Imperial College London
Portrait Picture

DrAliceDenton

Faculty of Medicine, Department of Immunology and Inflammation

Senior Lecturer
 
 
 
//

Contact

 

a.denton

 
 
//

Location

 

9N4bCommonwealth BuildingHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Linterman:2014:10.7554/eLife.03180,
author = {Linterman, MA and Denton, AE and Divekar, DP and Zvetkova, I and Kane, L and Ferreira, C and Veldhoen, M and Clare, S and Dougan, G and Espeli, M and Smith, KGC},
doi = {10.7554/eLife.03180},
journal = {eLife},
pages = {1--31},
title = {CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection},
url = {http://dx.doi.org/10.7554/eLife.03180},
volume = {3},
year = {2014}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The co-stimulatory molecule CD28 is essential for activation of helper T cells. Despitethis critical role, it is not known whether CD28 has functions in maintaining T cell responsesfollowing activation. To determine the role for CD28 after T cell priming, we generated a strainof mice where CD28 is removed from CD4+ T cells after priming. We show that continued CD28expression is important for effector CD4+ T cells following infection; maintained CD28 is requiredfor the expansion of T helper type 1 cells, and for the differentiation and maintenance of T follicularhelper cells during viral infection. Persistent CD28 is also required for clearance of the bacteriumCitrobacter rodentium from the gastrointestinal tract. Together, this study demonstrates that CD28persistence is required for helper T cell polarization in response to infection, describing a novelfunction for CD28 that is distinct from its role in T cell priming.
AU  - Linterman,MA
AU  - Denton,AE
AU  - Divekar,DP
AU  - Zvetkova,I
AU  - Kane,L
AU  - Ferreira,C
AU  - Veldhoen,M
AU  - Clare,S
AU  - Dougan,G
AU  - Espeli,M
AU  - Smith,KGC
DO  - 10.7554/eLife.03180
EP  - 31
PY  - 2014///
SN  - 2050-084X
SP  - 1
TI  - CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.03180
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000344162200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://elifesciences.org/articles/03180
UR  - http://hdl.handle.net/10044/1/77125
VL  - 3
ER  -
Download