Imperial College London
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DrAliceDenton

Faculty of Medicine, Department of Immunology and Inflammation

Senior Lecturer
 
 
 
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Contact

 

a.denton

 
 
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Location

 

9N4bCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vanderleyden:2020:10.1016/j.celrep.2019.12.076,
author = {Vanderleyden, I and Fra-Bido, SC and Innocentin, S and Stebegg, M and Okkenhaug, H and Evans-Bailey, N and Pierson, W and Denton, AE and Linterman, MA},
doi = {10.1016/j.celrep.2019.12.076},
journal = {Cell Reports},
pages = {611--619.e4},
title = {Follicular regulatory T cells can access the germinal center independently of CXCR5},
url = {http://dx.doi.org/10.1016/j.celrep.2019.12.076},
volume = {30},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The germinal center (GC) response is critical for generating high-affinity humoral immunity and immunological memory, which forms the basis of successful immunization. Control of the GC response is thought to require follicular regulatory T (Tfr) cells, a subset of suppressive Foxp3+ regulatory T cells located within GCs. Relatively little is known about the exact role of Tfr cells within the GC and how they exert their suppressive function. A unique feature of Tfr cells is their reported CXCR5-dependent localization to the GC. Here, we show that the lack of CXCR5 on Foxp3+ regulatory T cells results in a reduced frequency, but not an absence, of GC-localized Tfr cells. This reduction in Tfr cells is not sufficient to alter the magnitude or output of the GC response. This demonstrates that additional, CXCR5-independent mechanisms facilitate Treg cell homing to the GC.
AU  - Vanderleyden,I
AU  - Fra-Bido,SC
AU  - Innocentin,S
AU  - Stebegg,M
AU  - Okkenhaug,H
AU  - Evans-Bailey,N
AU  - Pierson,W
AU  - Denton,AE
AU  - Linterman,MA
DO  - 10.1016/j.celrep.2019.12.076
EP  - 619
PY  - 2020///
SN  - 2211-1247
SP  - 611
TI  - Follicular regulatory T cells can access the germinal center independently of CXCR5
T2  - Cell Reports
UR  - http://dx.doi.org/10.1016/j.celrep.2019.12.076
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000508359200003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S2211124719317413?via%3Dihub
UR  - http://hdl.handle.net/10044/1/77128
VL  - 30
ER  -
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