Imperial College London
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ProfessorAlexanderComninos

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Practice (Endocrinology)
 
 
 
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Contact

 

+44 (0)20 3313 3242a.comninos

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Prague:2019:10.1210/jc.2018-02797,
author = {Prague, J and voliotis, M and Clarke, S and Comninos, A and Abbara, A and Jayasena, C and Roberts, R and Yang, L and veldhuis, J and tsaneva-atanasova, K and mcardle, C and Dhillo, W},
doi = {10.1210/jc.2018-02797},
journal = {Journal of Clinical Endocrinology and Metabolism},
pages = {3628--3636},
title = {Determining the relationship between hot flushes and LH pulses in menopausal women using mathematical modelling},
url = {http://dx.doi.org/10.1210/jc.2018-02797},
volume = {104},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundHypothalamic kisspeptin/neurokinin B/dynorphin (KNDy) neurones regulate LH pulsatility. It is widely accepted that the menopausal hot flush (HF) consistently synchronises with the LH pulse. This suggests that the hypothalamic KNDy neurones are implicated in generating LH pulsatility and HF. Using a modern immunoassay and mathematical modelling we investigated if the HF and LH pulse was consistently synchronised in menopausal women.MethodsEleven menopausal women (51-62yrs experiencing ≥7 HF/24hrs) attended for an 8 hour study where they self-reported HF and underwent peripheral blood sampling every 10 mins. LH pulsatility was determined using two mathematical models: blinded deconvolution analysis and Bayesian spectrum analysis. The probability that the LH pulse and HF event intervals matched was estimated using the interval distributions observed in our data.ResultsNinety-six HF were self-reported, and 82 LH pulses were identified by blinded deconvolution analysis. Using both models, the probability that the two event intervals matched was low in the majority of participants (mean P=0.24 (P=1 reflects perfect association)).InterpretationOur data challenges the widely accepted dogma that HF consistently synchronise with an LH pulse, and so has clinically important therapeutic and mechanistic implications.
AU  - Prague,J
AU  - voliotis,M
AU  - Clarke,S
AU  - Comninos,A
AU  - Abbara,A
AU  - Jayasena,C
AU  - Roberts,R
AU  - Yang,L
AU  - veldhuis,J
AU  - tsaneva-atanasova,K
AU  - mcardle,C
AU  - Dhillo,W
DO  - 10.1210/jc.2018-02797
EP  - 3636
PY  - 2019///
SN  - 0021-972X
SP  - 3628
TI  - Determining the relationship between hot flushes and LH pulses in menopausal women using mathematical modelling
T2  - Journal of Clinical Endocrinology and Metabolism
UR  - http://dx.doi.org/10.1210/jc.2018-02797
UR  - http://hdl.handle.net/10044/1/70172
VL  - 104
ER  -
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