Imperial College London
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ProfessorAdnanCustovic

Faculty of Medicine, National Heart & Lung Institute

Professor of Paediatric Allergy
 
 
 
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a.custovic CV

 
 
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Location

 

220Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Custovic:2020:10.1080/1744666X.2020.1816825,
author = {Custovic, A and Custovic, D and Kljaic, Bukvic B and Fontanella, S and Haider, S},
doi = {10.1080/1744666X.2020.1816825},
journal = {Expert Review of Clinical Immunology},
pages = {873--881},
title = {Atopic phenotypes and their implication in the atopic march},
url = {http://dx.doi.org/10.1080/1744666X.2020.1816825},
volume = {16},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Eczema, allergic rhinitis, and asthma are traditionally considered atopic (or allergic) diseases. They are complex, multifactorial, and are caused by a variety of different mechanisms, which result in multiple heterogeneous clinical phenotypes. Atopic march is usually interpreted as the sequential development of symptoms from eczema in infancy, to asthma, and then allergic rhinitis. Areas covered: The authors reviewed the evidence on the multimorbidity of eczema, asthma, and rhinitis, and the implication of results of data-driven analyses on the concept framework of atopic march. A literature search was conducted in the PubMed and Web of Science for peer-reviewed articles published until July 2020. Application of Bayesian machine learning framework to rich phenotypic data from birth cohorts demonstrated that the postulated linear progression of symptoms (atopic march) does not capture the heterogeneity of allergic phenotypes. Expert opinion: Eczema, wheeze, and rhinitis co-exist more often than would be expected by chance, but their relationship can be best understood in a multimorbidity framework, rather than through atopic march sequence. The observation of their co-occurrence does not imply any specific relationship between them, and certainly not a progressive or causal one. It is unlikely that a sngle mechanism such as allergic sensitization underpins different multimorbidity manifestations.
AU  - Custovic,A
AU  - Custovic,D
AU  - Kljaic,Bukvic B
AU  - Fontanella,S
AU  - Haider,S
DO  - 10.1080/1744666X.2020.1816825
EP  - 881
PY  - 2020///
SN  - 1744-666X
SP  - 873
TI  - Atopic phenotypes and their implication in the atopic march
T2  - Expert Review of Clinical Immunology
UR  - http://dx.doi.org/10.1080/1744666X.2020.1816825
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000569447000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.tandfonline.com/doi/full/10.1080/1744666X.2020.1816825
UR  - http://hdl.handle.net/10044/1/86318
VL  - 16
ER  -
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