Imperial College London
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DrAnneCori

Faculty of Medicine, School of Public Health

Senior Lecturer in Infectious Disease Modelling
 
 
 
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Contact

 

+44 (0)20 7594 3229a.cori

 
 
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Location

 

404School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Abbas:2022:10.1101/2022.01.07.22268729,
author = {Abbas, M and Cori, A and Cordey, S and Laubscher, F and Robalo, Nunes T and Myall, A and Salamun, J and Huber, P and Zekry, D and Prendki, V and Iten, A and Vieux, L and Sauvan, V and Graf, CE and Harbarth, S},
doi = {10.1101/2022.01.07.22268729},
title = {Reconstructing transmission chains of SARS-CoV-2 amid multiple outbreaks in a geriatric acute-care hospital},
url = {http://dx.doi.org/10.1101/2022.01.07.22268729},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>There is ongoing uncertainty regarding transmission chains and the respective roles of healthcare workers (HCWs) and elderly patients in nosocomial outbreaks of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in geriatric settings.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We performed a retrospective cohort study including patients with nosocomial coronavirus disease 2019 (COVID-19) in four outbreak-affected wards, and all SARS-CoV-2 RT-PCR positive HCWs from a Swiss university-affiliated geriatric acute-care hospital that admitted both Covid-19 and non-Covid-19 patients during the first pandemic wave in Spring 2020. We combined epidemiological and genetic sequencing data using a Bayesian modelling framework, and reconstructed transmission dynamics of SARS-CoV-2 involving patients and HCWs, in order to determine who infected whom. We evaluated general transmission patterns according to type of case (HCWs working in dedicated Covid-19 cohorting wards: HCW<jats:sub>covid</jats:sub>; HCWs working in non-Covid-19 wards where outbreaks occurred: HCW<jats:sub>outbreak</jats:sub>; patients with nosocomial Covid-19: patient<jats:sub>noso</jats:sub>) by deriving the proportion of infections attributed to each type of case across all posterior trees and comparing them to random expectations.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>During the study period (March 1 to May 7, 2020) we included 180 SARS-CoV-2 positive cases: 127 HCWs (91 HCW<jats:sub>covid</jats:sub>, 36 HCW<jats:sub>outbreak</jats:sub>) and 53 patients. The attack rates ranged from 10-19% for patients, and 21% for HCWs. We estimated that there were 16 importation events (3 patients, 13 HCWs) th
AU  - Abbas,M
AU  - Cori,A
AU  - Cordey,S
AU  - Laubscher,F
AU  - Robalo,Nunes T
AU  - Myall,A
AU  - Salamun,J
AU  - Huber,P
AU  - Zekry,D
AU  - Prendki,V
AU  - Iten,A
AU  - Vieux,L
AU  - Sauvan,V
AU  - Graf,CE
AU  - Harbarth,S
DO  - 10.1101/2022.01.07.22268729
PY  - 2022///
TI  - Reconstructing transmission chains of SARS-CoV-2 amid multiple outbreaks in a geriatric acute-care hospital
UR  - http://dx.doi.org/10.1101/2022.01.07.22268729
ER  -
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