My long-term research interests are focused on understanding the fundamental mechanisms that drive microbial evolution. To this end, I employ a combination of experiments, bioinformatics and computer simulation. Major topics I have contributed to include the emergence of antibiotic resistance, the role of mutation bias in shaping bacterial genome size and composition, and the search for universal principles governing the repeatability of adaptation.
At Imperial College London, I am investigating the evolution of bacterial behaviour, endeavour for which I was awarded a Marie Skłodowska-Curie Fellowship to collaborate with Prof. Martin Buck, a world-leading molecular microbiologist. With this award, I am studying how readily bacterial behaviour can evolve in response to fluctuating selection, gaining insights into the flexibility for rewiring of bacterial signal transduction networks (more info at http://cordis.europa.eu/project/rcn/209320_en.html).
Enquiries from prospective MSc and PhD students are welcome. Postdoc opportunities available here.
Couce Iglesias A, Tenaillon O, 2019, Mutation bias and GC content shape the invasion of antimutator invasions, Nature Communications, Vol:10, ISSN:2041-1723
et al., 2018, Parallel Evolution of High-Level Aminoglycoside Resistance in Escherichia coli Under Low and High Mutation Supply Rates, Frontiers in Microbiology, Vol:9, ISSN:1664-302X
et al., 2017, Mutator genomes decay, despite sustained fitness gains, in a long-term experiment with bacteria, Proceedings of the National Academy of Sciences of the United States of America, Vol:114, ISSN:0027-8424, Pages:E9026-E9035