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@article{Tsilidis:2022,
author = {Tsilidis, K},
journal = {BMC Medicine},
title = {Circulating inflammatory cytokines and risk of five cancers: a mendelian randomization analysis},
url = {https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-021-02193-0},
volume = {20},
year = {2022}
}

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TY  - JOUR
AB  - Background: Epidemiological and experimental evidence has linked chronic inflammation to cancer etiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due to bias. In order to examine whether altered genetically-predicted concentration of circulating cytokines are associated with cancer development, we performed a two-sample Mendelian randomization (MR) analysis.Methods: Up to 31,112 individuals of European descent were included in genome-wide association study (GWAS) meta-analyses of 47 circulating cytokines. Single nucleotide polymorphisms (SNPs) robustly associated with the cytokines, located in or close to their coding gene (cis), were used as instrumental variables. Inverse-variance weighted MR was used as the primary analysis, and the MR assumptions were evaluated in sensitivity and colocalization analyses and a false discovery rate (FDR) correction for multiple comparisons was applied. Corresponding germline GWAS summary data for five cancer outcomes (breast, endometrial, lung, ovarian and prostate) and their subtypes were selected from the largest cancer-specific GWASs available (cases ranging from 12 906 for endometrial to 133 384 for breast cancer). Results: There was evidence of inverse associations of macrophage migration inhibitory factor with breast cancer (OR per SD = 0.88, 95%CI: 0.83 to 0.94), interleukin-1 receptor antagonist with endometrial cancer (0.86, 0.80 to 0.93), interleukin-18 with lung cancer (0.87, 0.81 to 0.93), and beta-chemokine-RANTES with ovarian cancer (0.70, 0.57 to 0.85); and positive associations of monokine induced by gamma interferon with endometrial cancer (3.73, 1.86 to 7.47) and cutaneous T-cell attracting chemokine with lung cancer (1.51, 1.22 to 1.87). These associations were similar in sensitivity analyses and supported in colocalization analyses. Conclusions: Our study adds to current knowledge on the role of specific inflammatory biomarker pathways in cancer etiology. Further va
AU  - Tsilidis,K
PY  - 2022///
SN  - 1741-7015
TI  - Circulating inflammatory cytokines and risk of five cancers: a mendelian randomization analysis
T2  - BMC Medicine
UR  - https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-021-02193-0
UR  - http://hdl.handle.net/10044/1/93142
VL  - 20
ER  -

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