Imperial College London
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DrAliceDenton

Faculty of Medicine, Department of Immunology and Inflammation

Senior Lecturer
 
 
 
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Contact

 

a.denton

 
 
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Location

 

9N4bCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{van:2018:10.3389/fimmu.2018.02234,
author = {van, Nieuwenhuijze A and Burton, O and Lemaitre, P and Denton, AE and Cascalho, A and Goodchild, RE and Malengier-Devlies, B and Cauwe, B and Linterman, MA and Humblet-Baron, S and Liston, A},
doi = {10.3389/fimmu.2018.02234},
journal = {Frontiers in Immunology},
pages = {1--13},
title = {Mice deficient in nucleoporin nup210 develop peripheral T cell alterations},
url = {http://dx.doi.org/10.3389/fimmu.2018.02234},
volume = {9},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The nucleopore is an essential structure of the eukaryotic cell, regulating passage between the nucleus and cytoplasm. While individual functions of core nucleopore proteins have been identified, the role of other components, such as Nup210, are poorly defined. Here, through the use of an unbiased ENU mutagenesis screen for mutations effecting the peripheral T cell compartment, we identified a Nup210 mutation in a mouse strain with altered CD4/CD8 T cell ratios. Through the generation of Nup210 knockout mice we identified Nup210 as having a T cell-intrinsic function in the peripheral homeostasis of T cells. Remarkably, despite the deep evolutionary conservation of this key nucleopore complex member, no other major phenotypes developed, with viable and healthy knockout mice. These results identify Nup210 as an important nucleopore complex component for peripheral T cells, and raise further questions of why this nucleopore component shows deep evolutionary conservation despite seemingly redundant functions in most cell types.
AU  - van,Nieuwenhuijze A
AU  - Burton,O
AU  - Lemaitre,P
AU  - Denton,AE
AU  - Cascalho,A
AU  - Goodchild,RE
AU  - Malengier-Devlies,B
AU  - Cauwe,B
AU  - Linterman,MA
AU  - Humblet-Baron,S
AU  - Liston,A
DO  - 10.3389/fimmu.2018.02234
EP  - 13
PY  - 2018///
SN  - 1664-3224
SP  - 1
TI  - Mice deficient in nucleoporin nup210 develop peripheral T cell alterations
T2  - Frontiers in Immunology
UR  - http://dx.doi.org/10.3389/fimmu.2018.02234
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000445916100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.frontiersin.org/articles/10.3389/fimmu.2018.02234/full
UR  - http://hdl.handle.net/10044/1/77119
VL  - 9
ER  -
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