Imperial College London
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ProfessorAnneDell

Faculty of Natural Sciences, Department of Life Sciences

Professor of Carbohydrate Bichemistry
 
 
 
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Contact

 

a.dell

 
 
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Location

 

101BSir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nita-Lazar:2015:10.1016/j.dci.2015.09.007,
author = {Nita-Lazar, M and Mancini, J and Feng, C and Gonzalez-Montalban, N and Ravindran, C and Jackson, S and de, las Heras-Sanchez A and Giomarelli, B and Ahmed, H and Haslam, SM and Wu, G and Dell, A and Ammayappan, A and Vakharia, VN and Vasta, GR},
doi = {10.1016/j.dci.2015.09.007},
journal = {Developmental and Comparative Immunology},
pages = {241--252},
title = {The zebrafish galectins Drgal1-L2 and Drgal3-L1 bind in vitro to the infectious hematopoietic necrosis virus (IHNV) glycoprotein and reduce viral adhesion to fish epithelial cells},
url = {http://dx.doi.org/10.1016/j.dci.2015.09.007},
volume = {55},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The infectious hematopoietic necrosis virus (IHNV; Rhabdoviridae, Novirhabdovirus) infects teleost fish, such as salmon and trout, and is responsible for significant losses in the aquaculture industry and in wild fish populations. Although IHNV enters the host through the skin at the base of the fins, the viral adhesion and entry mechanisms are not fully understood. In recent years, evidence has accumulated in support of the key roles played by protein-carbohydrate interactions between host lectins secreted to the extracellular space and virion envelope glycoproteins in modulating viral adhesion and infectivity. In this study, we assessed in vitro the potential role(s) of zebrafish (Danio rerio) proto type galectin-1 (Drgal1-L2) and a chimera galectin-3 (Drgal3-L1) in IHNV adhesion to epithelial cells. Our results suggest that the extracellular Drgal1-L2 and Drgal3-L1 interact directly and in a carbohydrate-dependent manner with the IHNV glycosylated envelope and glycans on the epithelial cell surface, significantly reducing viral adhesion.
AU  - Nita-Lazar,M
AU  - Mancini,J
AU  - Feng,C
AU  - Gonzalez-Montalban,N
AU  - Ravindran,C
AU  - Jackson,S
AU  - de,las Heras-Sanchez A
AU  - Giomarelli,B
AU  - Ahmed,H
AU  - Haslam,SM
AU  - Wu,G
AU  - Dell,A
AU  - Ammayappan,A
AU  - Vakharia,VN
AU  - Vasta,GR
DO  - 10.1016/j.dci.2015.09.007
EP  - 252
PY  - 2015///
SN  - 1879-0089
SP  - 241
TI  - The zebrafish galectins Drgal1-L2 and Drgal3-L1 bind in vitro to the infectious hematopoietic necrosis virus (IHNV) glycoprotein and reduce viral adhesion to fish epithelial cells
T2  - Developmental and Comparative Immunology
UR  - http://dx.doi.org/10.1016/j.dci.2015.09.007
UR  - http://hdl.handle.net/10044/1/30534
VL  - 55
ER  -
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