Imperial College London
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ProfessorAnneDell

Faculty of Natural Sciences, Department of Life Sciences

Professor of Carbohydrate Bichemistry
 
 
 
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Contact

 

a.dell

 
 
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Location

 

101BSir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wang:2021:10.1038/s41467-021-22365-z,
author = {Wang, Y and Khan, A and Antonopoulos, A and Bouche, L and Buckley, CD and Filer, A and Raza, K and Li, K-P and Tolusso, B and Gremese, E and Kurowska-Stolarska, M and Alivernini, S and Dell, A and Haslam, SM and Pineda, MA},
doi = {10.1038/s41467-021-22365-z},
journal = {Nature Communications},
title = {Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis},
url = {http://dx.doi.org/10.1038/s41467-021-22365-z},
volume = {12},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In healthy joints, synovial fibroblasts (SFs) provide the microenvironment required to mediate homeostasis, but these cells adopt a pathological function in rheumatoid arthritis (RA). Carbohydrates (glycans) on cell surfaces are fundamental regulators of the interactions between stromal and immune cells, but little is known about the role of the SF glycome in joint inflammation. Here we study stromal guided pathophysiology by mapping SFs glycosylation pathways. Combining transcriptomic and glycomic analysis, we show that transformation of fibroblasts into pro-inflammatory cells is associated with glycan remodeling, a process that involves TNF-dependent inhibition of the glycosyltransferase ST6Gal1 and α2-6 sialylation. SF sialylation correlates with distinct functional subsets in murine experimental arthritis and remission stages in human RA. We propose that pro-inflammatory cytokines remodel the SF-glycome, converting the synovium into an under-sialylated and highly pro-inflammatory microenvironment. These results highlight the importance of glycosylation in stromal immunology and joint inflammation.
AU  - Wang,Y
AU  - Khan,A
AU  - Antonopoulos,A
AU  - Bouche,L
AU  - Buckley,CD
AU  - Filer,A
AU  - Raza,K
AU  - Li,K-P
AU  - Tolusso,B
AU  - Gremese,E
AU  - Kurowska-Stolarska,M
AU  - Alivernini,S
AU  - Dell,A
AU  - Haslam,SM
AU  - Pineda,MA
DO  - 10.1038/s41467-021-22365-z
PY  - 2021///
SN  - 2041-1723
TI  - Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-021-22365-z
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000642510700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://doi.org/10.1038/s41467-021-22365-z
UR  - http://hdl.handle.net/10044/1/107486
VL  - 12
ER  -
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