Imperial College London
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DrAndrewCowburn

Faculty of Medicine, National Heart & Lung Institute

Senior Lecturer (Non-Clinical)
 
 
 
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a.cowburn

 
 
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Location

 

535ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sim:2018:10.1016/j.cmet.2018.02.020,
author = {Sim, J and Cowburn, AS and Palazon, A and Madhu, B and Tyrakis, PA and Macias, D and Bargiela, DM and Pietsch, S and Gralla, M and Evans, CE and Kittipassorn, T and Chey, YCJ and Branco, CM and Rundqvist, H and Peet, DJ and Johnson, RS},
doi = {10.1016/j.cmet.2018.02.020},
journal = {Cell Metabolism},
pages = {898--913.e7},
title = {The factor inhibiting HIF asparaginyl hydroxylase regulates oxidative metabolism and accelerates metabolic adaptation to hypoxia},
url = {http://dx.doi.org/10.1016/j.cmet.2018.02.020},
volume = {27},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Animals require an immediate response to oxygen availability to allow rapid shifts between oxidative and glycolytic metabolism. These metabolic shifts are highly regulated by the HIF transcription factor. The factor inhibiting HIF (FIH) is an asparaginyl hydroxylase that controls HIF transcriptional activity in an oxygen-dependent manner. We show here that FIH loss increases oxidative metabolism, while also increasing glycolytic capacity, and that this gives rise to an increase in oxygen consumption. We further show that the loss of FIH acts to accelerate the cellular metabolic response to hypoxia. Skeletal muscle expresses 50-fold higher levels of FIH than other tissues: we analyzed skeletal muscle FIH mutants and found a decreased metabolic efficiency, correlated with an increased oxidative rate and an increased rate of hypoxic response. We find that FIH, through its regulation of oxidation, acts in concert with the PHD/vHL pathway to accelerate HIF-mediated metabolic responses to hypoxia.
AU  - Sim,J
AU  - Cowburn,AS
AU  - Palazon,A
AU  - Madhu,B
AU  - Tyrakis,PA
AU  - Macias,D
AU  - Bargiela,DM
AU  - Pietsch,S
AU  - Gralla,M
AU  - Evans,CE
AU  - Kittipassorn,T
AU  - Chey,YCJ
AU  - Branco,CM
AU  - Rundqvist,H
AU  - Peet,DJ
AU  - Johnson,RS
DO  - 10.1016/j.cmet.2018.02.020
EP  - 913
PY  - 2018///
SN  - 1550-4131
SP  - 898
TI  - The factor inhibiting HIF asparaginyl hydroxylase regulates oxidative metabolism and accelerates metabolic adaptation to hypoxia
T2  - Cell Metabolism
UR  - http://dx.doi.org/10.1016/j.cmet.2018.02.020
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000429089200017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S1550413118301311?via%3Dihub
UR  - http://hdl.handle.net/10044/1/85068
VL  - 27
ER  -
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