Imperial College London
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ProfessorAdnanCustovic

Faculty of Medicine, National Heart & Lung Institute

Professor of Paediatric Allergy
 
 
 
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220Medical SchoolSt Mary's Campus

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Publications

Citation

BibTex format

@article{Mathioudakis:2020:10.1016/j.jaip.2020.01.059,
author = {Mathioudakis, AG and Custovic, A and Deschildre, A and Ducharme, FM and Kalayci, O and Murray, C and Garcia, AN and Phipatanakul, W and Price, D and Sheikh, A and Agache, I and Bacharier, L and Bonini, M and Castro-Rodriguez, JA and De, Carlo G and Craig, T and Diamant, Z and Feleszko, W and Ierodiakonou, D and Gern, JE and Grigg, J and Hedlin, G and Hossny, EM and Jartti, T and Kaplan, A and Lemanske, RF and Le, Souef P and Makela, MJ and Matricardi, PM and Miligkos, M and Morais-Almeida, M and Pite, H and Pitrez, PMC and Pohunek, P and Roberts, G and Sanchez-Garcia, S and Tsiligianni, I and Turner, S and Winders, TA and Wong, G and Xepapadaki, P and Zar, HJ and Papadopoulos, NG},
doi = {10.1016/j.jaip.2020.01.059},
journal = {Journal of Allergy and Clinical Immunology: In Practice},
pages = {1953--1960.e9},
title = {Research priorities in pediatric asthma: results of a global survey of multiple stakeholder groups by the Pediatric Asthma in Real Life (PeARL) Think Tank},
url = {http://dx.doi.org/10.1016/j.jaip.2020.01.059},
volume = {8},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Pediatric asthma remains a public health challenge with enormous impact worldwide. OBJECTIVE: The aim of this study was to identify and prioritize unmet clinical needs in pediatric asthma, which could be used to guide future research and policy activities. METHODS: We first identified unmet needs through an open-question survey administered to international experts in pediatric asthma who were members of the Pediatric Asthma in Real Life Think Tank. Prioritization of topics was then achieved through a second, extensive survey with global reach, of multiple stakeholders (leading experts, researchers, clinicians, patients, policy makers, and the pharmaceutical industry). Differences across responder groups were compared. RESULTS: A total of 57 unmet clinical need topics identified by international experts were prioritized by 412 participants from 5 continents and 60 countries. Prevention of disease progression and prediction of future risk, including persistence into adulthood, emerged as the most urgent research questions. Stratified care, based on biomarkers, clinical phenotypes, the children's age, and demographics were also highly rated. The identification of minimum diagnostic criteria in different age groups, cultural perceptions of asthma, and best treatment by age group were priorities for responders from low-middle-income countries. There was good agreement across different stakeholder groups in all domains with some notable exceptions that highlight the importance of involving the whole range of stakeholders in formulation of recommendations. CONCLUSIONS: Different stakeholders agree in the majority of research and strategic (eg, prevention, personalized approach) priorities for pediatric asthma. Stakeholder diversity is crucial for highlighting divergent issues that future guidelines should consider.
AU  - Mathioudakis,AG
AU  - Custovic,A
AU  - Deschildre,A
AU  - Ducharme,FM
AU  - Kalayci,O
AU  - Murray,C
AU  - Garcia,AN
AU  - Phipatanakul,W
AU  - Price,D
AU  - Sheikh,A
AU  - Agache,I
AU  - Bacharier,L
AU  - Bonini,M
AU  - Castro-Rodriguez,JA
AU  - De,Carlo G
AU  - Craig,T
AU  - Diamant,Z
AU  - Feleszko,W
AU  - Ierodiakonou,D
AU  - Gern,JE
AU  - Grigg,J
AU  - Hedlin,G
AU  - Hossny,EM
AU  - Jartti,T
AU  - Kaplan,A
AU  - Lemanske,RF
AU  - Le,Souef P
AU  - Makela,MJ
AU  - Matricardi,PM
AU  - Miligkos,M
AU  - Morais-Almeida,M
AU  - Pite,H
AU  - Pitrez,PMC
AU  - Pohunek,P
AU  - Roberts,G
AU  - Sanchez-Garcia,S
AU  - Tsiligianni,I
AU  - Turner,S
AU  - Winders,TA
AU  - Wong,G
AU  - Xepapadaki,P
AU  - Zar,HJ
AU  - Papadopoulos,NG
DO  - 10.1016/j.jaip.2020.01.059
EP  - 1960
PY  - 2020///
SN  - 2213-2198
SP  - 1953
TI  - Research priorities in pediatric asthma: results of a global survey of multiple stakeholder groups by the Pediatric Asthma in Real Life (PeARL) Think Tank
T2  - Journal of Allergy and Clinical Immunology: In Practice
UR  - http://dx.doi.org/10.1016/j.jaip.2020.01.059
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32146166
UR  - http://hdl.handle.net/10044/1/81261
VL  - 8
ER  -
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