Imperial College London
Alternate

Professor the Lord Darzi of Denham PC KBE FRS FMedSci HonFREng

Faculty of Medicine, Department of Surgery & Cancer

Co-Director of the IGHI, Professor of Surgery
 
 
 
//

Contact

 

+44 (0)20 3312 1310a.darzi

 
 
//

Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Eales:2022:10.1038/s41467-022-32096-4,
author = {Eales, O and Martins, LDO and Page, AJ and Wang, H and Bodinier, B and Tang, D and Haw, D and Jonnerby, J and Atchison, C and Ashby, D and Barclay, W and Taylor, G and Cooke, G and Ward, H and Darzi, A and Riley, S and Elliott, P and Donnelly, CA and Chadeau-Hyam, M},
doi = {10.1038/s41467-022-32096-4},
journal = {Nature Communications},
title = {Dynamics of competing SARS-CoV-2 variants during the Omicron epidemic in England},
url = {http://dx.doi.org/10.1038/s41467-022-32096-4},
volume = {13},
year = {2022}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The SARS-CoV-2 pandemic has been characterised by the regular emergence of genomic variants. With natural and vaccine-induced population immunity at high levels, evolutionary pressure favours variants better able to evade SARS-CoV-2 neutralising antibodies. The Omicron variant (first detected in November 2021) exhibited a high degree of immune evasion, leading to increased infection rates worldwide. However, estimates of the magnitude of this Omicron wave have often relied on routine testing data, which are prone to several biases. Using data from the REal-time Assessment of Community Transmission-1 (REACT-1) study, a series of cross-sectional surveys assessing prevalence of SARS-CoV-2 infection in England, we estimated the dynamics of England’s Omicron wave (from 9 September 2021 to 1 March 2022). We estimate an initial peak in national Omicron prevalence of 6.89% (5.34%, 10.61%) during January 2022, followed by a resurgence in SARS-CoV-2 infections as the more transmissible Omicron sub-lineage, BA.2 replaced BA.1 and BA.1.1. Assuming the emergence of further distinct variants, intermittent epidemics of similar magnitudes may become the ‘new normal’.
AU  - Eales,O
AU  - Martins,LDO
AU  - Page,AJ
AU  - Wang,H
AU  - Bodinier,B
AU  - Tang,D
AU  - Haw,D
AU  - Jonnerby,J
AU  - Atchison,C
AU  - Ashby,D
AU  - Barclay,W
AU  - Taylor,G
AU  - Cooke,G
AU  - Ward,H
AU  - Darzi,A
AU  - Riley,S
AU  - Elliott,P
AU  - Donnelly,CA
AU  - Chadeau-Hyam,M
DO  - 10.1038/s41467-022-32096-4
PY  - 2022///
SN  - 2041-1723
TI  - Dynamics of competing SARS-CoV-2 variants during the Omicron epidemic in England
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-022-32096-4
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000833074200026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41467-022-32096-4
UR  - http://hdl.handle.net/10044/1/99418
VL  - 13
ER  -
Download