Imperial College London
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ProfessorAbbasDehghan

Faculty of Medicine, School of Public Health

Professor in Molecular Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3347a.dehghan CV

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pazoki:2021:10.1038/s41467-021-22338-2,
author = {Pazoki, R and Elliott, J and Evangelou, E and Gill, D and Pinto, R and Zuber, V and Said, S and Dehghan, A and Tzoulaki, I and Jarvelin, MR and Thursz, M and Elliott, P},
doi = {10.1038/s41467-021-22338-2},
journal = {Nature Communications},
title = {Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes},
url = {http://dx.doi.org/10.1038/s41467-021-22338-2},
volume = {12},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Serum concentration of hepatic enzymes are linked to liver dysfunction, metabolic and cardiovascular diseases. We perform genetic analysis on serum levels of alanine transaminase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) using data on 437,438 UK Biobank participants. Replication in 315,572 individuals from European descent from the Million Veteran Program, Rotterdam Study and Lifeline study confirms 517 liver enzyme SNPs. Genetic risk score analysis using the identified SNPs is strongly associated with serum activity of liver enzymes in two independent European descent studies (The Airwave Health Monitoring study and the Northern Finland Birth Cohort 1966). Gene-set enrichment analysis using the identified SNPs highlights involvement in liver development and function, lipid metabolism, insulin resistance, and vascular formation. Mendelian randomization analysis shows association of liver enzyme variants with coronary heart disease and ischemic stroke. Genetic risk score for elevated serum activity of liver enzymes is associated with higher fat percentage of body, trunk, and liver and body mass index. Our study highlights the role of molecular pathways regulated by the liver in metabolic disorders and cardiovascular disease.
AU  - Pazoki,R
AU  - Elliott,J
AU  - Evangelou,E
AU  - Gill,D
AU  - Pinto,R
AU  - Zuber,V
AU  - Said,S
AU  - Dehghan,A
AU  - Tzoulaki,I
AU  - Jarvelin,MR
AU  - Thursz,M
AU  - Elliott,P
DO  - 10.1038/s41467-021-22338-2
PY  - 2021///
SN  - 2041-1723
TI  - Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-021-22338-2
UR  - http://hdl.handle.net/10044/1/87833
VL  - 12
ER  -
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