Imperial College London
Portrait Picture

DrAliceDenton

Faculty of Medicine, Department of Immunology and Inflammation

Senior Lecturer
 
 
 
//

Contact

 

a.denton

 
 
//

Location

 

9N4bCommonwealth BuildingHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Denton:2019:10.1084/jem.20181705,
author = {Denton, AE and Carr, EJ and Magiera, LP and Watts, AJB and Fearon, DT},
doi = {10.1084/jem.20181705},
journal = {Journal of Experimental Medicine},
pages = {2242--2252},
title = {Embryonic FAP(+) lymphoid tissue organizer cells generate the reticular network of adult lymph nodes},
url = {http://dx.doi.org/10.1084/jem.20181705},
volume = {216},
year = {2019}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The induction of adaptive immunity is dependent on the structural organization of LNs, which is in turn governed by the stromal cells that underpin LN architecture. Using a novel fate-mapping mouse model, we trace the developmental origin of mesenchymal LN stromal cells (mLNSCs) to a previously undescribed embryonic fibroblast activation protein-α (FAP)+ progenitor. FAP+ cells of the LN anlagen express lymphotoxin β receptor (LTβR) and vascular cell adhesion molecule (VCAM), but not intercellular adhesion molecule (ICAM), suggesting they are early mesenchymal lymphoid tissue organizer (mLTo) cells. Clonal labeling shows that FAP+ progenitors locally differentiate into mLNSCs. This process is also coopted in nonlymphoid tissues in response to infection to facilitate the development of tertiary lymphoid structures, thereby mimicking the process of LN ontogeny in response to infection.
AU  - Denton,AE
AU  - Carr,EJ
AU  - Magiera,LP
AU  - Watts,AJB
AU  - Fearon,DT
DO  - 10.1084/jem.20181705
EP  - 2252
PY  - 2019///
SN  - 0022-1007
SP  - 2242
TI  - Embryonic FAP(+) lymphoid tissue organizer cells generate the reticular network of adult lymph nodes
T2  - Journal of Experimental Medicine
UR  - http://dx.doi.org/10.1084/jem.20181705
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000489118900005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://rupress.org/jem/article/216/10/2242/120534/Embryonic-FAP-lymphoid-tissue-organizer-cells
UR  - http://hdl.handle.net/10044/1/77122
VL  - 216
ER  -
Download