Imperial College London
Dr Alexessander da Silva Couto Alves

DrAlexessanderda Silva Couto Alves

Faculty of Medicine, School of Public Health

Honorary Research Associate
 
 
 
//

Contact

 

+44 (0)20 7594 3420a.couto-alves

 
 
//

Location

 

150Variety Club WingSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Ramasamy:2012:10.1371/journal.pone.0044008,
author = {Ramasamy, A and Kuokkanen, M and Vedantam, S and Gajdos, ZK and Alves, AC and Lyon, HN and Ferreira, MAR and Strachan, DP and Zhao, JH and Abramson, MJ and Brown, MA and Coin, L and Dharmage, SC and Duffy, DL and Haahtela, T and Heath, AC and Janson, C and Kahonen, M and Khaw, K-T and Laitinen, J and Le, Souef P and Lehtimaki, T and Madden, PAF and Marks, GB and Martin, NG and Matheson, MC and Palmer, CD and Palotie, A and Pouta, A and Robertson, CF and Viikari, J and Widen, E and Wjst, M and Jarvis, DL and Montgomery, GW and Thompson, PJ and Wareham, N and Eriksson, J and Jousilahti, P and Laitinen, T and Pekkanen, J and Raitakari, OT and O'Connor, GT and Salomaa, V and Jarvelin, M-R and Hirschhorn, JN},
doi = {10.1371/journal.pone.0044008},
journal = {PLoS One},
pages = {1--10},
title = {Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA},
url = {http://dx.doi.org/10.1371/journal.pone.0044008},
volume = {7},
year = {2012}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - RationaleAsthma has substantial morbidity and mortality and a strong genetic component, but identification of genetic risk factors is limited by availability of suitable studies.ObjectivesTo test if population-based cohorts with self-reported physician-diagnosed asthma and genome-wide association (GWA) data could be used to validate known associations with asthma and identify novel associations.MethodsThe APCAT (Analysis in Population-based Cohorts of Asthma Traits) consortium consists of 1,716 individuals with asthma and 16,888 healthy controls from six European-descent population-based cohorts. We examined associations in APCAT of thirteen variants previously reported as genome-wide significant (P<5x10−8) and three variants reported as suggestive (P<5×10−7). We also searched for novel associations in APCAT (Stage 1) and followed-up the most promising variants in 4,035 asthmatics and 11,251 healthy controls (Stage 2). Finally, we conducted the first genome-wide screen for interactions with smoking or hay fever.Main ResultsWe observed association in the same direction for all thirteen previously reported variants and nominally replicated ten of them. One variant that was previously suggestive, rs11071559 in RORA, now reaches genome-wide significance when combined with our data (P=2.4×10−9). We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (PStage1+Stage2=1.1x10−9), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (PStage1+Stage2=1.1x10−8), which appears to be independent of previously reported associations in this locus. Finally, we found no strong evidence for gene-environment interactions with smoking or hay fever status.ConclusionsPopulation-based cohorts with simple asthma phenotypes represent a valuable and largely untapped resource for genetic studies of asthma.
AU  - Ramasamy,A
AU  - Kuokkanen,M
AU  - Vedantam,S
AU  - Gajdos,ZK
AU  - Alves,AC
AU  - Lyon,HN
AU  - Ferreira,MAR
AU  - Strachan,DP
AU  - Zhao,JH
AU  - Abramson,MJ
AU  - Brown,MA
AU  - Coin,L
AU  - Dharmage,SC
AU  - Duffy,DL
AU  - Haahtela,T
AU  - Heath,AC
AU  - Janson,C
AU  - Kahonen,M
AU  - Khaw,K-T
AU  - Laitinen,J
AU  - Le,Souef P
AU  - Lehtimaki,T
AU  - Madden,PAF
AU  - Marks,GB
AU  - Martin,NG
AU  - Matheson,MC
AU  - Palmer,CD
AU  - Palotie,A
AU  - Pouta,A
AU  - Robertson,CF
AU  - Viikari,J
AU  - Widen,E
AU  - Wjst,M
AU  - Jarvis,DL
AU  - Montgomery,GW
AU  - Thompson,PJ
AU  - Wareham,N
AU  - Eriksson,J
AU  - Jousilahti,P
AU  - Laitinen,T
AU  - Pekkanen,J
AU  - Raitakari,OT
AU  - O'Connor,GT
AU  - Salomaa,V
AU  - Jarvelin,M-R
AU  - Hirschhorn,JN
DO  - 10.1371/journal.pone.0044008
EP  - 10
PY  - 2012///
SN  - 1932-6203
SP  - 1
TI  - Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA
T2  - PLoS One
UR  - http://dx.doi.org/10.1371/journal.pone.0044008
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000309973900004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044008
UR  - http://hdl.handle.net/10044/1/85519
VL  - 7
ER  -
Download