Imperial College London
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ProfessorAlexanderComninos

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Practice (Endocrinology)
 
 
 
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Contact

 

+44 (0)20 3313 3242a.comninos

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tsoutsouki:2022,
author = {Tsoutsouki, J and Patel, B and Dhillo, W and Abbara, A},
journal = {Frontiers in Endocrinology},
title = {Kisspeptin in the prediction of pregnancy complications},
url = {https://www.frontiersin.org/articles/10.3389/fendo.2022.942664/full},
volume = {13},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Kisspeptin and its receptor are central to reproductive health acting as key regulators of the reproductive endocrine axis in humans. Kisspeptin is most widely recognised as a regulator of gonadotrophin releasing hormone (GnRH) neuronal function. However, recent evidence has demonstrated that kisspeptin and its receptor also play a fundamental role during pregnancy in the regulation of placentation. Kisspeptin is abundantly expressed in syncytiotrophoblasts, and its receptor in both cyto- and syncytio-trophoblasts. Circulating levels of kisspeptin rise dramatically during healthy pregnancy, which have been proposed as having potential as a biomarker of placental function. Indeed, alterations in kisspeptin levels are associated with an increased risk of adverse maternal and foetal complications. This review summarises data evaluating kisspeptin’s role as a putative biomarker of pregnancy complications including miscarriage, ectopic pregnancy (EP), preterm birth (PTB), foetal growth restriction (FGR), hypertensive disorders of pregnancy (HDP), pre-eclampsia (PE), gestational diabetes mellitus (GDM), and gestational trophoblastic disease (GTD).
AU  - Tsoutsouki,J
AU  - Patel,B
AU  - Dhillo,W
AU  - Abbara,A
PY  - 2022///
SN  - 1664-2392
TI  - Kisspeptin in the prediction of pregnancy complications
T2  - Frontiers in Endocrinology
UR  - https://www.frontiersin.org/articles/10.3389/fendo.2022.942664/full
UR  - http://hdl.handle.net/10044/1/97649
VL  - 13
ER  -
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