Imperial College London
Portrait Picture

Dr Aubrey Cunnington

Faculty of Medicine, Department of Infectious Disease

Professor of Paediatric Infectious Disease
 
 
 
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Contact

 

+44 (0)20 7594 3695a.cunnington

 
 
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Location

 

244Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Katsoulis:2021:10.3389/fimmu.2021.651739,
author = {Katsoulis, O and Georgiadou, A and Cunnington, A},
doi = {10.3389/fimmu.2021.651739},
journal = {Frontiers in Immunology},
title = {Immunopathology of acute kidney injury in severe malaria},
url = {http://dx.doi.org/10.3389/fimmu.2021.651739},
volume = {12},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Acute kidney injury (AKI) is a common feature of severe malaria, and an independent risk factor for death. Previous research has suggested that an overactivation of the host inflammatory response is at least partly involved in mediating the kidney damage observed in P. falciparum patients with AKI, however the exact pathophysiology of AKI in severe malaria remains unknown. The purpose of this mini-review is to describe how different aspects of malaria pathology, including parasite sequestration, microvascular obstruction and extensive intravascular hemolysis, may interact with each other and contribute to the development of AKI in severe malaria, by amplifying the damaging effects of the host inflammatory response. Here, we highlight the importance of considering how the systemic effects and multi-organ involvement of malaria are intertwined with the localized effects on the kidney.
AU  - Katsoulis,O
AU  - Georgiadou,A
AU  - Cunnington,A
DO  - 10.3389/fimmu.2021.651739
PY  - 2021///
SN  - 1664-3224
TI  - Immunopathology of acute kidney injury in severe malaria
T2  - Frontiers in Immunology
UR  - http://dx.doi.org/10.3389/fimmu.2021.651739
UR  - http://hdl.handle.net/10044/1/89391
VL  - 12
ER  -
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