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@article{Nazarzadeh:2023:cvr/cvac135,
author = {Nazarzadeh, M and Bidel, Z and Mohseni, H and Canoy, D and Pinho-Gomes, A-C and Hassaine, A and Dehghan, A and Tregouet, D-A and Smith, NL and Rahimi, K},
doi = {cvr/cvac135},
journal = {Cardiovascular Research},
pages = {835--842},
title = {Blood pressure and risk of venous thromboembolism: a cohort analysis of 5.5 million UK adults and Mendelian randomization studies},
url = {http://dx.doi.org/10.1093/cvr/cvac135},
volume = {119},
year = {2023}
}

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TY  - JOUR
AB  - AimsEvidence for the effect of elevated blood pressure (BP) on the risk of venous thromboembolism (VTE) has been conflicting. We sought to assess the association between systolic BP and the risk of VTE.Methods and resultsThree complementary studies comprising an observational cohort analysis, a one-sample and two-sample Mendelian randomization were conducted using data from 5 588 280 patients registered in the Clinical Practice Research Datalink (CPRD) dataset and 432 173 UK Biobank participants with valid genetic data. Summary statistics of International Network on Venous Thrombosis genome-wide association meta-analysis was used for two-sample Mendelian randomization. The primary outcome was the first occurrence of VTE event, identified from hospital discharge reports, death registers, and/or primary care records. In the CPRD cohort, 104 017(1.9%) patients had a first diagnosis of VTE during the 9.6-year follow-up. Each 20 mmHg increase in systolic BP was associated with a 7% lower risk of VTE [hazard ratio: 0.93, 95% confidence interval (CI): (0.92–0.94)]. Statistically significant interactions were found for sex and body mass index, but not for age and subtype of VTE (pulmonary embolism and deep venous thrombosis). Mendelian randomization studies provided strong evidence for the association between systolic BP and VTE, both in the one-sample [odds ratio (OR): 0.69, (95% CI: 0.57–0.83)] and two-sample analyses [OR: 0.80, 95% CI: (0.70–0.92)].ConclusionWe found an increased risk of VTE with lower BP, and this association was independently confirmed in two Mendelian randomization analyses. The benefits of BP reduction are likely to outweigh the harms in most patient groups, but in people with predisposing factors for VTE, further BP reduction should be made cautiously.
AU  - Nazarzadeh,M
AU  - Bidel,Z
AU  - Mohseni,H
AU  - Canoy,D
AU  - Pinho-Gomes,A-C
AU  - Hassaine,A
AU  - Dehghan,A
AU  - Tregouet,D-A
AU  - Smith,NL
AU  - Rahimi,K
DO  - cvr/cvac135
EP  - 842
PY  - 2023///
SN  - 0008-6363
SP  - 835
TI  - Blood pressure and risk of venous thromboembolism: a cohort analysis of 5.5 million UK adults and Mendelian randomization studies
T2  - Cardiovascular Research
UR  - http://dx.doi.org/10.1093/cvr/cvac135
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000848240600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://academic.oup.com/cardiovascres/article/119/3/835/6678130
UR  - http://hdl.handle.net/10044/1/108644
VL  - 119
ER  -

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