Imperial College London
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ProfessorAlexanderComninos

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Practice (Endocrinology)
 
 
 
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Contact

 

+44 (0)20 3313 3242a.comninos

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Izzi-Engbeaya:2020:clinem/dgaa164,
author = {Izzi-Engbeaya, C and Mills, E and Yang, L and Minnion, J and Tharakan, G and Abbara, A and Comninos, A and Tan, T and Dhillo, W},
doi = {clinem/dgaa164},
journal = {Journal of Clinical Endocrinology and Metabolism},
title = {Acute effects of glucagon on reproductive hormone secretion in healthy men},
url = {http://dx.doi.org/10.1210/clinem/dgaa164},
volume = {105},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ContextGlucagon increases energy expenditure; consequently, glucagon receptor agonists are in development for the treatment of obesity. Obesity negatively affects the reproductive axis, and hypogonadism itself can exacerbate weight gain. Therefore, knowledge of the effects of glucagon receptor agonism on reproductive hormones is important for developing therapeutics for obesity; but reports in the literature about the effects of glucagon receptor agonism on the reproductive axis are conflicting.ObjectiveThe objective of this work is to investigate the effect of glucagon administration on reproductive hormone secretion in healthy young men.DesignA single-blinded, randomized, placebo-controlled crossover study was conducted.SettingThe setting of this study was the Clinical Research Facility, Imperial College Healthcare NHS Trust.ParticipantsEighteen healthy eugonadal men (mean±SEM: age 25.1±1.0 years; body mass index 22.5±0.4 kg/m2; testosterone 21.2±1.2 nmol/L) participated in this study.InterventionAn 8-hour intravenous infusion of 2 pmol/kg/min glucagon or rate-matched vehicle infusion was administered.Main Outcome MeasuresLuteinizing hormone (LH) pulsatility; LH, follicle-stimulating hormone (FSH), and testosterone levels were measured.ResultsAlthough glucagon administration induced metabolic effects (insulin area under the curve: vehicle 1065±292 min.µU/mL vs glucagon 2098±358 min.µU/mL, P<.001), it did not affect LH pulsatility (number of LH pulses/500 min: vehicle 4.7±0.4, glucagon 4.2±0.4, P=.22). Additionally, there were no significant differences in circulating LH, FSH, or testosterone levels during glucagon administration compared with vehicle administration.ConclusionsAcute administration of a metabolically active dose of glucagon does not alter reproductive hormone secretion in healthy men. These data are important for the continued development of glucagon-based tre
AU  - Izzi-Engbeaya,C
AU  - Mills,E
AU  - Yang,L
AU  - Minnion,J
AU  - Tharakan,G
AU  - Abbara,A
AU  - Comninos,A
AU  - Tan,T
AU  - Dhillo,W
DO  - clinem/dgaa164
PY  - 2020///
SN  - 0021-972X
TI  - Acute effects of glucagon on reproductive hormone secretion in healthy men
T2  - Journal of Clinical Endocrinology and Metabolism
UR  - http://dx.doi.org/10.1210/clinem/dgaa164
UR  - http://hdl.handle.net/10044/1/79061
VL  - 105
ER  -
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