Imperial College London
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ProfessorAlfonsoDe Simone

Faculty of Natural Sciences, Department of Life Sciences

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3052a.de-simon Website

 
 
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Location

 

603Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gonzalez-Garcia:2021:10.3389/fcell.2021.642623,
author = {Gonzalez-Garcia, M and Fusco, G and De, Simone A},
doi = {10.3389/fcell.2021.642623},
journal = {Frontiers in Cell and Developmental Biology},
pages = {1--12},
title = {Membrane interactions and toxicity by misfolded protein oligomers},
url = {http://dx.doi.org/10.3389/fcell.2021.642623},
volume = {9},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The conversion of otherwise soluble proteins into insoluble amyloid aggregates is associated with a range of neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases, as well as non-neuropathic conditions such as type II diabetes and systemic amyloidoses. It is increasingly evident that the most pernicious species among those forming during protein aggregation are small prefibrillar oligomers. In this review, we describe the recent progress in the characterization of the cellular and molecular interactions by toxic misfolded protein oligomers. A fundamental interaction by these aggregates involves biological membranes, resulting in two major model mechanisms at the onset of the cellular toxicity. These include the membrane disruption model, resulting in calcium imbalance, mitochondrial dysfunction and intracellular reactive oxygen species, and the direct interaction with membrane proteins, leading to the alteration of their native function. A key challenge remains in the characterization of transient interactions involving heterogeneous protein aggregates. Solving this task is crucial in the quest of identifying suitable therapeutic approaches to suppress the cellular toxicity in protein misfolding diseases.
AU  - Gonzalez-Garcia,M
AU  - Fusco,G
AU  - De,Simone A
DO  - 10.3389/fcell.2021.642623
EP  - 12
PY  - 2021///
SN  - 2296-634X
SP  - 1
TI  - Membrane interactions and toxicity by misfolded protein oligomers
T2  - Frontiers in Cell and Developmental Biology
UR  - http://dx.doi.org/10.3389/fcell.2021.642623
UR  - https://www.frontiersin.org/articles/10.3389/fcell.2021.642623/full
UR  - http://hdl.handle.net/10044/1/87834
VL  - 9
ER  -
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