Imperial College London
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DrAndrewCowburn

Faculty of Medicine, National Heart & Lung Institute

Senior Lecturer (Non-Clinical)
 
 
 
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Contact

 

a.cowburn

 
 
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Location

 

535ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gassmann:2021:10.1111/bph.15144,
author = {Gassmann, M and Cowburn, A and Gu, H and Li, J and Rodriguez, M and Babicheva, A and Jain, PP and Xiong, M and Gassmann, NN and Yuan, JX-J and Wilkins, MR and Zhao, L},
doi = {10.1111/bph.15144},
journal = {British Journal of Pharmacology},
pages = {121--131},
title = {Hypoxia-induced pulmonary hypertension - utilising experiments of nature},
url = {http://dx.doi.org/10.1111/bph.15144},
volume = {178},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - An increase in pulmonary artery pressure is a common observation in adult mammals exposed to global alveolar hypoxia. It is considered a maladaptive response that places an increased workload on the right ventricle. The mechanisms initiating and maintaining the elevated pressure are of considerable interest to understanding pulmonary vascular homeostasis. There is an expectation that identifying the key molecules in the integrated vascular response to hypoxia will inform potential drug targets. One strategy is to take advantage of experiments of nature; specifically, to understand the genetic basis for the inter-individual variation in the pulmonary vascular response to acute and chronic hypoxia. To date, detailed phenotyping of highlanders has focused on haematocrit and oxygen saturation rather that cardiovascular phenotypes. This review explores what we can learn from those studies with respect to the pulmonary circulation.
AU  - Gassmann,M
AU  - Cowburn,A
AU  - Gu,H
AU  - Li,J
AU  - Rodriguez,M
AU  - Babicheva,A
AU  - Jain,PP
AU  - Xiong,M
AU  - Gassmann,NN
AU  - Yuan,JX-J
AU  - Wilkins,MR
AU  - Zhao,L
DO  - 10.1111/bph.15144
EP  - 131
PY  - 2021///
SN  - 0007-1188
SP  - 121
TI  - Hypoxia-induced pulmonary hypertension - utilising experiments of nature
T2  - British Journal of Pharmacology
UR  - http://dx.doi.org/10.1111/bph.15144
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32464698
UR  - https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15144
UR  - http://hdl.handle.net/10044/1/79928
VL  - 178
ER  -
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