Imperial College London
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ProfessorAbbasDehghan

Faculty of Medicine, School of Public Health

Professor in Molecular Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3347a.dehghan CV

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dib:2022:10.3390/nu14235031,
author = {Dib, M-J and Ahmadi, KR and Zagkos, L and Gill, D and Morris, B and Elliott, P and Dehghan, A and Tzoulaki, I},
doi = {10.3390/nu14235031},
journal = {Nutrients},
title = {Associations of genetically predicted vitamin B12 status across the pohenome},
url = {http://dx.doi.org/10.3390/nu14235031},
volume = {14},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Variation in vitamin B12 levels has been associated with a range of diseases across the life-course, the causal nature of which remains elusive. We aimed to interrogate genetically predicted vitamin B12 status in relation to a plethora of clinical outcomes available in the UK Biobank. Genome-wide association study (GWAS) summary data obtained from a Danish and Icelandic cohort of 45,576 individuals were used to identify 8 genetic variants associated with vitamin B12 levels, serving as genetic instruments for vitamin B12 status in subsequent analyses. We conducted a Mendelian randomisation (MR)-phenome-wide association study (PheWAS) of vitamin B12 status with 945 distinct phenotypes in 439,738 individuals from the UK Biobank using these 8 genetic instruments to proxy alterations in vitamin B12 status. We used external GWAS summary statistics for replication of significant findings. Correction for multiple testing was taken into consideration using a 5% false discovery rate (FDR) threshold. MR analysis identified an association between higher genetically predicted vitamin B12 status and lower risk of vitamin B deficiency (including all B vitamin deficiencies), serving as a positive control outcome. We further identified associations between higher genetically predicted vitamin B12 status and a reduced risk of megaloblastic anaemia (OR = 0.35, 95% CI: 0.20–0.50) and pernicious anaemia (0.29, 0.19–0.45), which was supported in replication analyses. Our study highlights that higher genetically predicted vitamin B12 status is potentially protective of risk of vitamin B12 deficiency associated with pernicious anaemia diagnosis, and reduces risk of megaloblastic anaemia. The potential use of genetically predicted vitamin B12 status in disease diagnosis, progression and management remains to be investigated.
AU  - Dib,M-J
AU  - Ahmadi,KR
AU  - Zagkos,L
AU  - Gill,D
AU  - Morris,B
AU  - Elliott,P
AU  - Dehghan,A
AU  - Tzoulaki,I
DO  - 10.3390/nu14235031
PY  - 2022///
SN  - 2072-6643
TI  - Associations of genetically predicted vitamin B12 status across the pohenome
T2  - Nutrients
UR  - http://dx.doi.org/10.3390/nu14235031
UR  - http://hdl.handle.net/10044/1/101990
VL  - 14
ER  -
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