Imperial College London
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ProfessorAdnanCustovic

Faculty of Medicine, National Heart & Lung Institute

Professor of Paediatric Allergy
 
 
 
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a.custovic CV

 
 
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Location

 

220Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vogelezang:2020:10.1371/journal.pgen.1008718,
author = {Vogelezang, S and Bradfield, JP and Ahluwalia, TS and Curtin, JA and Lakka, TA and Grarup, N and Scholz, M and van, der Most PJ and Monnereau, C and Stergiakouli, E and Heiskala, A and Horikoshi, M and Fedko, IO and Vilor-Tejedor, N and Cousminer, DL and Standl, M and Wang, CA and Viikari, J and Geller, F and iniguez, C and Pitkanen, N and Chesi, A and Bacelis, J and Yengo, L and Torrent, M and Ntalla, I and Helgeland, O and Selzam, S and Vonk, JM and Zafarmand, MH and Heude, B and Farooqi, IS and Alyass, A and Beaumont, RN and Have, CT and Rzehak, P and Bilbao, JR and Schnurr, TM and Barroso, I and Bonnelykke, K and Beilin, LJ and Carstensen, L and Charles, M-A and Chawes, B and Clement, K and Closa-Monasterolo, R and Custovic, A and Eriksson, JG and Escribano, J and Groen-Blokhuis, M and Grote, V and Gruszfeld, D and Hakonarson, H and Hansen, T and Hattersley, AT and Hollensted, M and Hottenga, J-J and Hypponen, E and Johansson, S and Joro, R and Kahonen, M and Karhunen, V and Kiess,},
doi = {10.1371/journal.pgen.1008718},
journal = {PLoS Genetics},
pages = {1--26},
title = {Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits},
url = {http://dx.doi.org/10.1371/journal.pgen.1008718},
volume = {16},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.
AU  - Vogelezang,S
AU  - Bradfield,JP
AU  - Ahluwalia,TS
AU  - Curtin,JA
AU  - Lakka,TA
AU  - Grarup,N
AU  - Scholz,M
AU  - van,der Most PJ
AU  - Monnereau,C
AU  - Stergiakouli,E
AU  - Heiskala,A
AU  - Horikoshi,M
AU  - Fedko,IO
AU  - Vilor-Tejedor,N
AU  - Cousminer,DL
AU  - Standl,M
AU  - Wang,CA
AU  - Viikari,J
AU  - Geller,F
AU  - iniguez,C
AU  - Pitkanen,N
AU  - Chesi,A
AU  - Bacelis,J
AU  - Yengo,L
AU  - Torrent,M
AU  - Ntalla,I
AU  - Helgeland,O
AU  - Selzam,S
AU  - Vonk,JM
AU  - Zafarmand,MH
AU  - Heude,B
AU  - Farooqi,IS
AU  - Alyass,A
AU  - Beaumont,RN
AU  - Have,CT
AU  - Rzehak,P
AU  - Bilbao,JR
AU  - Schnurr,TM
AU  - Barroso,I
AU  - Bonnelykke,K
AU  - Beilin,LJ
AU  - Carstensen,L
AU  - Charles,M-A
AU  - Chawes,B
AU  - Clement,K
AU  - Closa-Monasterolo,R
AU  - Custovic,A
AU  - Eriksson,JG
AU  - Escribano,J
AU  - Groen-Blokhuis,M
AU  - Grote,V
AU  - Gruszfeld,D
AU  - Hakonarson,H
AU  - Hansen,T
AU  - Hattersley,AT
AU  - Hollensted,M
AU  - Hottenga,J-J
AU  - Hypponen,E
AU  - Johansson,S
AU  - Joro,R
AU  - Kahonen,M
AU  - Karhunen,V
AU  - Kiess,W
AU  - Knight,BA
AU  - Koletzko,B
AU  - Kuehnapfel,A
AU  - Landgraf,K
AU  - Langhendries,J-P
AU  - Lehtimaki,T
AU  - Leinonen,JT
AU  - Li,A
AU  - Lindi,V
AU  - Lowry,E
AU  - Bustamante,M
AU  - Medina-Gomez,C
AU  - Melbye,M
AU  - Michaelsen,KF
AU  - Morgen,CS
AU  - Mori,TA
AU  - Nielsen,TRH
AU  - Niinikoski,H
AU  - Oldehinkel,AJ
AU  - Pahkala,K
AU  - Panoutsopoulou,K
AU  - Pedersen,O
AU  - Pennell,CE
AU  - Power,C
AU  - Reijneveld,SA
AU  - Rivadeneira,F
AU  - Simpson,A
AU  - Sly,PD
AU  - Stokholm,J
AU  - Teo,KK
AU  - Thiering,E
AU  - Timpson,NJ
AU  - Uitterlinden,AG
AU  - van,Beijsterveldt CEM
AU  - van,Schaik BDC
AU  - Vaudel,M
AU  - Verduci,E
AU  - Vinding,RK
AU  - Vogel,M
AU  - Zeggini,E
AU  - Sebert,S
AU  - Lind,MV
AU  - Brown,CD
AU  - Santa-Marina,L
AU  - Reischl,E
AU  - Frithioff-Bojsoe,C
AU  - Meyre,D
AU  - Wheeler,E
AU  - Ong,K
AU  - Nohr,EA
AU  - Vrijkotte,TGM
AU  - Koppelman,GH
AU  - Plomin,R
AU  - Njolstad,PR
AU  - Dedoussis,GD
AU  - Froguel,P
AU  - Sorensen,TIA
AU  - Jacobsson,B
AU  - Freathy,RM
AU  - Zemel,BS
AU  - Raitakari,O
AU  - Vrijheid,M
AU  - Feenstra,B
AU  - Lyytikainen,L-P
AU  - Snieder,H
AU  - Kirsten,H
AU  - Holt,PG
AU  - Heinrich,J
AU  - Widen,E
AU  - Sunyer,J
AU  - Boomsma,DI
AU  - Jarvelin,M-R
AU  - Koerner,A
AU  - Davey,Smith G
AU  - Holm,J-C
AU  - Atalay,M
AU  - Murray,C
AU  - Bisgaard,H
AU  - McCarthy,MI
AU  - Jaddoe,VWV
AU  - Grant,SFA
AU  - Felix,JF
DO  - 10.1371/journal.pgen.1008718
EP  - 26
PY  - 2020///
SN  - 1553-7390
SP  - 1
TI  - Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
T2  - PLoS Genetics
UR  - http://dx.doi.org/10.1371/journal.pgen.1008718
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000582197600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008718
UR  - http://hdl.handle.net/10044/1/85481
VL  - 16
ER  -
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