Publications
330 results found
Coombe DR, Davis C, Fincher G, et al., 2014, Letter to the Glycoforum Transforming Glycoscience: An Australian Perspective, GLYCOBIOLOGY, Vol: 24, Pages: 1-3, ISSN: 0959-6658
Sahadevan S, Antonopoulos A, Haslam SM, et al., 2014, Unique, Polyfucosylated Glycan-Receptor Interactions Are Essential for Regeneration of <i>Hydra magnipapillata</i>, ACS CHEMICAL BIOLOGY, Vol: 9, Pages: 147-155, ISSN: 1554-8929
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- Citations: 10
Nycholat CM, Peng W, McBride R, et al., 2013, Synthesis of Biologically Active <i>N</i>- and <i>O</i>-Linked Glycans with Multisialylated Poly-<i>N</i>-acetyllactosamine Extensions Using <i>P</i>. <i>damsela</i> α2-6 Sialyltransferase, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 135, Pages: 18280-18283, ISSN: 0002-7863
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- Citations: 44
Roberts B, Antonopoulos A, Haslam SM, et al., 2013, Novel expression of <i>Haemonchus contortus</i> vaccine candidate aminopeptidase H11 using the free-living nematode <i>Caenorhabditis elegans</i>, VETERINARY RESEARCH, Vol: 44, ISSN: 0928-4249
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- Citations: 37
Sassi A, Lazaroski S, Wu G, et al., 2013, Hypomorphic, Homozygous Mutations In Phosphoglucomutase-3 Impair Immunity And Increase Serum IgE Levels, UK-Primary-Immunodeficiency-Network (UK PIN) Meeting, Publisher: WILEY-BLACKWELL, Pages: 2-2, ISSN: 0009-9104
Boztug K, Jaervinen PM, Salzer E, et al., 2013, Deficiency Of JAGN 1 Causes Severe Congenital Neutropeni a Associated With Defective Secretory Pathway and Aberrant Myeloid Cell Homeostasis, 55th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971
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- Citations: 1
Malaspina A, Collins BS, Dell A, et al., 2013, Conference Report: "Functional Glycomics in HIV Type 1 Vaccine Design" Workshop Report, Bethesda, Maryland, April 30-May 1, 2012, AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol: 29, Pages: 1407-1417, ISSN: 0889-2229
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- Citations: 1
Nita-Lazar M, Ravindran C, Giomarelli B, et al., 2013, Zebrafish galectins bind to the infectious hematopoietic necrosis virus (IHNV) glycoprotein and modulate adhesion to the host cell surface, Annual Conference of the Society-for-Glycobiology, Publisher: OXFORD UNIV PRESS INC, Pages: 1343-1343, ISSN: 0959-6658
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- Citations: 1
Lo CY, Antonopoulos A, Dell A, et al., 2013, The use of surface immobilization of P-selectin glycoprotein ligand-1 on mesenchymal stem cells to facilitate selectin mediated cell tethering and rolling, BIOMATERIALS, Vol: 34, Pages: 8213-8222, ISSN: 0142-9612
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- Citations: 34
Choo MSF, Castangia R, Openshaw ME, et al., 2013, Identification and Characterisation of Lewis Antigens on Ovarian Cancer N-glycans using MALDI-QIT-TOF, Annual Conference of the Society-for-Glycobiology, Publisher: OXFORD UNIV PRESS INC, Pages: 1360-1360, ISSN: 0959-6658
Chan RWY, Karamanska R, Van Poucke S, et al., 2013, Infection of swine <i>ex vivo</i> tissues with avian viruses including H7N9 and correlation with glycomic analysis, INFLUENZA AND OTHER RESPIRATORY VIRUSES, Vol: 7, Pages: 1269-1282, ISSN: 1750-2640
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- Citations: 26
Haslam S, Panico M, Morris H, et al., 2013, Glycomics and glycoproteomics-providing new biological insights, Annual Conference of the Society-for-Glycobiology, Publisher: OXFORD UNIV PRESS INC, Pages: 1330-1330, ISSN: 0959-6658
Lo C, Antonopoulos A, Dell A, et al., 2013, Surface coupling of P-selectin glycoprotein ligand-1 onto mesenchymal stem cells enables leukocyte-like cell tethering and rolling, Annual Conference of the Society-for-Glycobiology, Publisher: OXFORD UNIV PRESS INC, Pages: 1411-1411, ISSN: 0959-6658
Ishihara M, Bubendorfer S, Dohlich K, et al., 2013, Analyzing the modification of the <i>Shewanella oneidensis</i> MR-1 flagellar filament, Annual Conference of the Society-for-Glycobiology, Publisher: OXFORD UNIV PRESS INC, Pages: 1352-1352, ISSN: 0959-6658
Bubendorfer S, Ishihara M, Dohlich K, et al., 2013, Analyzing the Modification of the <i>Shewanella oneidensis</i> MR-1 Flagellar Filament, PLOS ONE, Vol: 8, ISSN: 1932-6203
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- Citations: 11
Lo CY, Antonopoulos A, Gupta R, et al., 2013, Competition between Core-2 GlcNAc-transferase and ST6GalNAc-transferase Regulates the Synthesis of the Leukocyte Selectin Ligand on Human P-selectin Glycoprotein Ligand-1, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 288, Pages: 13974-13987
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- Citations: 34
Meyer BH, Peyfoon E, Dietrich C, et al., 2013, Agl16, a Thermophilic Glycosyltransferase Mediating the Last Step of <i>N</i>-Glycan Biosynthesis in the Thermoacidophilic Crenarchaeon <i>Sulfolobus acidocaldarius</i>, JOURNAL OF BACTERIOLOGY, Vol: 195, Pages: 2177-2186, ISSN: 0021-9193
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- Citations: 31
Bern M, Brito AE, Pang P, et al., 2013, Polylactosaminoglycan Glycomics: Enhancing the Detection of High-molecular-weight N-glycans in Matrix-assisted Laser Desorption Ionization Time-of-flight Profiles by Matched Filtering, Molecular & Cellular Proteomics, Vol: 12, Pages: 996-1004
For over 30 years, protocols based on the mass spectrometry (MS) of permethylated derivatives, complemented by enzymatic degradations, have underpinned glycomic experiments aimed at defining the structures of individual glycans present in the complex mixtures that are characteristic of biological samples. Both MS instrumentation and sample handling have improved markedly in recent years, enabling greater sensitivity and better signal-to-noise ratios, thereby facilitating the detection of glycans at much higher masses than could be achieved in the past. The latter is especially important for the characterization of the biologically important class of N-glycans that carry polylactosaminoglycan chains. Such advances in data acquisition heighten the need for informatics tools to assist in glycan structure assignment. Here, utilizing mouse lung tissue as a model system, we present evidence of polylactosaminoglycan-containing N-glycans with permethylated molecular weights exceeding 13 kDa. We show that antennae branching patterns and lengths can be successfully determined at these high masses via MS/MS experiments, even when MS ion counts are very low. We also describe the development and application of a matched filtering algorithm for assisting high-molecular-weight glycan detection and structure assignment.
Walther T, Karamanska R, Chan RWY, et al., 2013, Glycomic Analysis of Human Respiratory Tract Tissues and Correlation with Influenza Virus Infection, PLOS PATHOGENS, Vol: 9, ISSN: 1553-7374
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- Citations: 176
Bueno JC, Pang PC, Grassi P, et al., 2013, Early-onset severe preeclampsia-related changes in the glycosylation patterns at the maternal-fetal interface, 5th Latin American Symposium on Maternal Fetal Interaction and Placenta (SLIMP) / 4th Latin American Symposium on Reproductive Immunology (LASRI), Publisher: W B SAUNDERS CO LTD, Pages: A25-A25, ISSN: 0143-4004
Jimenez Del Val I, Constantinou A, Dell A, et al., 2013, An integrated mechanistic model for nucleotide sugar metabolism and monoclonal antibody glycosylation, Pages: 658-659
Almond RJ, Flanagan BF, Antonopoulos A, et al., 2013, Differential immunogenicity and allergenicity of native and recombinant human lactoferrins: Role of glycosylation, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 43, Pages: 170-181, ISSN: 0014-2980
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- Citations: 31
Neelamegham S, Lo C, Antonopoulos A, et al., 2012, Competition between core-2 GlcNAc transferase and ST6GalNAc transferase regulates the synthesis of the leukocyte selectin-ligand on P-selectin glycoprotein ligand-1, Joint Meeting of the Society-for-Glycobiology and American-Society-for-Matrix-Biology, Publisher: OXFORD UNIV PRESS INC, Pages: 1532-1533, ISSN: 0959-6658
Damerell D, Ceroni A, Maass K, et al., 2012, The GlycanBuilder and GlycoWorkbench glycoinformatics tools: updates and new developments, BIOLOGICAL CHEMISTRY, Vol: 393, Pages: 1357-1362, ISSN: 1431-6730
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- Citations: 117
Sternberg MJE, Tamaddoni-Nezhad A, Lesk VI, et al., 2012, Gene Function Hypotheses for the Campylobacter jejuni Glycome Generated by a Logic-Based Approach, Journal of Molecular Biology, Vol: 425, Pages: 186-197, ISSN: 1089-8638
Increasingly, experimental data on biological systems are obtained from several sources and computational approaches are required to integrate this information and derive models for the function of the system. Here, we demonstrate the power of a logic-based machine learning approach to propose hypotheses for gene function integrating information from two diverse experimental approaches. Specifically, we use inductive logic programming that automatically proposes hypotheses explaining the empirical data with respect to logically encoded background knowledge. We study the capsular polysaccharide biosynthetic pathway of the major human gastrointestinal pathogen Campylobacter jejuni. We consider several key steps in the formation of capsular polysaccharide consisting of 15 genes of which 8 have assigned function, and we explore the extent to which functions can be hypothesised for the remaining 7. Two sources of experimental data provide the information for learning—the results of knockout experiments on the genes involved in capsule formation and the absence/presence of capsule genes in a multitude of strains of different serotypes. The machine learning uses the pathway structure as background knowledge. We propose assignments of specific genes to five previously unassigned reaction steps. For four of these steps, there was an unambiguous optimal assignment of gene to reaction, and to the fifth, there were three candidate genes. Several of these assignments were consistent with additional experimental results. We therefore show that the logic-based methodology provides a robust strategy to integrate results from different experimental approaches and propose hypotheses for the behaviour of a biological system.
Canis K, McKinnon TAJ, Nowak A, et al., 2012, Mapping the N-glycome of human von Willebrand factor, BIOCHEMICAL JOURNAL, Vol: 447, Pages: 217-228, ISSN: 0264-6021
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- Citations: 76
Chen C, Constantinou A, Chester KA, et al., 2012, Glycoengineering Approach to Half-Life Extension of Recombinant Biotherapeutics, BIOCONJUGATE CHEMISTRY, Vol: 23, Pages: 1524-1533, ISSN: 1043-1802
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- Citations: 25
Rillahan CD, Antonopoulos A, Lefort CT, et al., 2012, Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome, NATURE CHEMICAL BIOLOGY, Vol: 8, Pages: 661-668, ISSN: 1552-4450
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- Citations: 291
Harrison R, Hitchen PG, Panico M, et al., 2012, Glycoproteomic characterization of recombinant mouse α-dystroglycan, GLYCOBIOLOGY, Vol: 22, Pages: 662-675, ISSN: 0959-6658
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- Citations: 46
Nacev BA, Grassi P, Dell A, et al., 2012, Itraconazole, an antifungal drug with anti-angiogenic activity, inhibits VEGFR2 trafficking, glycosylation, and signaling in endothelial cells, CANCER RESEARCH, Vol: 72, ISSN: 0008-5472
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