Imperial College London
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ProfessorAlexanderComninos

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Practice (Endocrinology)
 
 
 
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Contact

 

+44 (0)20 3313 3242a.comninos

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Behary:2022:10.3389/fendo.2022.923791,
author = {Behary, P and Comninos, A},
doi = {10.3389/fendo.2022.923791},
journal = {Frontiers in Endocrinology},
title = {Bone perspectives in functional hypothalamic amenorrhoea: an update and future avenues},
url = {http://dx.doi.org/10.3389/fendo.2022.923791},
volume = {13},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - One of the most important and potentially long-lasting detrimental consequences of Functional Hypothalamic Amenorrhoea (FHA) ison skeletal homeostasis. Beyond oestrogen deficiency, FHA is associated with a cascade of additional neuro-endocrine and metabolicalterations, some adaptive, but which combine to disrupt skeletal homeostasis. Ultimately, this leads to a two-fold increased riskof fractures in women with FHA compared to healthy eumenorrhoeic women. Although the cornerstone of management ofFHA-related bone loss remains recovery of menses via restoration of metabolic/psychological balance, there is rapidly developingevidence for hormonal manipulations (with a particular emphasis on route of administration) and other pharmacologicaltreatments that can protect or improve skeletal homeostasis in FHA. In this mini-review, we provide an update on thepathophysiology, clinical management and future avenues in the field from a bone perspective.
AU  - Behary,P
AU  - Comninos,A
DO  - 10.3389/fendo.2022.923791
PY  - 2022///
SN  - 1664-2392
TI  - Bone perspectives in functional hypothalamic amenorrhoea: an update and future avenues
T2  - Frontiers in Endocrinology
UR  - http://dx.doi.org/10.3389/fendo.2022.923791
UR  - http://hdl.handle.net/10044/1/97441
VL  - 13
ER  -
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