Imperial College London
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Dr Aubrey Cunnington

Faculty of Medicine, Department of Infectious Disease

Professor of Paediatric Infectious Disease
 
 
 
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Contact

 

+44 (0)20 7594 3695a.cunnington

 
 
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Location

 

244Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Knackstedt:2019:10.1126/sciimmunol.aaw0336,
author = {Knackstedt, S and Georgiadou, A and Apel, F and Abu-Abed, U and Moxon, C and Cunnington, A and Raupach, B and Cunningham, D and Langhorne, J and Kruger, R and Barrera, V and Harding, S and Berg, A and Patel, S and Otterdal, K and Mordmuller, B and Schwarzer, E and Brinkman, V and Zychlinsky, A and Amulic, B},
doi = {10.1126/sciimmunol.aaw0336},
journal = {Science Immunology},
pages = {1--17},
title = {Neutrophil extracellular traps drive inflammatory pathogenesis in malaria},
url = {http://dx.doi.org/10.1126/sciimmunol.aaw0336},
volume = {4},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Neutrophils are essential innate immune cells that extrude chromatin in the form of neutrophil extracellular traps (NETs). This form of cell death has potent immunostimulatory activity. We show that heme-induced NETs are essential for malaria pathogenesis. Using patient samples and a mouse model, we define two mechanisms of NET-mediated inflammation of the vasculature: activation of emergency granulopoiesis via GCSF production, and induction of the endothelial cytoadhesion receptor ICAM-1. Soluble NET components facilitate parasite sequestration and mediate tissue destruction. We demonstrate that neutrophils have a key role in malaria immunopathology and propose inhibition of NETs as a treatment strategy in vascular infections.
AU  - Knackstedt,S
AU  - Georgiadou,A
AU  - Apel,F
AU  - Abu-Abed,U
AU  - Moxon,C
AU  - Cunnington,A
AU  - Raupach,B
AU  - Cunningham,D
AU  - Langhorne,J
AU  - Kruger,R
AU  - Barrera,V
AU  - Harding,S
AU  - Berg,A
AU  - Patel,S
AU  - Otterdal,K
AU  - Mordmuller,B
AU  - Schwarzer,E
AU  - Brinkman,V
AU  - Zychlinsky,A
AU  - Amulic,B
DO  - 10.1126/sciimmunol.aaw0336
EP  - 17
PY  - 2019///
SN  - 2470-9468
SP  - 1
TI  - Neutrophil extracellular traps drive inflammatory pathogenesis in malaria
T2  - Science Immunology
UR  - http://dx.doi.org/10.1126/sciimmunol.aaw0336
UR  - https://immunology.sciencemag.org/content/4/40/eaaw0336/tab-pdf
UR  - http://hdl.handle.net/10044/1/71685
VL  - 4
ER  -
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