Imperial College London
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DrAndrewCowburn

Faculty of Medicine, National Heart & Lung Institute

Senior Lecturer (Non-Clinical)
 
 
 
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Contact

 

a.cowburn

 
 
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Location

 

535ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cowburn:2017:10.7554/eLife.28755,
author = {Cowburn, AS and Macias, D and Summers, C and Chilvers, ER and Johnson, RS},
doi = {10.7554/eLife.28755},
journal = {eLife},
title = {Cardiovascular adaptation to hypoxia and the role of peripheral resistance},
url = {http://dx.doi.org/10.7554/eLife.28755},
volume = {6},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Systemic vascular pressure in vertebrates is regulated by a range of factors: one key element of control is peripheral resistance in tissue capillary beds. Many aspects of the relationship between central control of vascular flow and peripheral resistance are unclear. An important example of this is the relationship between hypoxic response in individual tissues, and the effect that response has on systemic cardiovascular adaptation to oxygen deprivation. We show here how hypoxic response via the HIF transcription factors in one large vascular bed, that underlying the skin, influences cardiovascular response to hypoxia in mice. We show that the response of the skin to hypoxia feeds back on a wide range of cardiovascular parameters, including heart rate, arterial pressures, and body temperature. These data represent the first demonstration of a dynamic role for oxygen sensing in a peripheral tissue directly modifying cardiovascular response to the challenge of hypoxia.
AU  - Cowburn,AS
AU  - Macias,D
AU  - Summers,C
AU  - Chilvers,ER
AU  - Johnson,RS
DO  - 10.7554/eLife.28755
PY  - 2017///
SN  - 2050-084X
TI  - Cardiovascular adaptation to hypoxia and the role of peripheral resistance
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.28755
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000413180900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/64520
VL  - 6
ER  -
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