Imperial College London
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ProfessorAdnanCustovic

Faculty of Medicine, National Heart & Lung Institute

Professor of Paediatric Allergy
 
 
 
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Location

 

220Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Diamant:2019:10.1111/all.13806,
author = {Diamant, Z and Vijverberg, S and Alving, K and Bakirtas, A and Bjermer, L and Custovic, A and Dahlen, S-E and Gaga, M and Gerth, van Wijk R and Del, Giacco S and Hamelmann, E and Heaney, L and Heffler, E and Kalayci, Ö and Kostikas, K and Lutter, R and Olin, A-C and Sergejeva, S and Simpson, A and Sterk, PJ and Tufvesson, E and Agache, I and Seys, SF},
doi = {10.1111/all.13806},
journal = {Allergy},
pages = {1835--1851},
title = {Toward clinically applicable biomarkers for asthma: An EAACI position paper},
url = {http://dx.doi.org/10.1111/all.13806},
volume = {74},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Inflammation, structural and functional abnormalities within the airways are key features of asthma. Although these processes are well-documented, their expression varies across the heterogeneous spectrum of asthma. Type 2 inflammatory responses are characterized by increased levels of eosinophils, FeNO and type 2 cytokines in blood and/or airways. Presently, type 2 asthma is the best-defined endotype, typically found in patients with allergic asthma, but surprisingly also in non-allergic patients with (severe) asthma. The etiology of asthma with non-type 2 inflammation is less clear. During the past decade, targeted therapies, including biologicals and small molecules, have been increasingly integrated into treatment strategies of severe asthma. These treatments block specific inflammatory pathways or single mediators. Single or composite biomarkers help to identify patients who will benefit from these treatments. So far, only a few inflammatory biomarkers have been validated for clinical application. The European Academy of Allergy & Clinical Immunology (EAACI) Task Force on Biomarkers in Asthma was initiated to review different biomarker sampling methods and to investigate clinical applicability of new and existing inflammatory biomarkers (point-of-care) to support diagnosis, targeted treatment and monitoring of severe asthma. Subsequently, we discuss existing and novel targeted therapies for asthma as well as applicable biomarkers.
AU  - Diamant,Z
AU  - Vijverberg,S
AU  - Alving,K
AU  - Bakirtas,A
AU  - Bjermer,L
AU  - Custovic,A
AU  - Dahlen,S-E
AU  - Gaga,M
AU  - Gerth,van Wijk R
AU  - Del,Giacco S
AU  - Hamelmann,E
AU  - Heaney,L
AU  - Heffler,E
AU  - Kalayci,Ö
AU  - Kostikas,K
AU  - Lutter,R
AU  - Olin,A-C
AU  - Sergejeva,S
AU  - Simpson,A
AU  - Sterk,PJ
AU  - Tufvesson,E
AU  - Agache,I
AU  - Seys,SF
DO  - 10.1111/all.13806
EP  - 1851
PY  - 2019///
SN  - 0105-4538
SP  - 1835
TI  - Toward clinically applicable biomarkers for asthma: An EAACI position paper
T2  - Allergy
UR  - http://dx.doi.org/10.1111/all.13806
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30953574
UR  - http://hdl.handle.net/10044/1/71172
VL  - 74
ER  -
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