Imperial College London
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Dr Aubrey Cunnington

Faculty of Medicine, Department of Infectious Disease

Professor of Paediatric Infectious Disease
 
 
 
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Contact

 

+44 (0)20 7594 3695a.cunnington

 
 
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Location

 

244Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hamilton:2023:10.1016/j.ijid.2023.02.008,
author = {Hamilton, F and Mitchell, R and Constantinescu, A and Hughes, D and Cunnington, A and Ghazal, P and Timpson, NJ},
doi = {10.1016/j.ijid.2023.02.008},
journal = {International Journal of Infectious Diseases},
pages = {251--259},
title = {The effect of IL-6 signalling on severe malaria: a Mendelian randomisation analysis},
url = {http://dx.doi.org/10.1016/j.ijid.2023.02.008},
volume = {129},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectivesSevere malaria remains a deadly disease for many young children in low- and middle-income countries. Levels of interleukin (IL)-6 have been shown to identify cases of severe malaria and associate with severity, but it is unknown if this association is causal.MethodsA single nucleotide polymorphism (SNP; rs2228145) in the IL-6 receptor was chosen as a genetic variant that is known to alter IL-6 signaling. We tested this, then took this forward as an instrument to perform Mendelian randomization (MR) in MalariaGEN, a large cohort study of patients with severe malaria at 11 worldwide sites.ResultsIn MR analyses using rs2228145, we did not identify an effect of decreased IL-6 signaling on severe malaria (odds ratio 1.14, 95% confidence interval 0.56-2.34, P = 0.713). The estimates of the association with any severe malaria subphenotype were similarly null, although with some imprecision. Further analyses using other MR approaches had similar results.ConclusionThese analyses do not support a causal role for IL-6 signaling in the development of severe malaria. This result suggests IL-6 may not be causal for severe outcomes in malaria, and that therapeutic manipulation of IL-6 is unlikely to be a suitable treatment for severe malaria.
AU  - Hamilton,F
AU  - Mitchell,R
AU  - Constantinescu,A
AU  - Hughes,D
AU  - Cunnington,A
AU  - Ghazal,P
AU  - Timpson,NJ
DO  - 10.1016/j.ijid.2023.02.008
EP  - 259
PY  - 2023///
SN  - 1201-9712
SP  - 251
TI  - The effect of IL-6 signalling on severe malaria: a Mendelian randomisation analysis
T2  - International Journal of Infectious Diseases
UR  - http://dx.doi.org/10.1016/j.ijid.2023.02.008
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36801374
UR  - http://sciencedirect.com/science/article/pii/S1201971223000565?via%3Dihub
UR  - http://hdl.handle.net/10044/1/102177
VL  - 129
ER  -
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