ISSN: 0009-9147
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- Citations: 12
Jayasena CN, Nijher GMK, Comninos AN, et al., 2011, The Effects of Kisspeptin-10 on Reproductive Hormone Release Show Sexual Dimorphism in Humans, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 96, Pages: E1963-E1972, ISSN: 0021-972X
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- Citations: 89
Jayasena CN, Comninos AN, Clarke H, et al., 2011, The effects of long-term growth hormone and insulin-like growth factor-1 exposure on the development of cardiovascular, cerebrovascular and metabolic co-morbidities in treated patients with acromegaly, CLINICAL ENDOCRINOLOGY, Vol: 75, Pages: 220-225, ISSN: 0300-0664
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- Citations: 44
Troke R, Badman MK, Comninos A, et al., 2010, An unusual complication of hepatic embolisation in a patient with metastatic carcinoid syndrome, 18th International Symposium on Regulatory Peptides, Publisher: ELSEVIER SCIENCE BV, Pages: 15-15, ISSN: 0167-0115
Adjene A, Comninos A, Troke R, et al., 2010, The difficulties of managing an insulinoma in pregnancy, 18th International Symposium on Regulatory Peptides, Publisher: ELSEVIER SCIENCE BV, Pages: 13-13, ISSN: 0167-0115
Badman MK, Troke R, Comninos A, et al., 2010, Multidisciplinary management of metastatic renal carcinoid, 18th International Symposium on Regulatory Peptides, Publisher: ELSEVIER SCIENCE BV, Pages: 13-14, ISSN: 0167-0115
Comninos AN, Badman M, Troke R, et al., 2010, An insulinoma in a patient with tuberous sclerosis: Association or coincidence?, 18th International Symposium on Regulatory Peptides, Publisher: ELSEVIER SCIENCE BV, Pages: 14-14, ISSN: 0167-0115
Day JM, Newman SP, Comninos A, et al., 2003, The effects of 2-substituted oestrogen sulphamates on the growth of prostate and ovarian cancer cells, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, Vol: 84, Pages: 317-325, ISSN: 0960-0760
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- Citations: 31
Comninos AN, Jayasena CN, Dhillo WS, The relationship between gut and adipose hormones, and reproduction, HUMAN REPRODUCTION UPDATE, Vol: 20, Pages: 153-174, ISSN: 1355-4786
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- Citations: 103
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