Publications

BibTex format

@article{Elliott:2020:10.1161/HYPERTENSIONAHA.119.14302,
author = {Elliott, P and Muller, DC and Schneider-Luftman, D and Pazoki, R and Evangelou, E and Dehghan, A and Neal, B and Tzoulaki, I},
doi = {10.1161/HYPERTENSIONAHA.119.14302},
journal = {Hypertension},
pages = {1--9},
title = {Estimated 24-hour urinary sodium excretion and incident cardiovascular disease and mortality among 398 628 individuals in UK biobank.},
url = {http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.14302},
volume = {76},
year = {2020}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We report on an analysis to explore the association between estimated 24-hour urinary sodium excretion (surrogate for sodium intake) and incident cardiovascular disease (CVD) and mortality. Data were obtained from 398 628 UK Biobank prospective cohort study participants (40-69 years) recruited between 2006 and 2010, with no history of CVD, renal disease, diabetes mellitus or cancer, and cardiovascular events and mortality recorded during follow-up. Hazard ratios between 24-hour sodium excretion were estimated from spot urinary sodium concentrations across incident CVD and its components and all-cause and cause-specific mortality. In restricted cubic splines analyses, there was little evidence for an association between estimated 24-hour sodium excretion and CVD, coronary heart disease, or stroke; hazard ratios for CVD (95% CIs) for the 15th and 85th percentiles (2.5 and 4.2 g/day, respectively) compared with the 50th percentile of estimated sodium excretion (3.2 g/day) were 1.05 (1.01-1.10) and 0.96 (0.92-1.00), respectively. An inverse association was observed with heart failure, but that was no longer apparent in sensitivity analysis. A J-shaped association was observed between estimated sodium excretion and mortality. Our findings do not support a J-shaped association of estimated sodium excretion with CVD, although such an association was apparent for all-cause and cause-specific mortality across a wide range of diseases. Reasons for these differences are unclear; methodological limitations, including the use of estimating equations based on spot urinary data, need to be considered in interpreting our findings.
AU  - Elliott,P
AU  - Muller,DC
AU  - Schneider-Luftman,D
AU  - Pazoki,R
AU  - Evangelou,E
AU  - Dehghan,A
AU  - Neal,B
AU  - Tzoulaki,I
DO  - 10.1161/HYPERTENSIONAHA.119.14302
EP  - 9
PY  - 2020///
SN  - 0194-911X
SP  - 1
TI  - Estimated 24-hour urinary sodium excretion and incident cardiovascular disease and mortality among 398 628 individuals in UK biobank.
T2  - Hypertension
UR  - http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.14302
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32623924
UR  - https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.14302
UR  - http://hdl.handle.net/10044/1/80774
VL  - 76
ER  -

Download

ProfessorAbbasDehghan

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)