Imperial College London
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ProfessorAdnanCustovic

Faculty of Medicine, National Heart & Lung Institute

Professor of Paediatric Allergy
 
 
 
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a.custovic CV

 
 
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Location

 

220Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bradfield:2019:hmg/ddz161,
author = {Bradfield, JP and Vogelezang, S and Felix, JF and Chesi, A and Helgeland, Ø and Horikoshi, M and Karhunen, V and Lowry, E and Cousminer, DL and Ahluwalia, TS and Thiering, E and Boh, ET-H and Zafarmand, MH and Vilor-Tejedor, N and Wang, CA and Joro, R and Chen, Z and Gauderman, WJ and Pitkänen, N and Parra, EJ and Fernandez-Rhodes, L and Alyass, A and Monnereau, C and Curtin, JA and Have, CT and McCormack, SE and Hollensted, M and Frithioff-Bøjsøe, C and Valladares-Salgado, A and Peralta-Romero, J and Teo, Y-Y and Standl, M and Leinonen, JT and Holm, J-C and Peters, T and Vioque, J and Vrijheid, M and Simpson, A and Custovic, A and Vaudel, M and Canouil, M and Lindi, V and Atalay, M and Kähönen, M and Raitakari, OT and van, Schaik BDC and Berkowitz, RI and Cole, SA and Voruganti, VS and Wang, Y and Highland, HM and Comuzzie, AG and Butte, NF and Justice, AE and Gahagan, S and Blanco, E and Lehtimäki, T and Lakka, TA and Hebebrand, J and Bonnefond, A and Grarup, N and Froguel, P and Lyy},
doi = {hmg/ddz161},
journal = {Human Molecular Genetics},
pages = {3327--3338},
title = {A trans-ancestral meta-analysis of Genome-wide Association Studies reveals loci associated with childhood obesity},
url = {http://dx.doi.org/10.1093/hmg/ddz161},
volume = {28},
year = {2019}
}
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TY  - JOUR
AB  - Although hundreds of GWAS-implicated loci have been reported for adult obesity-related traits, less is known about the genetics specific for early-onset obesity, and with only a few studies conducted in non-European populations to date. Searching for additional genetic variants associated with childhood obesity, we performed a trans-ancestral meta-analysis of thirty studies consisting of up to 13,005 cases (≥95th percentile of BMI achieved 2-18 years old) and 15,599 controls (consistently <50th percentile of BMI) of European, African, North/South American and East Asian ancestry. Suggestive loci were taken forward for replication in a sample of 1,888 cases and 4,689 controls from seven cohorts of European and North/South American ancestry. In addition to observing eighteen previously implicated BMI or obesity loci, for both early and late onset, we uncovered one completely novel locus in this trans-ancestral analysis (nearest gene: METTL15). The variant was nominally associated in only the European subgroup analysis but had a consistent direction of effect in other ethnicities. We then utilized trans-ancestral Bayesian analysis to narrow down the location of the probable causal variant at each genome-wide significant signal. Of all the fine-mapped loci, we were able to narrow down the causative variant at four known loci to fewer than ten SNPs (FAIM2, GNPDA2, MC4R and SEC16B loci). In conclusion, an ethnically diverse setting has enabled us to both identify an additional pediatric obesity locus and further fine-map existing loci.
AU  - Bradfield,JP
AU  - Vogelezang,S
AU  - Felix,JF
AU  - Chesi,A
AU  - Helgeland,Ø
AU  - Horikoshi,M
AU  - Karhunen,V
AU  - Lowry,E
AU  - Cousminer,DL
AU  - Ahluwalia,TS
AU  - Thiering,E
AU  - Boh,ET-H
AU  - Zafarmand,MH
AU  - Vilor-Tejedor,N
AU  - Wang,CA
AU  - Joro,R
AU  - Chen,Z
AU  - Gauderman,WJ
AU  - Pitkänen,N
AU  - Parra,EJ
AU  - Fernandez-Rhodes,L
AU  - Alyass,A
AU  - Monnereau,C
AU  - Curtin,JA
AU  - Have,CT
AU  - McCormack,SE
AU  - Hollensted,M
AU  - Frithioff-Bøjsøe,C
AU  - Valladares-Salgado,A
AU  - Peralta-Romero,J
AU  - Teo,Y-Y
AU  - Standl,M
AU  - Leinonen,JT
AU  - Holm,J-C
AU  - Peters,T
AU  - Vioque,J
AU  - Vrijheid,M
AU  - Simpson,A
AU  - Custovic,A
AU  - Vaudel,M
AU  - Canouil,M
AU  - Lindi,V
AU  - Atalay,M
AU  - Kähönen,M
AU  - Raitakari,OT
AU  - van,Schaik BDC
AU  - Berkowitz,RI
AU  - Cole,SA
AU  - Voruganti,VS
AU  - Wang,Y
AU  - Highland,HM
AU  - Comuzzie,AG
AU  - Butte,NF
AU  - Justice,AE
AU  - Gahagan,S
AU  - Blanco,E
AU  - Lehtimäki,T
AU  - Lakka,TA
AU  - Hebebrand,J
AU  - Bonnefond,A
AU  - Grarup,N
AU  - Froguel,P
AU  - Lyytikäinen,L-P
AU  - Cruz,M
AU  - Kobes,S
AU  - Hanson,RL
AU  - Zemel,BS
AU  - Hinney,A
AU  - Teo,KK
AU  - Meyre,D
AU  - North,KE
AU  - Gilliland,FD
AU  - Bisgaard,H
AU  - Bustamante,M
AU  - Bonnelykke,K
AU  - Pennell,CE
AU  - Rivadeneira,F
AU  - Uitterlinden,AG
AU  - Baier,LJ
AU  - Vrijkotte,TGM
AU  - Heinrich,J
AU  - Sørensen,TIA
AU  - Saw,S-M
AU  - Pedersen,O
AU  - Hansen,T
AU  - Eriksson,J
AU  - Widén,E
AU  - McCarthy,MI
AU  - Njølstad,PR
AU  - Power,C
AU  - Hyppönen,E
AU  - Sebert,S
AU  - Brown,CD
AU  - Järvelin,M-R
AU  - Timpson,NJ
AU  - Johansson,S
AU  - Hakonarson,H
AU  - Jaddoe,VWV
AU  - Grant,SFA
AU  - Early,Growth Genetics Consortium
DO  - hmg/ddz161
EP  - 3338
PY  - 2019///
SN  - 0964-6906
SP  - 3327
TI  - A trans-ancestral meta-analysis of Genome-wide Association Studies reveals loci associated with childhood obesity
T2  - Human Molecular Genetics
UR  - http://dx.doi.org/10.1093/hmg/ddz161
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31504550
UR  - https://academic.oup.com/hmg/article/28/19/3327/5528371
UR  - http://hdl.handle.net/10044/1/73565
VL  - 28
ER  -
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